Less meds taken due to sleep time. My wife is wheelchair bound with very little diskynesia. She is subject to orthostatic hypotension, has been through 3 studies at the NIH for this problem the first 8 years ago and the latest 3 months ago. meds are carbidopa/levodopa 25/100 3 times a day, midodrine and fluronef for orthostatic hypotension, sertraline fo depresion, and macrodantin to avoid UTI. She was diagnosed in 1994.