I am currently on Intermittent Triple Androgen Blockade Therapy under the direction of Dr Steven Tucker in Singapore. 10-months into the 1-year course using Zoldadex, Casodex, and Avodart (I believe Dr Leibowitz prefers Proscar).
Initial PSA was 19.2 and currently 0.033 (May 2008).
Negative aspects of treatment: Medically castrated, muzzy feeling quite a lot of the time, get tired quite easily. I have not experienced other possible effects like "hot flashes", at least not significantly. Not a standard treatment recommended by most doctors. Expensive medication (but I buy cheaper generic versions of Casodex and Avodart).
Positive aspects of treatment: Most if not all of the negative effects are reversable when I stop taking the medication (not so with standard treatments). I hope to delay the necessity for more radical treatment in the hope that better treatments will be developed. Survival prognosis is at least as good if not better than radical treatments over 8 years.
So far I'm pleased the way things are going with TAB. Let me know if you need any more info.
Diagnosed: June 2007. Aged 61. PSA 19.6. DRE negative.
Biopsy: June 2007; 2 cores of 18 positive.
MRI and Bone Scan: Negative.
Pathology: 5% of 1 core, "Small focus" in another core +ve.
Gleason 3 + 3 = 6.
Clinical: PCa considered confined to prostate. Stage T1c.
Treatment: After considering RP and HD Brachy, decided on Intermittent Triple Androgen Blockade Therapy for 1-year, using ZOLADEX, CASODEX 150 mg/day, AVODART 0.5 mg/day. Start PSA 19.2 (July 2007).
Current Status: PSA 0.033 (May 2008) - PSA nadir.