Meds to break migraine

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Sassynrs
New Member


Date Joined Oct 2011
Total Posts : 3
   Posted 11/17/2011 10:30 AM (GMT -6)   
I have Chronic Refractory Migraines. Nothing works to relieve the horrific, debilitating pain that I experience on a near daily basis. Currently I am taking; Topamax (been on 400mg daily for 3 years), Valproic Acid, Fluoxetine, Trazadone, B2, Magnesium, CoQ10, and Aspirin daily. For abortive treatment: Promethazine, Imitrex injection, DHE injection, Toradol injection, Benedryl, and Xanax. I have been getting Botox injections for over a year,, and have tried Occipital Nerve Blocks.
I am admitted to the neuro unit about once a month where I stay for an average of 4-5 days to get infusions to help when I can't take it anymore and treat my severe dehydration. In the hospital I normally receive: DHE, Magnesium, Inepsine, Toradol, Reglan, Ativan, and a ton of fluids. More often than not, I leave (on my demand ) feeling only slight improvement, but I can't stand being away from my 3 incredible children any longer and I am frustrated at the lack of benefit I am getting, so I insist on going home. (The doctor allows my discharge only when he feels I am adequately hydrated.).
I have had this current migraine for approx. 38 days. On Monday my doctor put me on a tapering dose of Prednisone and daily Amerge, both of which I've tried with minimal success in the past. He said that if there's not improvement I would be admitted for IV therapy yet again. (Today is day #4 and there has been no improvement ).
I am truly at the end of my rope. I can't function due to the unremitting pain. I'm exhausted, frustrated, and feeling very hopeless. I need some relief even if it's just temporary. I'm looking for suggestions on what has been successful for others as far as IV therapy to break this never-ending migraine. I should mention I have also tried IV Thorazine, Valproic Acid, and a plethora of opioids. I'm wondering about Ketamine or possibly Lidocaine? If any of you have any ideas I would REALLY appreciate it.Thank you for your time and insight.
Chronic Refractory Migraine
ADHD, Anxiety/depression
Botox,Adderall,Topamax, Asa, Co-Q, Mg+,B2,Trazadone
DHE IM, Toradol IM, Promethazine, Xanax, Imitrex inj
Diet, Exercise, CognitiveBehavioralTherapy, Relaxation, Sleep sched.
"Perhaps strength doesn't reside in never have being broken...
...perhaps it's in growing strong in the broken places."

deltaforce
Veteran Member


Date Joined Jun 2010
Total Posts : 2268
   Posted 11/17/2011 5:59 PM (GMT -6)   
I feel your terrible pain. Though my condition is not as worse as yours, when I do get migraine attack, my response is, I would prefer death. You are just a walking pharmacy like me, but I do not recognize all the drugs that you are taking. I realize that you are taking Topamax for migraine, what else is prescribed to you for migraine? My feeling is, you should stop topamax, its not working anyways. Are you really taking all 5 or 6 drugs as an abortive? Have you tried as simple as Ibuprofen 400mg or Neproxen 250mg? Using these for long term is NOT recommended.

Read my post in this thread http://www.healingwell.com/community/default.aspx?f=31&m=2262432

From your post, it sounds to me that your doc is handling your treatment in more of a haphazard manner. If he is not keeping good notes, may be you should maintain a headache diary on what you are taking and if its helping or not. If something is not helping, why take another dose of that drug. If you are not seeing a neurologist, consult one. If this doc is a neurologist, may be its time to change. Read up about this condition on reputed websites like Mayo Clinic or WebMD about the possible drug options. You get Imitrex injections but there are options of trying other triptan derivatives as well. There are beta-blockers (e.g. Inderal) or calcium channel blockers (e.g. Verapamil) could be used. I don't see that used yet. Seriously, there are loads of options still available, don't give up hope. You need to find a good doc. I wonder when you are admitted to the hospital, why they never did a proper thorough checkup? Fill me in if I am missing something.
The key in everything is your diary. I can't tell the importance of these notes as much. My current neurologist actually thanked me for maintaining a perfect diary. It helped him a lot to figure out what else has worked or not in the past and how he should proceed and I maintain such diary even now. Additionally, I use patientslikeme.com to keep track of all the medications. The diary becomes overwhelming at a time, since I am a walking pharmacy.
Diagnosed March 2007 with left sided UC at the age of 30.
Currently on,
Colazal 9 daily, Imuran, 100mg + 50mg, Vit. B12, 1mg, Multivitamin, 1 tablet daily, Fish oil 1200mg daily, Vit D 2000 IU daily, Butterbur 150mg daily.

Verapamil 240mg for migraine, Migraine episode now at least twice a month,
Ibuprofen 400mg is the only solution (but leads to bleeding). Looking for alternatives.

Sassynrs
New Member


Date Joined Oct 2011
Total Posts : 3
   Posted 11/18/2011 12:24 AM (GMT -6)   
Deltaforce, thank you so much for taking the time to read my post, and for your response. I am new to this and wasnt sure what to expect or how many details to give.
Okay, where to start... Ive suffered from migraines since I was 10, (I am 36 now). Over the years they have increased in frequency, duration and severity. I have seen 5 neurologists and 4 headache specialists.I have had several MRI, MRA's, CT scans, and 2 Lumbar Punctures. I have frequent labwork done to monitor my dehydration, kidney/liver function etc.etc. My last draw was actually today.
Ihave tried the following meds to name just a few: Gabapentin, Zonegran, Propanolol, Atenolol, Verapamil, Amitriptyline, Tramodal, Percocet, Vicodin, Reglan, Zofran, Compazine, Prochloraperazine, and Namenda just off the top of my head). For abortives: I've used every Triptan on the market in various forms. I've been using Imitrex oral and sub-q injections for about 3 years and its effectiveness continues to dwindle with time. Due to the fact that I experience severe vomiting with my migraines I can no longer take oral forms of the meds. I use injections and suppositories. DHE has been added to my arsenol just 6 months ago... As I said earlier, its hit or miss.
All of the medications I listed in my prior post are taken for migraine, including the supplements-Magnesium, Riboflavin, and CoQ10. I have recently discontinued taking Buttetbur and Melatonin as they did not have any effect.
I have completed Cognitive Behavioral Therapy (althoufh I still see my counselor on occasion), Chronic Pain group counseling, and Depression group therapy. I have done accupuncture, massages, and seen Occupational therapists as well as a dietician. I exercise daily (severe pain allowing), I do yoga as well as aerobics and weight lifting.
I am meticulous with my headache journal and have been for the last 5 years. I know my triggers inside and out and avoid them at all costs, although it doesn't make a huge difference. It gives me a sense if control and organization anyhow.
I am on a strict diet, and do not drink alcohol or caffeine. I should add that I'm a freak when it comes ro routine... No skipped meals, and I have a sleep schedule that I do my best to adhere to. When the pain is really bad that interferes with my ability to sleep so I use Xanax sparingly.
I am a nurse, although I haven't worked in two years due to my head... So I know the importance of utilizing coping skills, and how imperative it is to be your own advocate. I have been researching Chronic Refractory Migraines, the physiology, treatments and any and all other information I can get my hands on.
My current doctor is a migraine specialist. I've only been seein.g him since September of this year but thus far I do like him. He is very proactive, ambitious and educated on all of the latest information on migraines. He is actually reducing my Topamax and Fluoxetine.
He has mentioned sending me to one of "the big headache hospitals", but insurance is definately a factor. He hasn't mentioned what iv therapy hes willing to try with me in the future, I don't know what hes all prepared to do.
Honestly, I am one of the extreme cases. I have been told by numerous doctors that my situation is rare. I've been told (and as far as I know), I am doing everything right... I am at my wits end. I have a VEEY steong fairh in God and three of the most amazing children to have ever been born. If it weren't for those things I don't know what I would do or where I would be right now.
So, now that I have told you my life story... I M sorry it was so lengthy. Please let me know if you have any further thoughts. I REALLY appreciate anything that you or anyone has to offer. I will pray for pain-free days for you.
Thank you again and God bless,
Sassynrs
Chronic Refractory Migraine
ADHD, Anxiety/depression
Botox,Adderall,Topamax, Asa, Co-Q, Mg+,B2,Trazadone
DHE IM, Toradol IM, Promethazine, Xanax, Imitrex inj
Diet, Exercise, CognitiveBehavioralTherapy, Relaxation, Sleep sched.
"Perhaps strength doesn't reside in never have being broken...
...perhaps it's in growing strong in the broken places."

deltaforce
Veteran Member


Date Joined Jun 2010
Total Posts : 2268
   Posted 11/18/2011 10:34 AM (GMT -6)   
Wow, you are going through a lot. I thought my migraine is worse but your story sounds really bad. I honestly don't have any new to offer, still curious if you have tried NSAIDs. I am not giving high hopes but incase if you have not tried, what if you take an anti-emetic at an onset of migraine and then take oral medication like Advil or Alleve. Sometimes we do ignore drugs in our cabinet and run to the pharmacy. Actually, you are a nurse by profession so you are certainly well informed about medications than I am.

When I could not find resort, I was seriously considering going to a specialist listed on mychronicmigraines.com They do have a commercial on TV sometimes. It is sponsored by Allergen, so I presume they have some new drug.

Finally, I think there is a major flaw in our medical system where treatment is offered according to the symptoms, no one aims to treat the cause. I suspect that my migraine is as a result of inflammation but don't have strong evidence to support my argument. I asked my neuro to look into it and he didn't quite take it. He took it as an hypothesis and wasn't much willing to look into it any further, may be he doesn't know either.

My best wishes that you find something to get this crap under control. Now as and when I am going to have a migraine attack, will definitely think of you that there is someone out there who has been going through worse than me. If possible, I would like to follow up on your story. So if there is anything new comes up, please take an effort to post it here.

Good Luck.
Diagnosed March 2007 with left sided UC at the age of 30.
Currently on,
Colazal 9 daily, Imuran, 100mg + 50mg, Vit. B12, 1mg, Multivitamin, 1 tablet daily, Fish oil 1200mg daily, Vit D 2000 IU daily, Butterbur 150mg daily.

Verapamil 240mg for migraine, Migraine episode now at least twice a month,
Ibuprofen 400mg is the only solution (but leads to bleeding). Looking for alternatives.

JacquelineXx
New Member


Date Joined Nov 2011
Total Posts : 3
   Posted 11/23/2011 12:44 AM (GMT -6)   
Oh my gosh, Sassy. You have a handful there, don't you? That's probably an EXTREME understatement but my God I could not pass up your story even though what I offer you might not do anything. I get migraines too, so much so that I have been diagnosed with debilitating depression along with my whole high school experience being stripped from me, so I get where you are coming from even if it's only a little bit. Something you might want to check into is them being hormonal migraines. Mine usually occur when I'm ovulating, on the day I get my period, and on the day it ends. Have you noticed any type of pattern like that? There is also this psychic (not don't lose me here) who was so incredible at predicting things from a type of sleeping state that he was called the sleeping prophet, and his name was Edgar Cayce. I got so desperate one night and looked up if anyone had ever gone to him with migraines, asking to know what caused theirs, and every time someone asked him, he said that it had something to do with their colon. Now I'm not sure if you're up for a colonoscopy, but I feel like you would try anything right now. Who knows? You could have some kind of inflammation or infection you didn't know about that is causing you this severe pain. Ugh I'm sorry I didn't offer much to you but I couldn't pass your story up with at least trying to help. I also think you should really try to avoid taking aspirin when you can because you can get rebound headaches that will throw you into a treacherous migraine cycle that you can be stuck in for weeks until a medicine like DHE breaks that cycle. I don't know if you already knew that but I'm just throwing it out there.

Good luck, I sincerely hope you start feeling better and find the help you need. Stay strong. You have an entire support system here on healingwell. <3

Lauramuppet
New Member


Date Joined Jun 2014
Total Posts : 2
   Posted 6/10/2014 6:58 PM (GMT -6)   
This post was from awhile ago. I wondered how you were doing? Have you read Heal Your Migraine, the 1,2, 3 approach? it's helped me get out of a rebound situation before. However I have backslid on my trigger free diet and began taking way too many triptans per week. So I'm back in rebound. Now I have a question for you? I'm stuck in a headache cycle of every days or every other day. I'm going to take the books advice and stop using triptans or narcotics, until my system has recovered. However, is there a drug that can stop my current headache state that is not a triptan or narcotic? I need some relief. Thanks for your help.

BnotAfraid
Forum Moderator


Date Joined Apr 2012
Total Posts : 7515
   Posted 6/12/2014 1:36 PM (GMT -6)   
Sass,

Your story is so very close to mine. After 7 neurologists I ended up at John Hopkins in MD. (see Diag. after signature.) TN, cluster headaches and HC were all diag. prior to my suppressed memories coming out.

This is the cocktail I have been on for 3 years now, I still get daily pain, 3-4 on the pain scale; thunderstorms will rack it up to a 9. When i take Imitex nasal[ bitter I know]. I also have Tylenol 3 for TN/cluster combo pain.

Cymbalta 60mg am Pain
Synthroid 50mg am (thyroid was dbl what it should be, can cause
head pain it has made a diff)
Topamax 225mg per day [100 am 125 pm]
Propranolol 40mg 2x day [down from 3 since synthroid began]
Magnesium 1000mg nerve health
Zinc 500 mg stops ear buzzing, ringing, squeals, etc...

T3 for BAD break through pain
Imitrex to fully function

Just info, see what your doc thinks, I weigh 160 lbs so I supposes does would be adjusted accordingly. If you have not, just your thyroid, simple blood test.

I hope you find a platuea soon.
Peace and strength
Moderator - Depression
Be still and know there is Peace.

Kabir says: "Student tell me, what is God? He is the breath inside the breath". from the poem Breath.
DX: reverse Trigeminal Neuralgia;Cluster headaches; Atypical face pain;Hemicrania Continua; raynauds;complex PTSD; recurring MDD,disassociative disorder;
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