Avonex prefilled vs. powder

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Veteran Member

Date Joined Dec 2005
Total Posts : 896
   Posted 2/9/2007 6:32 PM (GMT -6)   
Can anyone tell me if they have had less side effects on the powder "mix your own" Avonex VS. the prefilled?
I continue to have such a battle with side effects.  Last night I had severe chills for 3 hours then ran 103 fever.  I have every side effect listed except for diarrea ( and that would be a welcome one!) 
I called the neuro and her nurse said some folks have less side effects on the powder mix.  Avonex does not acknoledge that, they say the formulas are the same and there is no basis for it but some folks do have less side effects with one form or the other.
I am feeling quite ill these days, not only with the MS but I'm still trying to recover from sugery and had to have a large hematoma drained onTues. (very tramatic experience).
I have another test for the gut motility issues next Wed.  It is not a pleasant test but neccessary.  I failed the sitz marker test, all the xray markers were still in my intestines after 4 days. 
Michelle ><>
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Veteran Member

Date Joined Jun 2005
Total Posts : 1852
   Posted 2/9/2007 9:44 PM (GMT -6)   
Hi Michelle,
    I hope someone will be able to share some personal experience with you on this subject.  I'm sure you've done some research yourself about it, but I was able to find some people who did better on the powder form.  From what I've found it is the same medication but the prefilled has some preservatives added to it as well.  Not sure why that would make a difference but maybe its worth trying?  
    I hope you start feeling better soon Michelle.  My heart goes out to you!
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Regular Member

Date Joined Nov 2006
Total Posts : 162
   Posted 2/10/2007 12:04 PM (GMT -6)   
Hey Michelle!!!
Sorry you are feeling so bad and having such trouble.  about pre-filled vs. powder, I can only give my experience.  I have been on the pre-filled for about 2 months and have been on Avonex since Nov.11,2006.
At first I was having a lot of pain, chills and fever and extreme sleepiness and tiredness.  That last one is pretty good and I hope it doesn't go away.  Since I've been on the pre-filled the side effect seem to not bother me as much.  I can't say f this is because I've been on the med for 4 months or because I'm tolerating it better in the pre-filled form.  I have heard that sometimes the side effects are less in the powder form but that hasn't been my experience.  My advice (such as it is) is to try it.  What have u got to lose?  I hope this has helped and has made sense.  My mind is a little foggy today.  Be assured that I am keeping u and all of my other healingwell buddys in my prayers.
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