My doctor has actually prescribed DHE injections for me to do at home. I take Zofran about
30 minutes prior to a DHE injection as they can make you nauseated. I have to say I have literally been on everything ( I have a two page list I keep with my medical records!) and Topamax as a preventative and DHE with migraines level 6-10, has been the best "cocktail" for me.
Good luck with the DHE, like everything else it affects everyone differently