I'm new around here, so I don't know if this has been discussed or not, so I hope this is helpful. I suffered from debilitating migraines for more than 20 years, until I discovered that aspartame (as in the sweetener, Equal) was to blame. The funny thing is, I had already known that MSG caused my headaches, but it took me almost 20 years to realize that aspartame which is very similar to MSG, was also causing me so much misery. And it's hidden in so many things these days: chewing gum, toothpaste, almost anything labeled "diet." As soon as I stopped consuming this health-damaging ingredient, my headaches pretty much disappeared. (I still get the occasional menstrual migraine.) But the days of managing almost daily migraines with fiorinal were over as soon as I stopped consuming aspartame. BTW, I also don't trust any of the newer artificial sweeteners, like Splenda, either. Instead, I prefer to use natural sweeteners like stevia.