If I remember correctly, you are on avonex? I'm so glad its getting easier for you! I've been on it for about 4 months now. usually its doesnt hurt when i give myself the shot, but I still get nervous right when I'm giving it. The side effects are manageable with ibprofen, I try to take it around the clock for the 24 hours. Some weeks are better then others, I took my shot last night and today i have a headache and body aches, but its not too bad. I did find that doing the shot before bedtime is better for me, that way i sleep through the worst of it. You might want to try that and the ibprophen if you haven't already.