Posted 10/27/2010 8:36 AM (GMT -7)
Sigh....
Jeff (the one with the leaky winkie)
Posted 10/28/2010 8:35 AM (GMT -7)

This goes out to notme. 

I'm just starting down the Trimix road.  I've received 2 injections and the last one was painful and lasted 3 hrs.  I'll have to discuss the dosage and ratios with my Urol. next visit but would like to get the smaller needles.  I saw your posting re: 33 guage 1/2 in. needles and clicked on the supply thread.  I found the needles under TSK but couldn't locate the syringes that are compatible. 

Sorry for the ignorance but this is all new to me.  I haven't purchased Trimix yet since my Dr. supplied the Trimix as samples.

Thanks

 

 

Posted 10/28/2010 12:40 PM (GMT -7)
Hi Nopro,

There is not a big diameter diff between 30, 31 or 33, but there is a big diff in flexibility, 30 bends pretty easy and I stayed with that and have no issues. I tried 31 gauge and the only diff was it bent very easy , to easy when trying to fill it. It felt the same as the 30 when injecting

Try to get a brand that works with an auto-injector. I use the BD inject-ease. It makes the process much easier, safer and less chance of getting the willies from seeing a needle enter your skin as you never see the tip at all. Click and your in, perfect placement every time

The Inject-ease also has depth adapter rings so you can tailor the depth to exactly what you need. here is a link as an example

www.phoenix5.org/sexaids/injections/automanny.html
Posted 11/13/2010 9:46 AM (GMT -7)

Well, I got my 1st vial of Trimix, 30 guage, 1 inch needles, and the BD Inject Ease auto injector.

I gotta say that this has made the whole process a lot easier.  My 1st effort was almost comical since I was trying to inject in the left side of my penis and was shaking so badly from nerves of the unknown, that the injector was moving about an inch along the unit.  I finally used two hands to steady and was able to hit the mark.

The BD unit has a spacer that allows the user to shorten the needle penetration to 3/8 inch.  This worked great for me and there's no pain at injection and I achieve an erection within 5 to 10 minutes.  I have been using .3ml or 3.5ml of Trimix and the erections last 60 to 75 minutes.  I expect that I'll be able to cut this down over time as others have stated that Trimix seems to work better with time.

I've noticed that erections last longer when injection is in the right side than the left and take slightly longer to achieve erection.  Right injections are also more uncomfortable afterwards (I'm figuring that this is due to the nerves healing differently on one side to the other).

I haven't had a orgasm yet and I'm hoping that this will start up pretty soon.  Is anyone in my boat or did most of you experience orgasms right away?  The head of my penis isn't uniform in color like before and is paler on the bottom than the top.  The Trimix injections seem to be helping slowly change this and perhaps the nerves haven't come back enough to stimulate an orgasm. Any feedback?

   


Age 65

Diagnosed 4/10; 4 sites involved; Gleason scores: 7 & 8

open radical prostatectomy 6/10; da Vinci ruled out

Post surgical PSA of .1 taken 9/10; lymphs & margins not involved
Continent in 4 mos. Small pads worn for long activities (golf,etc.)
Levitra not effective
Posted 11/14/2010 2:20 PM (GMT -7)
I must correct my last post.  They were 30 guage 1/2 inch needles not 1 inch.

Age 65

Diagnosed 4/10; 4 sites involved; Gleason scores: 7 & 8

open radical prostatectomy 6/10; da Vinci ruled out

Post surgical PSA of .1 taken 9/10; lymphs & margins not involved
Continent in 4 mos. Small pads worn for long activities (golf,etc.)
Levitra not effective
Posted 11/14/2010 2:35 PM (GMT -7)
NoPro,

The Trimix injections seem to be helping slowly change this and perhaps the nerves haven't come back enough to stimulate an orgasm. Any feedback? said...


Yes some feedback for you - and I hope it makes your day (and all your remaining days). The nerves required for producing an erection are not related to those needed to have an orgasm. So this is your lucky day, yes? Of course it is easier to produce an orgasm with some degree of erection (any way you can produce it). Can be done with a limpy even -- but not very easily (at least not for me). Also the stimulus for orgasm is mostly in your head but, yeah nerves in the penis have to contribute -- just not the erection nerves.

For me I find the Pump as the best way to have enough hardness to help in the orgasms department .. that plus dear wife rooting me on and helping out. I am not a trimix guy so can't comment on that but plenty who are already have.

So go forth ... and go forth some more!

One last thing for you and others. All of your posts are perpetually editable by clicking the little pencil thingy up in the right hand corner. Edit, add to .. delete .. u name it. You just have to be logged in again to get the pencil to show up.

Post Edited (JStars) : 11/14/2010 2:53:38 PM (GMT-7)

Posted 11/15/2010 12:41 PM (GMT -7)
JStars
 
Thanks for the input.  I thought that all the nerves were interrelated.  The lack of semen after prostatectomy may be hindering my progress toward achieving orgasm, at least mentally.  That release always was so satisfying.
 
How come you haven't tried Trimix?  I think I'll be fine with it once I get the proper dosage.  The injection with the BD Inject Ease, 30 guage, and 3/8 in. depth (with 1/4 inch spacer) made it a painless process.  


Age 65

Diagnosed 4/10; 4 sites involved; Gleason scores: 7 & 8

open radical prostatectomy 6/10; da Vinci ruled out

Post surgical PSA of .1 taken 9/10; lymphs & margins not involved
Continent in 4 mos. Small pads worn for long activities (golf,etc.)
Levitra not effective
Posted 2/21/2011 4:37 PM (GMT -7)
Following successful DaVinci prostate surgery in 2006 I have been using a Trimix of 150-10-150 with 30 gauge Insulin needles. After an initial failure with Viagra Cialis and Caverjerct, my MD put me on Trimix. 40 units worked fairly well for a while and I started to increase dosage without impact. In fact higher dosage seems to be less effective.

The suggestions here seem helpful before I go to my MD and ask for a new formulation
Pretake Viagra
Stimulate before and after insertion
lower does to about 40units.
Look into autoejector


HAS ANYONE HAD SUCCESS WITH MODIFYING MIX?

I do refrigerate and wonder if anyone has had success traveling with preloaded syringes ( keep in cooled syroform in suitcase)
I've used a bottle well beyond 3 month expiration although it does seem to lose some potency after 3-6 mos.
Posted 2/21/2011 4:51 PM (GMT -7)
musicmoney, welcome to the Forum. You sure have a strange- to us- ration going there. Most here use a 30mg/1mg/20mcg (or 10mcg) Trimix formula. Yours, if correctly typed seems to be 5 times as strong in the normal stuff and 7 times as strong in the alprostadil end, which provides much of the punch of the drugs. Is that right? At the 40 units level, that seems an enormous amount to use, especially to just get 'fairly well' results. I'd be interested in what exactly is on the bottle itself?

As to changes, I see you mention massage before and after, but are you familiar with our almost patented, tried and mostly true pump and prick method of pumping the penis up about 30% using a ring or some kind of constriction top hold the blood in, then injecting and gently massaging for 3 minutes before releasing the ring and allowing the blood (and the drugs) to run out of the penis? If not, thats a great technique to get maximum adsorption of the drugs into the penis..
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 12/10-.09, 02/11-.08
ED-total-Bimix 30cc
Posted 2/21/2011 5:16 PM (GMT -7)
Thx for response...I noticed that. The Bottle from a compounding pharmacy in Maine via my Boston MD says
trimix 150mg-10mg-150mcg
Posted 3/5/2011 9:13 AM (GMT -7)
Hey NoPro,

You asked me a while back ...

How come you haven't tried Trimix? I think I'll be fine with it once I get the proper dosage. The injection with the BD Inject Ease, 30 guage, and 3/8 in. depth (with 1/4 inch spacer) made it a painless process. said...


Well, after reading about Trimix Freeze Dried on another thread,Light Dawned and I said to myself - "Hey, I've got a whole BOX of Freeze Dried Trimix from Amer Pharma Solutions!".
That made a strength of about 10mcgPap, 3mcgPhen,50mcgPGE-1 in 30ml -- A bit strong on the PGE and very weak on the other two ( yeah those are really mcg not mg levels per ml). But using .20 ml at that strength is working very nice with 2+ hr erections and good chubbies long after that -- and ZERO ache.

So one long time pumper is sold on injections. Also at a calculated 60 cents per injection (very conservative 100 shots per bottle including trimix($30), water($5), needles($20), alcohol wipe($5) costs) that is right up there with ADC double pills price per (which don't work anyways).

So things are looking up here .. yep.

J

Post Edited (JStars) : 3/6/2011 4:35:10 AM (GMT-7)

Posted 8/8/2011 7:27 AM (GMT -7)
I just joined this forum and have been reading previous threads about Trimix. I just began treatment last month and have had limited success. I am using 3 mil now but will continue up to 4 mil if necessary. My urol has set that limit. I find that after injection I get a positive response, but while in the act of intercourse loose my erection. When I stand up the erection returns. Is this due to increased blood flow while standing?
Posted 8/8/2011 8:49 AM (GMT -7)
Hi Island Guy
 
I started my TRIMIX injections from my URO last week and the first shot is his office was .3ml and I got to about 60% erection. He told me to try at home with a .4ml and then go up .05ml until I find the correct dose that gets an erection strong enough to use for penetration and lasts no more than an hour and a half. He didn't give me a high limit. Saturday I injected the .4ml dose and got to maybe 70% while standing but as soon as I joined my wife in bed it went down some and was worthless. I will try a .45ml dose later this week and see how that goes. Another in here suggested I look into a penis constriction ring to keep the blood in while I am not standing. Living in Alabama all the adult toy stores have been run out of business so my URO suggested a Hardware store bought rubber "O" as long as isn't too tight for the blood loss problem which he thinks is from my "spared" nerves still not over the RALP trauma. I shall see later this week.  turn
 
Terry the Water Guy
AGE 61 with family hist of PC
PSA
2.5 6/10
3.5 12/10
5.25 3/11 all DRE Neg

BX 4/13/11 2 of 12 cores diag both sides 15% & 20% GS7(3+4)
RALP nerve-sparing 6/8/11 path G7 pT2C, Marg-Lymph-Sem NEG, organ confined 60% tumor involved 69grms 4.3X4X3 cm
Cath removed 6/15 dry 7/1 waiting on first post PSA end of Aug.

8/4/11 start TRIMIX inject therapy for ED
Posted 8/8/2011 5:57 PM (GMT -7)
I'd keep upping your dose in small increments, you might just find the magic number, I did. My first tries at 0.50 cc of trimix were almost there, 0.55 was really good, 0.60 was granite so I think 0.55 will and did do the trick.

I don't think you'll find an O-ring that will work, they just aren't stretchy enough so you'll end up with one that is too big and thus fails to constrict enough. Some guys in my PSA group use office style rubber bands and have had good success. You may need to double them over a few times and they can be cut off easily if you need relief. You might want to do some pruning first though to avoid a tangled mess. turn
PSA 5.6 - 04/2010 - DRE positive
PSA 6.7 - 09/2010
Biopsy - 09/2010 - Age 53
T2b/c Gleason 7, 4+3
PSA 8.2 - 12/2010
RRP - 12/2010
pT3a, Gleason 7, 3+4, 20% PCa
pNO
Negative margins and seminal vesicles
RP 37.3 g
No further treatment recommended.
PSA <0.01 - 03/2011 - 3 month post-op
PSA <0.01 - 06/2011 - 6 month post-op
Posted 3/23/2012 1:47 PM (GMT -7)
.o2 to .03 of trimix is good for me
Posted 1/19/2014 5:46 PM (GMT -7)
I'm glad I found this place.

Hope no one minds I don't have PC but do have ED and for heart reasons don't want to risk the pills. This is the only place I have found with any info on trimix.

I'm ready to throw the trimix in the bushes :)

Just started in late Dec and have only tried it 5 times.
Thought I'd share my results.

Worked in the uro's office. Based on his evaluation and the results of a small dose I was prescribed a .03 ml dose.

Reluctant to actually put a needle there myself even with the auto injector and reading about ER trips here, it stayed in the fridge for a while.

So when I get the nerve to do this I decided to try .01 ml ,again after reading here and not wanting an er visit, I reduced the prescribed dose. It worked 1 hour 15 mins. Woo who.

2nd time same result but a bit of pain. (Side note be sure to use the bathroom before injecting.) I had to pee in the shower cause it wasn't bending over! But this works great what's all the fuss about.

3rd try was a flop, it worked for 15 minutes. I figured maybe I missed???

4th try. I learned I did not miss on the 3rd try because I really missed this time.Didn't have the auto injector pointed straight down. It was pointed directly for center. When I shifted it up it moved to far right and injected just under the skin. Obviously it didn't work. No pain but I have a big purple bruise. Really Big purple murple.

5th try today. I self injected, cause the auto injector now scares me :)
No dice.

All at the .01ml

Going to slowly increase the amount in the future and hope for the best.

Thanks for all those who have posted on this topic. I think .01ml may not be enough but .03 may be to much.
Posted 1/19/2014 9:37 PM (GMT -7)
Murple,

You said it stayed in the fridge for "a while" -- how long is that? Trimix loses some of its strength after a few months in the fridge. I'm a bit confused about how much volume you are injecting. 0.01 ml is one "unit" on an insulin syringe (like you and I are using) and my syringes hold 50 units. I'm not sure I could reliably inject that little -- it would represent something like a 1mm motion of the plunger. Did you mean 0.1 ml (10 units?) I've never heard of anyone injecting 1 unit of anything.

I have an autoinjector. I used it for a while but the positioning is a bit problematical sometimes. It usually works better to man up and jab yourself manually. I use a 30 gauge needle (you may have to ask) and it seems more comfortable. Be sure to avoid injecting at the 12 o'clock position (right on top) and don't go past half way down the side. Stick to 1-3 O'clock on the one side and 9-11 O'clock on the other.

Don't get discouraged. It takes a while to zero in sometimes. As I understand it your doctor would be OK with you going up a bit (gradually and carefully, trying each dose twice) until you find what works.

Welcome to the forum, by the way. Hope we can help out.
60
Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012:
1)neg (some inflammation),
2)neg,
3)positive 1 of 14 GS6(3+3) 3-4%, 2nd opinion GS7(3+4)
4)neg.
Mild Pre-op ED
DaVinci RRP 6/14/12. left nerve spared
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
Start 24 mo ADT3 7/26/12
Adjuvant IMRT 66.6 Gy 10/17/12 - 12/13/12
Leaky but better, Trimix, VED
Forum Moderator - Not a Medical Professional
Posted 1/20/2014 10:08 AM (GMT -7)
Peter,
Yes I meant 10 units. This terminology is new to me.

I'm going to call the Doc tomorrow and ask his thoughts on how much I should up it. Was cleared for 30 units. But I want to get there slowly since 10 worked the first 2'times.

It was only in the fridge for 3 weeks so I think that is not my problem. Says it doesn't expire til April.
Posted 1/20/2014 10:41 AM (GMT -7)
Murple,

Adrenaline tends to counteract the effect of the trimix (so you need a larger dosage). Every guy is freaked out injecting in the doctor's office so 30 units is your so-nervous-my-head-may-explode dosage. You may have let that first failure throw you and become anxious. That'll make your dosage required go up.

Do try to relax. You will find a dose that works reliably. Ask your doctor about how fast to increase your dose. Often going up by 20% is about right. 120 percent of 10 is 12. 120 percent of 12 is 15 (you round up to the next unit).

Good luck. It will work for you.
60
Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012:
1)neg (some inflammation),
2)neg,
3)positive 1 of 14 GS6(3+3) 3-4%, 2nd opinion GS7(3+4)
4)neg.
Mild Pre-op ED
DaVinci RRP 6/14/12. left nerve spared
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
Start 24 mo ADT3 7/26/12
Adjuvant IMRT 66.6 Gy 10/17/12 - 12/13/12
Leaky but better, Trimix, VED
Forum Moderator - Not a Medical Professional
Posted 1/21/2014 8:43 AM (GMT -7)
7 months out from surgery and the cialis/staxyn is not helping to achieve anything close to a penetrating result. At my 6 month checkup, I brought up trimix and the doc asked if I wanted to try but I thought I'd wait until my next checkup.

I tried using a ring along with the cialis in hopes that it would help but it did not. I have thought about trying a pump between now and my trimix venture. Did any of you try a pump before the trimix? Should I just forget about trying a pump?
55 yrs old
PSA Nov 2012 - 2.8 Primary care doc said it was high for my age
PSA Mar 2013 - 3.8, 2nd 3.2
Biopsy 4-3-13, 3/12 15%, 8%, & 40% 3+3
DaVinci prostatectomy Dr. David Cuellar, 6-10-13
Final diagnosis Prostatic Adencarcinoma, Gleason 7 (3+4)
prostate size 21 grams
3.5 cm x 1.8 x 0.8
40% involved by tumor
margins uninvolved
staging: pT2c
9-14-13: <0.1
12-19-13: <0.1
Posted 1/21/2014 4:12 PM (GMT -7)
Thanks again Peter.
Spoke to the Doc today. He wants me to go to the original .3 dose and try that.

I like your math better and from what I've read on the site small changes can make big differences. I'm going with the 20% increment method.

txrick,
Absolutely no expert here but for me the pump enlarged things but not enough for penetration. Your experience may be different.

While I was complaining above about the reactions or lack there of I have confidence it will work once I get worked out. In my experience the thought of the injection is 1000 times worse than the actual injection. With the auto injector there was zero pain. Self injecting it was just a small pinch.

Again I'm new to this so.....don't take my word for anything.

Post Edited (Murple) : 1/21/2014 4:16:32 PM (GMT-7)

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