What are some medications that are known to cause rebound migraines and how long would they "typically" last? I know the duration would be different for everyone depending on the medication and how long they were using it for. My wife was taking (and possibly over using) Fioricet and Dilaudid the most. She also has tried Summatriptan and Naproxin (Equivelent to Imatrex), Flexeril, Comprazine, and Nubane. We are comming up to one year of nearly daily rebound migraines and not relief in sight. The last Dr. wants to send us to a headache clinic in Michigan somewhere. Anyone familiar with this place?