Kiera asked about pain in another thread. Rather than letting this get lost in the thread, I'm making a new post.
I'm quoting below from the book, "Multiple Sclerosis: The Questions You Have, The Answers You Need", edited by Rosalind C. Kalb, Ph.D.
I have the second edition; I think a third edition is available now. It's also in many libraries, as the publisher donated thousands of copies to libraries in the US. The book is set up as if someone asked the question, and then it's answered:
"What types of pain can be caused by MS? What are the best treatments for the different bypes of pain?"
Pain in MS can take different forms. The most common is called dysesthesia, referring to a burning sensation caused by abnormalities in the sensory pathways in the brain and spinal cord. Demyelination in the sensory pathways can result in pain, numbness, tingling, itching, or other abnormal sensations. Sometimes the pain is quite severe or sharp, most commonly in the trigeminal nerve of the face. Trigeminal neuraligia is often described as a stabbing or shock-like pain along the side of the face. These types of pain do not respond to ordinary pain medications. The preferred treatment is to try to alter the faulty nerve conduction with other types of medications, including antiepileptic drugs such as Neurontin, Tegretol, Dilantin, and Depakene. Antidepressant medications such as Elavil may also relieve the pain. Some people find that acupuncture and meditation oare effective for dysesthesias.
A second, relatively common type of pain or discomfort in MS results from the symptoms of spasticity -- increased muscle tone and muscle spasms can be quite uncomfortable. Antispasticity medications are the most effective treatment for this type of discomfort.
In addition to these more common types of pain in MS, secondary orthopedic pain can result from changes in a person's posture or gait. If a person begins to walk or stand differently because of weakness or spasticity, for example, these changes can in turn cause pain in the knees, back, or hips. It is important to identify the causes of this type of secondary pain so that an appropriate treatment regimen of physical therapy, gait training, seating assessment (for someone in a wheelchair), exercise, and pain relief can be implemented."
...I am not a doctor, nor health professional, and don't pretend to be one, here.....