I started on Akineteon too - found them useless and since been on Stalevo + Sifrol ... much better now, but still not great. Yes things can happen all of a sudden. And slowly too - at different times.It's go a mind of its own. I was diagnosed in 2003. I have simliar symptoms. I am currently investigating a place in Germany that claims to have an 80% almost cure rate. They charge about 25,000 Euros for the treatment. I have only just started to talk with them. Let me know if this helps.