I'm just new to the site, but your posting immediately caught my attention. I have real problems with fatigue as a result of my migraines and the medication as well. I used to take Topamax, and it really made me tired. I took it for a few months and although it helped at first, it stopped working for me after awhile so I stopped taking it. The side effects are really lousy, hey? I am taking Inderal now, and the side effects aren't so bad, although they do make me tired as well. I can sure understand how you would be so tired all the time taking both of these medications at once.