Topamax and Acid reflux

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New Member

Date Joined Oct 2010
Total Posts : 5
   Posted 12/24/2010 1:51 PM (GMT -6)   
I've been on topamax for over a month now. My migraines have really improved, but I have some questions. I cycled up on the meds. When I got to 100mgs, I started having some acid reflux that wasn't controlled by my prilosec which I have been on for years. I also had some other side effects as well. My doctor had me cycle back down to 75mg again and all the side effects went away. After two weeks he had me cycle back up to 100mg again, and the reflux came back. but not the other side effects.
Did anyone else have this problem? He really wants me on 100mg, but I can't imagine that the topamax would cause my prilosec not to work properly.  Anyone ever heard of this side effect?

Veteran Member

Date Joined Jun 2010
Total Posts : 2268
   Posted 12/25/2010 4:04 AM (GMT -6)   
Nope, not me at least but I drink at least 4 liters of water a day and I watch my food very well (even though I eat everything) due to my ulcerative colitis.

Now that you mention that you have acid reflux issue for a while, have you looked into the cause of it instead of just taking the meds?
Diagnosed March 2007 with left sided UC at the age of 30.
Currently on,
Colazal 9 daily,
Imuran, 100mg + 50mg
Vit. B12, 1mg
Multivitamin, 1 tablet daily
Fish oil 1200mg daily
Vit D 2000 IU daily.

Topamax 100mg + 100mg daily for migraine with aura. Migraine appears once a week, Ibuprofen 400mg is the only solution. Looking for alternatives.

Veteran Member

Date Joined Jun 2008
Total Posts : 903
   Posted 12/26/2010 12:37 PM (GMT -6)   
The cause of my reflux was an exceptionally weak lower esophageal sphincter; the cause was physiological not medicinal nor food related. Most people who have mild to moderate reflux can improve and perhaps "cure" reflux through diet, elevation of the bed, not wearing tight clothes and diet restrictions. Mine was severe enough that it caused lung damage, esophageal damage and I had to have a Nissen; I even get heartburn on water.

I was on Topomax; it worked wonders for the migraines, but I had respiratory issues with it and had to stop; it did not increase, nor decrease the reflux; but everyone is different and meds can affect people in different ways.. If the reflux is an issue; please see a gastroenterologist who may be able to help you. I can tell you that the I went through all 4 PPI's before finding one that worked; it may be an interaction that is causing the problem and maybe the answer is as simple as trying a different one.

good luck!

Veteran Member

Date Joined Dec 2008
Total Posts : 2386
   Posted 12/28/2010 6:10 AM (GMT -6)   
Takes a month to build up, and tastes wretched (hey I am warning you) but aloe vera juice works. You can get it through Market America (tastey there!) and if you drinks 2oz a day, your acid reflux a month later will improve majorily. I was on the purple pill, prilosec, protonix, zantac, 1 big bottle rolaids a week and tums when my friend dared me to quit my meds and just use rolaids, he swore by the aloe vera juice. Seriously, after a month on it, I noticed improvement. I ended up having a big bottle rolaids lasting a month and nothing else. So, I swear by aloe vera for acid reflux. Stopping 5 medications is great, healthier.
Don't Care Bout Nuffin No More, Guess I shouldnt even be in this world

Regular Member

Date Joined Jan 2011
Total Posts : 37
   Posted 1/4/2011 1:33 PM (GMT -6)   
Hi there :-)
I take 100mg topamax daily, and I did have this experience at first too...mainly at night when I was laying down. After a couple months it did go away, along with some of the other side effects.
I agree with the above poster on the aloe (although you can also get this in a health food store if that's more convenient for you). Also, if you avoid certain items in your diet it can help...i.e citrus (which is a migraine trigger anyhow), caffeine, alcohol, spicy foods, and high fat meals might help.
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