does too much estrogen in men cause prostate cancer?

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Regular Member

Date Joined Oct 2007
Total Posts : 94
   Posted 2/24/2008 3:57 PM (GMT -6)   
It would be good advice for those more information on this subject to look over the Study by the Journal of Clinical Indocrinology & Metabolism  and the  report by the Analyst --Internet Health report ---Treatment  with Dim.
In two papers   published by the Journal of Biological Chemistery (March27,2003) researchers report that DIM significantly haulted proliferation of androgen-dependent human prostate cells.  In one of the Studies human prostate cells treated with DIM grew 70% less than angrogen-dependent untreated cells.  DIM  also  inhibited di-hydrotesterone (DHT) stimulation of DNA synthesis in the angrogen-dependent cancer cells
Recent studies show that estradiol, the active form of estrogen provokes increase in prostate specific antigen PSA in human prostate tissue.  This increase in PSA is as great that seen with testosterone.  Increased PSA production was specifically inhibited by by 2-methoxyestradiol,---the beneficial estrogen metabolite whose production is promoted by DIM.
In 1997, Researchers at Strang Cancer Research Laboratory at Rockeffer University discovered that Dim changes "strong" estrogent into "weak" estrogen, it stops human cancer cells from growing  and provokes the cells to self-distruct (apoptosis) . Subsequent test at the University of California (Berkeley) sho that DIM inhibits some human cancer cells from growing, by as much as 90%.
I thought that this infomation was very important, so I am passing it along to all in this forum.

age 68
diag 10/07/2007
Gleason 3+3=6
prostate 66gm
13biopsies, 3pos.
Have selected the Davinci proedure, to be done in Feb. 2008


Post Edited (siberian) : 3/28/2008 11:39:00 AM (GMT-6)

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 3/12/2008 8:52 PM (GMT -6)   
I don't see a reason for this change either, but I can do it if you like. Tell me what to change it to.

On the topic,
It's an interesting topic because of what I know about treating advanced prostate cancer. ADDING Estrogen is actually a treatment option to those who have androgen independant prostate cancer. That process is called DES and is very well known to have a positive effect against prostate cancer (Must be the good Estrogen). Cruciferous vegetables like broccoli are rich in selenium and can also produce DIM. Although almost all studies focus on the selenium when talk prostate cancer suppliments. What's more, In the old days estrogen was the number one treatment for prostate cancer but it can kill from it's side effects almost as many as it helps. I guess that would mean reducing estrogen is good unless you have advanced disease and other options are not working.

Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007
Post-Op Pathology: Gleason 4+3=7, positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (1/08): <0.1
I will continue HT until May '09. 
Visit my Journey at:
Prostate Cancer Forum Moderator

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