Migraine meds dosage

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New Member

Date Joined Oct 2012
Total Posts : 1
   Posted 10/13/2012 1:01 AM (GMT -6)   
I wanted to take a moment to let you know about my latest migraine progress. Over the last 7-8 months the migraines have increased in frequency, duration, and intensity. They have knocked me out of my regular life- it's been depressing.
It's been a real mystery because back in 2010, I began taking toporamate and noticed an immediate reduction in migraines. I got a migraine only every 3-4 months and they were easily taken care of with a simple injection of Imitrex.
When the migraines began occurring about once a week, I started thinking that I should see my migraine specialist.
What I learned from her was shocking!
Turns out I was suffering from a lower dose of my topiramate due to the fact that the FDA allows manufacturers of generic drugs to make them with up to 20% less than the name brand drug! My pharmacy switches between whichever is the cheaper manufacturer. So, I thought that I was taking 100 mg of topiramate and was actually getting only getting 80! Thus the increasing migraines. Thankfully, my doctor was a pharmacist in a former life and knew all about this. I asked her if all doctors are told about this FDA ruling. She laughed.
Knowledge is power. If you are taking generic drugs that are dependent upon dosage, check with your doctor. You can ask your pharmacist to always order your medication from the same manufacturer.

Veteran Member

Date Joined Jun 2010
Total Posts : 2268
   Posted 10/23/2012 2:32 PM (GMT -6)   
Not too sure where did you learn that 80% part but it is NOT true. Generic medication is supposed to release exactly the same amount of drug as its branded counter-part. Only issue that is more important when it comes to the generic drugs, bioavailability of the drug (your 80% thing) and the time it takes to reach stated bioavailability. Both of these factors are supposed to match the branded version of the drug within the error margins, otherwise such generic is NOT approved by the FDA.

If your doc just agreed to what you stated here, she just doesn't want to spend time with you to explain these factors. If she thinks that this is true, ask her for proof. I would very much like to see it.
Diagnosed March 2007 with left sided UC at the age of 30.
Currently on,
Colazal 9 daily, Imuran, 200mg daily, Vit. B12, 1mg, Multivitamin, 1 tablet daily, Fish oil 2400mg daily, Vit D 2000 IU daily.

Verapamil 240mg for migraine, Migraine episode now at least twice a month,
Ibuprofen 400mg is the only solution (but leads to bleeding). Looking for alternatives.
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