Hi Paul, and welcome!
I’m so sorry to hear about your dx and the rough time you’ve been having. I hope this board can provide you with some support and information. Unfortunately none of us can tell you which med is the “right” one for you at this time, as this is something that you need to decide with your neuro. However, we do have members on here who have experience with pretty much all the meds, including Tysabri. I’m sure people will be happy to share their experiences with you.
I’ll start, although I’m not sure how helpful my experience will be: I was on Copaxone for around 9 months, and tolerated the injections pretty well. Copaxone is a daily injection, and can be irritating to the skin. When I first started this med, every shot was a big deal, but after a few months it became a part of my routine. I had the common skin issues at the injection sites, but no other side effects while I was on it. I can’t speak about how it affected progression as it takes about that long to start “working,” and my situation is a bit complicated at this point. However, there are other members on here who are doing quite well on this med. Copaxone is not an interferon, so it doesn’t have the flu-like side effects that are common with the interferons (Avonex, Betaseron, Rebif). There is a chance that you can have an Immediate Post Injection Reaction, which can be very uncomfortable but is harmless.
The board is pretty slow right now, but I’m guessing others will be along to share their experiences too. There are past posts from the Tysabri users on this board if you want to read them, and hopefully one of them will see your post as well since this seems to be the direction your neuro would like you to go.
Best of luck to you, I know this is a big decision.