I was also scared of the lumbar puncture, but overall it was not big deal as G pointed out. A bit of discomfort during the procedure and then having to lay flat in bed throughout the rest of the day and evening. Mine also supported my diagnosis.
Diagnosed April 2007
Started betaseron -- May 2007 -- experienced allergic reactions after 2 weeks
Started copaxone -- June 2007 -- stopped after 4 1/2 months;experienced severe 5 IPIR's
Started tysabri -- December 2007
Stopped tysabri -- April 2008 (developed antibodies/severe reactions)