I have been reading this board for awhile now, gathering information because my 21 year old daughter has suffered from migraine headaches since first grade(now in her third year of college). We've been to pediatricians, neurologists, general internists, massage therapists, orthodontists and now to a headache center. It seems that we never really get significant relief( she has a bad headache at least once a week). At her Dec. visit to the headhache center, however, the neurologist noticed a rapid heart rate and high blood pressure. We were immediately sent to the cardiologist who ran an EKG, bloodwork, and an echocardiogram along with his clinical exam. Although, her vital numbers were a little high, he seemed to brush it off. Her echo and bloodwork showed nothing. I was wondering if a PFO would have shown up on the echo? Did others with PFO's have symptoms? She is on Zanaflex, Cymbalta and Inderal (prescribed by the cardiologist). I actually think that I have noticed an improvement since she started the Inderal. I also am trying to get used to the fact that she is only 21 and on so much medicine although I don't want her having the headaches, either. I was wondering if the normal echo would rule out the possibility that a PFO could have been causing the headaches all of these years?