I had been on my 100mg dose of Topiramate (Topamax) for a month or so. It still hadn't cut the pain so I went back and the doc increased it. The strangest thing happened to me, which I quite liked. Before I had the strangest mood, I don't know if I could call it a depression. I just felt wrong. I work in a kitchen, and sometimes I felt like I wanted to throw knives at my coworkers head cause they made me so mad. I just felt like I just couldn't control my emotions sometimes. I talked to some of my other coworkers and they wanted to throw other stuff at those same coworkers so maybe it wasn't just the meds! When I went to the doctor, she increased the medication to 150mg per day. For 2 weeks I felt like I was really high on something. I was feeling really really good. It didn't last forever. But now my moods are stable, I have more good days than bad, and there is absolutely no depression any more. I am actually really happy with this side effect. I told my doctor about it, and asked to never be taken off of it. The side effects for the moods at the higher levels are so beneficial, it's unbelievable. At the lower dose, it was a nightmare.