I take copaxone, not rebif. But I tried cymbalta right after my MS diagnosis (1 yr ago), and it made me so sick. I couldn't quit vomiting while taking the Cymbalta, I only made it 5 days and quit taking it. My neuro kept saying if I would give it a week or so the vomiting would stop, but I'm stubborn I guess. She was giving it to me for nerve pain (she said) but I believe she suspected depression too. Who knows, but now I just take xanax (like Jules) and it helps allot. No anti-depressant.