I'm sorry to hear that you've had a rough run over the past few years. It's certainly frustrating and enough to drive anyone mad. It's fantastic that you have such a positive attitude and continue to push forward.
After 4 years with no solution (yet) it's definitely time to get yourself into a good Headache Center/Clinic. Where are you located? I'm sure someone here will be able to give you a good recommendation, just as Janice has above.
Most of us have multiple headache types. A headache center will be able to better help you identify these. Then you can formulate a "plan of attack" better suited for you. They will also help you to rule out other causes of head pain, e.g. occipital neurolgia, idiopathic intracranial hypertension (IHH), medication overuse headache (aka rebound headaches), etc.
A thing to remember about
meds is 1) there are many (100++) that you can try, across many classes 2) even though one drug within a particular class did not work for you there may be others within the same class that will. If you look at the pharmacology of different anit-epileptic drugs (AEDs) for example, you will find that many are very, very different from one another. E.g. the mechanisms of action of Depakote are very different from Topamax, and the same holds true for Lyrica.
A new up and coming drug in the headache world that some people have tried is memantine. Who knows if it would be effective for you, but it is from a different class of drug than those you listed. This just illustrates how many meds there are out there that people haven't heard of or considered.
Have you tried breaking you're head pain with triptans. Sometimes breaking the cylce with injected steroids or toradol is helpful. You can also go to an impatient unit and they can give you i.v. medications.
Given your extensive trial of meds I assume you have tried these, but I'll throw them out there. Some find that supplements (in addition to meds or sometimes alone) can be helpful. The most common are: magnesium, feverfew, vitamin b2, butterbur (processed), CoQ10, and black cohosh (for women). There are others as well.
Keep pushing ahead and best of luck!
Post Edited (EvilFluorescents) : 1/30/2011 12:03:35 PM (GMT-7)