That's quite all right dearheart, I completely understand.
Now to answer your question:
I had no idea that Tysabri can actually improve your existing symptoms (if not permanent). Do you know how it does that?
Remember, I'm not a doctor (even though some people think I play one on TV-heehee), but this is my own theory of how Tysabri works...
In Multiple Sclerosis, damaging inflammation cells (T- cells) cross the Blood Brain Barrier (BBB) where they enter our Central Nervous System (CNS), and see our myelin as foreign and they attack it... which results in scarring (lesions) and damage (i.e., the symptoms we feel).
Tysabri has been designed as a Selective Adhesion Molecule (SAM) that specifically attaches itself to the damaging T-cells which prevents a majority of them from crossing the thin BBB, thereby halting (or greatly reducing) the cascading effects of the damaging T cells from reaching our CNS and destroying our myelin. And even if a few of those pesky T-cells did manage to cross the BBB and get into our CNS, Tysabri has the ability to migrate (move) these T-cells away from our myelin, giving us added protection.
This in turn allows our bodies the opportunity to rebalance our own immune systems, resulting in the body healing itself from the damaging effects done by the bombardment of T-cells in our CNS (i.e., allows for regeneration of nerve cells, axons, nerve receptors, etc.), providing the damage is not permanent.
A really good explanation of how Tysabri works is to view a short three-minute video which can be found at: http://www.mspatientsforchoice.org/AMI.wmv
This is another reason why I firmly believe that early intervention with Tysabri will be extremely beneficial in reducing relapses, slowing/stopping the disease process, and really giving our bodies a fighting chance to live as "normal" a life as possible until a cure can be found for MS.
For proven data Re: improved EDSS scores, improved vision loss, improved cognitive function, and improved Quality of Life data, etc., see:
That ought to be enough reading material for a while, huh? LOL
Take care Shar, and a wonderful, safe, happy 4th to you and everyone tomorrow -
PS: yes, the Touch protocol for Tysabri requires a pre-requisite gadolinium MRI of the brain to be used as a baseline for measuring any future MRIs, if needed.
Our todays are only stepping stones for our tomorrows.
You can visit My Tysabri Diary by going to: http://lauren-livingwithms-aolcomlglbgl2003.blogspot.com/
Post Edited (msladyinca) : 7/4/2007 12:26:45 PM (GMT-6)