Does your body acclimate to amitryptiline?

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Sick Puppy
Regular Member


Date Joined Feb 2015
Total Posts : 33
   Posted 12/17/2017 10:25 PM (GMT -7)   
Those who have tried amitryptiline, did you acclimate to it and have to raise the dosage? Was there a dosage at which it worked for a long time? What's the highest dosage you tried before deciding it wasn't working?

I've had migraines since I was 17, but for most of my life they were a couple a month and excedrine generally took care of them. In the past few years they've gotten more frequent. I was on amitryptiline for about a year, at 25mg. It didn't seem to affect the migraines much (did help my insomnia though, for a while.) I stopped taking it for about six months, and was recently put back in it, at a dosage of 50mg. It worked immediately - I had had several days of migraines and the first day after starting the new dosage I could feel that the migraine was...sort of blocked is the best way I can describe it. That was about 3 months ago and now it doesn't seem to be working. I've had several migraine days this week and at least one each week for the past several weeks.

So I'm wondering, is my body acclimating to the medication? I could raise the dosage, but wouldn't I just acclimate again and have to raise it again, and so on? What's the upper limit on amitryptiline? My doctor offered me to try topamax but I'm concerned about side affects. I haven't seen a headache specialist yet (though I think it might be time to) so it's just my regular primary care doctor at the moment.

straydog
Forum Moderator


Date Joined Feb 2003
Total Posts : 15525
   Posted 12/19/2017 3:49 PM (GMT -7)   
Hello Sick Puppy & welcome to Healing Well. I don't think there is really a magic number with Amitriptiline, its more of how the person responds to it. You may want to consider another increase, however, if the relief is short term, perhaps consider a new medication. Are you seeing a neurologist?

Take care.
Susie
Moderator in Chronic Pain & Psoriasis Forums

BnotAfraid
Forum Moderator


Date Joined Apr 2012
Total Posts : 7233
   Posted 12/21/2017 12:06 PM (GMT -7)   
Sick Puppy

I just started on this med as a secondary to topomax. I started at .5mg 3 days a week the 10mg 3days week now I am at 10mg every day.

However I know people at 100mg a day.

Like all meds, it is always an individual case weather or not the meds need to increase. Weather is a big trigger. Perhaps you need to look at a rescue/abortive med to had

Peace
Trina
Moderator - Depression

"...when the gift of sight is cause enough for jubilation."
Billy Collins from the poem. HIGH

DX: reverse Trigeminal Neuralgia;Cluster headaches; Atypical face pain;Hemicrania Continua; raynauds;complex PTSD; recurring MDD,disassociative disorder;

BnotAfraid
Forum Moderator


Date Joined Apr 2012
Total Posts : 7233
   Posted 12/29/2017 3:36 PM (GMT -7)   
SP

I hope you are feeling better.

Along with 250mg topomax a day, I am now up to 10mg a day [taken at night] of the amitryptiline.

I see an improvement in my pain level and have requested an increase in the med. Now I am extremely sensitive to medications, so a person who would be taking 100mgs, I might take 25mg or 50mg.

Talk to your doc about combo meds and all your side effects.

Peace
Trina
Moderator - Depression

"...when the gift of sight is cause enough for jubilation."
Billy Collins from the poem. HIGH

DX: reverse Trigeminal Neuralgia;Cluster headaches; Atypical face pain;Hemicrania Continua; raynauds;complex PTSD; recurring MDD,disassociative disorder;
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