Rescue Medication help? Ideas? Anyone else develop medication tolerances?

I am not sure if this will help, as you mentioned you have tried most of the meds, but i will offer the advice anyways. I suffer from Chronic Daily Headaches and if i cant control the headache, within 3 days i have a Migraine.  I've tried Inderal, Topamax, Depakote and i am now on Keppra. And i also take 1000mg a day of Calcium/Magnesium and 200mg of Vitamin B2. I am not sure which medicine has been helping...as i started them all around the same time ..2 months ago.(the Keppra and vitamins)..but i am starting to see my headaches getting less frequent. I have also tried most of the Triptan meds...imitrex, relpax, axert, Treximet, and some others i cant even remember.Fiorecet worked for a while but it quit working.  The most recent my doc gave me is Maxalt and so far so good. I try and stay away from Tylenol completely because it does give me the rebound headaches. Since the maxalt and imitrex doesnt last all month, i will take a high dose of Ibprofen and sometimes goody powder works too (rarely, but if i take it at the beginning of a headache it will work) . My major problem is that 90% of the time my headache starts somewhere between 3 and 6am...so unless it wakes me up then, by the time i get up..i've had the headache for a couple hours and most of the meds didnt work very often. As long as a medicine works, i will take it. Once it stops, then we start all over again and look for a different med. Anyways, i would recommend trying the vitamin B2 and the Calcium citrate plus, with magnesium (its one pill) ....anythings worth a try. Hope you find some relief soon! ....oh and some of the triggers for me are, MSG, potato chips, bananas, some cereals, chocolate, too much caffeine, and of course rainy days and such!

Hi, I have a terrible problem with rebound headaches, I get them everytime I take a triptan especially zomig.  It ends up being a viscious cycle but usually I will have to go on prednisone for a while and this gets me out of rebound.  I try not to never take any other over the counters except for 2 Aleve w/a triptan (neuro recommended).  I recently went to a NP and he gave me a naturopathic remedy, he said it was a very diluted form of poison (sounds fun) but when your desperate you will try anything, I actually tried it this am as I felt my morning migraine coming on and it worked!!  We'll see it may have just been a coincidence.  Are your migraines hormonal at all?  A friend of mine uses progesterone cream and this works for her.  I have read a zillion migraine books and one that I liked is called Heal your headaches.  Another thing I do every day is a series of yoga postures for your head, and drink a full glass of water as soon as I wake up