I was diagnosed with MS in May of 2003. I have been on LDN (Low Dose Naltrexone) as treatment since 2004. It helped me to stop my progression and got me to where I am today. I was on the verge of having to quit my job when I started on it. It is supposed to work by tricking the body into making extra endorphins. It appears to do that but in the process it causes your body to also make more cortisol. The reason I'm telling you this is that I found out in 2004 that I had low adrenal function. I know that the LDN did not cause the adrenal disease but it gave me a clue to help me find out that it was adrenal disease that was causing my MS symptoms. The reason it had been missed is that doctors almost always test for cortisol levels only in the morning. Mine was always normal in the morning but droppped sharply by noon and stayed that way all day. If you have been diagnosed with MS or suspect you may have MS and you have fatigue, please get the all day saliva test to rule out adrenal disease. Once you get diagnosed with MS it is difficult if not impossible to get that diagnosis reversed. Adrenal disease is treatable and although it can be serious for some, it is easily managed compared to MS.