Brother on Lupron

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goodsister
New Member


Date Joined Mar 2008
Total Posts : 5
   Posted 3/25/2008 11:40 PM (GMT -7)   
My brother has been on Lupron for almost 6 months now, and his PSA levels have dropped from 50 to nearly 0. That's the good news. But the Lupron seems to be making him lose his mind, he's become irrational and angry almost to the point of mania. I realize he's under a lot of stress having prostate cancer, but he's not himself. I'm wondering if anyone can share their experiences with Lupron and how it has affected them emotionally. I have read that it causes depression, but in my brother it seems to be worst than that. We do have a family history of depression and schizophrenia, and I'm wondering if the Lupron could possibly have triggered a psychological reaction. Thanks for any insight.

Tony Crispino
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   Posted 3/25/2008 11:45 PM (GMT -7)   
 

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Tony Crispino
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   Posted 3/25/2008 11:46 PM (GMT -7)   

tongue  Hi ~ goodsister & Loved Ones…

 

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Tony Crispino
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Date Joined Dec 2006
Total Posts : 8122
   Posted 3/25/2008 11:54 PM (GMT -7)   
Hi goodsister,
First I love your screen name, because on it's own being here it's obviously true. Welcome to the best site on the web for patient to patient interaction. I too am a patient. I have been on Lupron for nearly a year. I have suffered mild effects, but others not so lucky. I could do without this drug, but I know I need it. And you brother is doing well with it, per se that his PSA is lowered. But it needs to be understood, Androgen Deprivation Therapy (ADT) can cause mood swings, depression, and sometime complete withdrawl from supporters. I've seen it here, and I pray for those it effects that way. Your brothers personality changes could indeed be from ADT. And he may be showing signs of depression. The effect of knowing you have serious disease and not adapting well to treatment can trigger other psychological reactions. For me, I am keepin' on OK. I make jokes about it and take it lightly. I am fortunate to be able to do so.

Tony
Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007
Post-Op Pathology: Gleason 4+3=7, positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (1/08): <0.1
I will continue HT until May '09. 
Years in Remission (3/23/07): 1
Visit my Journey at:
 
STAY POSITIVE!
 
Prostate Cancer Forum Moderator


Swimom
Veteran Member


Date Joined Apr 2006
Total Posts : 1732
   Posted 3/26/2008 6:15 AM (GMT -7)   
Goodsis,

Give your brother's Oncologist a call. It is part of his / her job to oversee some of these side effects. Being thrown into acute hypogonadism is as bad as being thrown into acute menopause. In fact, it's pretty much the same. That sudden loss of hormones carries a wicked punch. Been there myself and wouldn't wish it on any man OR woman. Give the Doc a call. An antidepressant may help a lot. Good luck and hang in there Sis.

Swim
 


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1463
   Posted 3/26/2008 11:38 AM (GMT -7)   
Hey Goodsister,

Please see your doc about the depression from the low testosterone. I went through that after surgery and it can be devastating like Swim said. There are meds that can help and will not interfere with his treatment.

Good luck and please stay with us...

Jim
Age 73. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
PSAs from  1/3/07 - 1/17/08 0.00. 
Next PSA test on 7/17/08
"Patience is essential, attitude is everything."
 


goodsister
New Member


Date Joined Mar 2008
Total Posts : 5
   Posted 3/26/2008 7:41 PM (GMT -7)   
Thank you everyone. I am going to call his doctor to discuss, as you advise. I have suggested to my brother that the Lupron could be causing what he calls "feeling the cancer coursing through his body", and also his mood/personality change, but he'll have none of it. He refuses to talk to the doctor about it. So, I will. Thank you for your support, and good wishes to you all too!

Lynne
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