I have been taking Copaxone for 6 years now. I was originally doing the 20mg 7 days a week, then I got lazy - knowing that the 40mg was available I actually just did a double shot every 2 days, still alternating injection sites. Eventually I got the 40mg and do the shots 3 times a week like prescribed.
I have had the flushing and tight chest now 3 times total. It seems to be random, but perhaps is linked to when I get more in a vein than in the fat under the skin.
Yesterday I did my left arm and had the worst reaction to date. I immediately had a "wave" of pins and needles move from my scalp to the back of my head and ears to my upper back and chest. Then I had the flushing and tight chest. 30 to 40 minutes later I started feeling achy in my groin and then my feet and hands and wrists. Then I got real cold and started chattering. Seeing others online like this forum I figured I would state that my cold chills also lasted about
2 hours. I took a hot bath and felt better, but needed to stay in the water.
Regarding the welts, my welts were horrible but really subsided after 4 to 6 months, and to this day simply do not inject in my legs ever. I just rotate from right arm, left arm, left hip, left stomach, right stomach, right hip and right arm.