I’m so sorry you’re having such a hard time with the avonex. Those injections sound pretty miserable. I was on Copaxone for around 9 months at one point (before being redxed with CIS). Due to my current dx, I can’t speak to how Copaxone affected disease activity, so I’ll just write my experience with the shots, themselves.
I have to be honest and say that it took me awhile to get used to the daily injections. However, the shots eventually just became part of my nightly routine, and stopped being a big deal. I used the autoject for all of my injections, since I could just load it and press a button and the shot was done. I liked the fact that I never had to see the needle, or jab it in to my skin.
I did have large injection site reactions in the beginning (swelling, pain, itching etc) but they got less extreme over time. Like Gretchen, I also rarely found the shots themselves to be painful. The delayed stinging was intense at times, but didn’t last too long…it also didn’t seem to bother me as much after a few months on the med. I did end up with some good lumps at old injection sites that took awhile to soften up. I would not hesitate to go back on Copaxone in the future. I hope some people with experience with Rebif and Betaseron will respond to your post, so you can get a better idea about what these meds are like as well.