coming off 6 mp

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Regular Member

Date Joined Jun 2010
Total Posts : 86
   Posted 3/24/2011 12:16 PM (GMT -6)   
I was on 6 mp for 5 years and came off when my colon was removed anyone else with any side effects or issues coming off it?

Veteran Member

Date Joined Aug 2006
Total Posts : 6571
   Posted 3/24/2011 12:50 PM (GMT -6)   
they should take you off slowly. you might have some headaches, but i didnt have anything big

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Date Joined Aug 2008
Total Posts : 5975
   Posted 3/24/2011 1:03 PM (GMT -6)   
     I was on it for seven years and my GI doctor took me off it two weeks prior to starting Remicade.  I didn't notice any difference.  All meds failed and I had my operation last June 28th.

Regular Member

Date Joined Nov 2010
Total Posts : 111
   Posted 3/24/2011 1:39 PM (GMT -6)   
If I recall I went off it cold turkey and that was fine. My doctor always told me 6-MP takes about three months to start working because your body "notices" its effects very slowly. I would assume it would be the same (in reverse) going off of it.
Diagnosed with UC in 2007
Flare in 2007 causing anemia requiring blood transfusions, eventually controlled by asacol and 6-MP.
Flared again in 2009 as 6-MP lost effectiveness, went on TPN and received more blood. Started Remicade, which induced remission.
Flared 2010; Remicade no longer effective.
Had 1st surgery of 3 step j-pouch at CC on 1/19/11. 2nd slated for April, and j-pouch in July!

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Date Joined Feb 2011
Total Posts : 1059
   Posted 3/24/2011 1:54 PM (GMT -6)   
I stopped it for a year and did it suddenly, no reducing doses. I presumed that I would get less colds and chest infections as whilst on it would catch every cold going round. Ironically I had more colds and chest infections and even laryngitis for a month during the year I was off it. My GI said he wasn't surprised and he implied it can take a long time for some people to improve their immune system.

Anyway back on it now as huge flare up of CD and will stay on it from now on and also taking Humira and pred.
Crohn's dx 1989, loop ileo 1992, end ileo 1992. Arthritis developed 1990 Stoma abcess 1995. Azathioprine started 1995. Panprocolorectomy 1999. Stillbirth 2000, antiphospholipid syndrome dx 2000. Flare up 2004, stoma abcess and strictoplasty 2004. Low blood pressure dx with impaired kidney function 2006, fludrocortisone pres. flare up 2010, steroids, Humira, codeine.

Veteran Member

Date Joined Feb 2006
Total Posts : 5698
   Posted 3/24/2011 2:09 PM (GMT -6)   
I also went off it cold turkey, no problem. I don't think this is a drug that needs to be weaned from.


Veteran Member

Date Joined Oct 2009
Total Posts : 1054
   Posted 3/24/2011 5:35 PM (GMT -6)   
Ditto to everyone above.

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Date Joined Aug 2006
Total Posts : 6571
   Posted 3/24/2011 10:54 PM (GMT -6)   
actually after i thought about it, it was the immuran i had to be taken off of slowly, but they are pretty close to the same thing.  I'm not sure why they told me that, but two GI's and  my regular dr all said it was best to go off it slowly, and it can take up to 6 months to get out of your system.
I thought i would get less colds too, but i was sick more often, but i think it was because while i was on the immuran/6mp i was very careful about handwashing, and staying away from anyone with a cold, all that, because i knew it weakened my immune system and afterwards, while i still wash my hands and such, i wasn't as careful
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