Here is a thread from the ulcerative colitis forum saying how histamines aggravated his IBD symptoms. But as you can see histamines can also aggravate migraines:www.healingwell.com/community/default.aspx?f=38&m=3153074www.medscape.com/viewarticle/811920 VIENNA, Austria — Preventive treatment with diamine oxidase (DAO), an enzyme that degrades histamine, significantly shortened the duration of migraine attacks and trended toward reducing the number of episodes.
Histamine is present in many foods, is released in allergic reactions, and is one of the chemical mediators that contributes to migraine. about 25% of the population may have an alteration in DAO that decreases its activity in breaking down histamine. The enzyme is expressed most in the intestine, kidney, and placenta.
"We diagnosed 137 patients who have a migraine, of whom 119 showed deficits of the activity of the enzyme, around 87% of the total patients that we have studied," said Joan Izquierdo, MD, from the Faculty of Health Sciences at the International University of Catalonia and the neurology service at Catalonia General Hospital in Barcelona, Spain.
He said normal enzyme activity is a score of at least 80 histamine-degrading units [HDU]/mL.
In a survey administered in 2006 and again in 2012, symptom scores correlated with enzyme activity. Symptom scores rose progressively as enzyme activity dropped below 80 HDU/mL, with scores 50% to 120% higher in the 30-40 HDU/mL range compared with enzyme activity >80 HDU/mL.
Speaking here at the XXI World Congress of Neurology (WCN), Dr. Izquierdo presented the results of his single-center, double-blind, placebo-controlled trial of DAO oral supplementation, called MIGRADAO 002, as a preventive treatment in patients with DAO activity less than 80 HDU/mL and episodic migraine with or without aura, diagnosed according to the criteria of the International Headache Society.
Participants were men or women age 18 to 60 years old with an attack within the previous 6 months. Most of the patients were women, with only 8 men in each group. The placebo and medication groups were well matched for median age (approximately 40 years) and age range (18 to 65 years).