I was actually discouraged to read your post. Have you had the problem for the entire 2 years you have been on copaxone? How do you find places to inject?
Have taken the prednisone for 2 days (which I really dislike; not sleeping), and I have not had another IPIR (knock on wood), but still have experienced huge welts. They come immediately after injecting the med, disappear after an hour and then reappear the next day. I think when I had my second IPIR I injected into a vein -- had more bleeding and now an ugly bruise. The welts are about 3 inches long. They hurt for a few days, then itch, and then fade into bruises which are taking forever to go away. I also have lumps under each site which seem to be gradually shrinking.
I have tried manual injection (bigger welts), claritan, benadryl, adjusting the depth, ice and heatt, heat and ice... I am currenly using witch hazel (tucks wipes) instead of the alcohol wipes.
I have only been on this for 6 weeks. One nurse at Shared Solutions told me that for many people the problem gets better after 3 months; another told me 5-6 months.
Have you talked to your doctor?
Diagnosed April 2007