Ok, bimix and trimix guys, please offer your input

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DanmanBob
Regular Member


Date Joined Feb 2008
Total Posts : 467
   Posted 4/15/2008 6:50 PM (GMT -6)   
Doc told me a month ago he was ok with me taking Caverject, bimix or trimix.
 
I requested 30/1 bimix, which he said he will agree to but suggested that I use a 30/6/20 trimix instead.  Franck's told me the "standard" trimix is 30/1/10 (the PGE being the third number listed).
 
Doc said the bimix has a higher incidence of priapism and fibrosis than the trimix....but he left the final decision to me.
 
For those who take trimix, what formula do you use?
 
For anyone with an opinion, any thoughts on this?
 
One final comment.  He said if I try the trimix and have issues with it, I could still try the bimix.
 
I am leaning toward starting with bimix because of what folks here have said about pain from PGE.
 
Help!!!!!


Danman Bob
Age 57
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14
Biopsy result - 9 of 12 sticks showed cancer
Despite high Gleason score, cancer was confined to the prostate
Possible post-surgery radiation therapy...decision likely in late April 2008, depending upon PSA at that time
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of March 2008)
Began using Viagra 3 times a week December 2007 to stimulate blood flow
Began using Osbon Erec-Aid Esteem manual pump for therapy mid-February 2008
Will probably begin using bimix injections in addition to Viagra and pump in May 2008


BillyMac
Veteran Member


Date Joined Feb 2008
Total Posts : 1858
   Posted 4/15/2008 7:12 PM (GMT -6)   
DanmanBob
I don't have any input regarding a comparison of the two but like you I am a little disconcerted by the posts of trouble and pain with Trimix. I have decided to go with the Bimix 30/1 initially and start the dose very low and, depending on the reaction, slowly build up. If I have no great success with the BimixI will switch to Trimix and go through the same procedure.
Bill
1/05 PSA----2.9 3/06-----3.2 3/07-------4.1 5/07------3.9 All negative DREs
Aged 59 when diagnosed
Biopsy 6/07----4 of 10 cores positive for Adenocarcinoma-------bummer!
Core 1 <5%, core 2----50%, core 3----60%, core 4----50%
Biopsy Pathologist's comment:
Gleason 4+3=7 (80% grade 4) Stage T2c
Neither extracapsular nor perineural invasion is identified
CT scan and Bone scan show no evidence of metastases
Da Vinci RP Aug 10th 2007
Post-op pathology:
Positive for perineural invasion and 1 small focal extension
Negative at surgical margins, negative node and negative vesicle involvement
Some 4+4=8 identified ........upgraded to Gleason 8
PSA Oct 07 <0.1 undetectable
PSA Jan 08 <0.1 undetectable


DanmanBob
Regular Member


Date Joined Feb 2008
Total Posts : 467
   Posted 4/15/2008 8:13 PM (GMT -6)   

Thanks, Billy.

I hope others will offer some comments, as well.

DanMan


Danman Bob
Age 57
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14
Biopsy result - 9 of 12 sticks showed cancer
Despite high Gleason score, cancer was confined to the prostate
Possible post-surgery radiation therapy...decision likely in late April 2008, depending upon PSA at that time
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of March 2008)
Began using Viagra 3 times a week December 2007 to stimulate blood flow
Began using Osbon Erec-Aid Esteem manual pump for therapy mid-February 2008
Will probably begin using bimix injections in addition to Viagra and pump in May 2008


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1464
   Posted 4/15/2008 10:00 PM (GMT -6)   
Hey Danman,

Trimix is all I have used so can't compare them. I have no pain with Trimix since I got the dose right. Docs seem to start to high, at least mine did. .1cc was way too much and after much experimenting I now take about .03 cc. No pain, stays up for about an hour, works great. I also take 50 mg of Viagra and 1000 mg of L-Arginine about 2 -3 hours before the shot.  Like everything else with this disease, it takes lots of patience and each of us is different in our reaction.

Using only a small of Trimix is easier on the pocket book and on my tender part...

Jim


Age 73. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
PSAs from  1/3/07 - 1/17/08 0.00. 
Next PSA test on 7/17/08
"Patience is essential, attitude is everything."
 
 


DanmanBob
Regular Member


Date Joined Feb 2008
Total Posts : 467
   Posted 4/15/2008 11:08 PM (GMT -6)   

Thanks, Jim.

Do you know which trimix formula you use?


Danman Bob
Age 57
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14
Biopsy result - 9 of 12 sticks showed cancer
Despite high Gleason score, cancer was confined to the prostate
Possible post-surgery radiation therapy...decision likely in late April 2008, depending upon PSA at that time
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of March 2008)
Began using Viagra 3 times a week December 2007 to stimulate blood flow
Began using Osbon Erec-Aid Esteem manual pump for therapy mid-February 2008
Will probably begin using bimix injections in addition to Viagra and pump in May 2008


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1464
   Posted 4/15/2008 11:22 PM (GMT -6)   
Yeah Danman,

Its phentolamine, papave and prostaglandin. I don't know the quantities, its not on the bottle.
Age 73. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + 1000 mg L-Arginine + .03 cc Trimix = Excellent Results
PSAs from  1/3/07 - 1/17/08 0.00. 
Next PSA test on 7/17/08
"Patience is essential, attitude is everything."
 
 


Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 4/16/2008 4:38 AM (GMT -6)   
Hi DanmanBob,
 
I'm in a similar position to you, Gleason 9. But a non nerve-sparing RRP. I'm soon to have a follow-up PSA test, but went to the sex clinic almost two weeks ago, exactly 4 weeks after the operation. Here's a report on what happened:
 
[Deleted to comply with forum rules]
 
So my adventure with Bimix has been a good one. Hope it works out as well for you. Of course we're all different, and your experience may not match mine. But there is room for optimism there -- let's know how it goes. And good luck with the PSA test.


Age 63. Other than cancer, in good health; BMI 20
Pre-op: No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4 of 12 cores
7 March 2008, RRP, non nerve sparing
Two nights in hospital; catheter and staples out after 7 days
Continent, no pads needed from the get-go
Post Op: Stage pT2 M- N-; clear margins and lymph nodes; Gleason 4+4=8; prostate weight: 37gm
6-week PSA: 0 

Post Edited (Piano) : 6/22/2008 12:21:26 AM (GMT-6)


Lungman
Regular Member


Date Joined Jan 2008
Total Posts : 276
   Posted 4/16/2008 8:54 AM (GMT -6)   
I can only comment on BiMix, but it has been successful for me, too much so last time!!!. I encounter no pain or discomfort and the erections are firm. Just my two cents worth.
46 you when diagnosed, now 47
Pre-Op PSA 9.9
1 of 12 cores positive, Gleason 3+3
DaVinci on 9/5/2007
Post-Op Gleason 3+6, Negative Nodes and Margins
Less than 1% of prostate involved with CA
3 Month PSA 0.01, 6 Month PSA 0.01
Incontinence resolved 9/15/2007, one day after cath removal
ED showing significant improvement, more notable over last month
with Viagra 100 mg.
Success with BiMix


Ripandburn
Regular Member


Date Joined Aug 2007
Total Posts : 125
   Posted 4/16/2008 9:13 AM (GMT -6)   
Piano,

Wonderful story.

To all, I initially did the Caverject in the Dr's office. Painful with no good results. I told him I wanted the Bimix or Trimix. He wrote the RX for Bimix. He wanted me to start with .5ml. That was too much. Erect for 2 1/2 hrs. A little scary. I am down to .2ml. That works perfectly........ No problems or complaints, except the initial stick.
52 years old
T1c 3+3=6
DaVinci July 16, 2007
largest cancer .2mm
Bladder Sling installed during prostate removal
nerve sparing with both nerve bundles intact
all cancer contained within prostate nothing near margins
11 weeks post-op - no more pads
3 PSA's all < .1 - Undetectable


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 4/16/2008 4:24 PM (GMT -6)   
I began with Caverject Impulse, unable to use due to pain and aching, then switched to Caverject injectable powder reconstitute.  Again unable to tolerate aching and pain.  Switched to Bimix, having great results.  It takes .5ml to do the deed, but worth it for the results.  a 5ml vial prescription give 10 injections for $57.00
 
James C. 
 
Help support the forums so they can support you:  http://www.healingwell.com/donate 
 
Age 60 
4/19/07   PSA 7.6, referred to Urologist, recheck 6.7
7/11/07   Biopsy- 16 core samples, size of gland around 76 cc. Staging pT2c
7/17/07   Path report:  3 of 16 PCa, 5% involved, left lobe , GS 3/3:6. 
9/24/07   (Open) Retropubic Radical Prostatectomy performed 
9/26/07   Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
10/15/07  ED- begin 50mg Viagra and Vacurect pump nightly, Fully continent
1/14/08  Caverject started/stopped, aching.  2/24/08 .5ml Bimix started-success
3/24/08   ED- 6 mts.-Viagra, pump, no response- Bimix continues
Post-surgery PSA's:  3 mt:0, 6 mt:0,


Tamu
Veteran Member


Date Joined Oct 2006
Total Posts : 626
   Posted 4/16/2008 8:42 PM (GMT -6)   
My Caverjet experience was not good. It was given in the office and I had a two hour drive home. I was miserable the whole way. I reported back to my urologist's PA my experience and he ordered up Bimix. I have never tried Trimix but I have no aching with Bimix, I use about .30 cc's, erection occurs in about 20 minutes and last about two hours before starting to go down. Takes about an hour and a half to go down. I would not mind trying Trimix but if there was any aching then the quality of the sex would not be good.

Tamu
Diagnosed 7/6/06, 1 of 10 core samples, 40%,Stage T1c, Gleason 3+3
Da Vinci on 11/01/06, Catheter out on 11/13/06
56 Years Old
Post Op Path, Gleason 3+3, Approx. 5% of prostate involved
Prostate Confined, margins clear
Undetectable PSA on 12/18/06, 6/25/07, 1/8/08
No more pads as of 1/13/07
Began injections in April '07
 


DanmanBob
Regular Member


Date Joined Feb 2008
Total Posts : 467
   Posted 4/18/2008 12:16 PM (GMT -6)   
Latest update....after some consultation via phone and fax (I am on vacation, returning today), my urologist agreed to the 30/1 bimix.  Franck's processed the order yesterday and sent it to me today, so I should receive it early next week.
 
Fingers crossed that it works for me without any significant side effects.  I already have mild Peyronie's (since age 33), so I will be looking closely for that symptom, of course.
 
I think....knock on wood....that I can make sure to avoid priapism by starting with a very low dose.  Of course, from reading posts here, it seems a low dose for some causes a multi-hour erection in others.
 
Any way, I am very excited and hope things work out ok....if not at first, then after trying a few different dosages to see what works best for me.
 
Thanks to all of you for your advice and support.
 
DanMan
Danman Bob
Age 57
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14
Biopsy result - 9 of 12 sticks showed cancer
Despite high Gleason score, cancer was confined to the prostate
Possible post-surgery radiation therapy...decision likely in late April 2008, depending upon PSA at that time
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of March 2008)
Began using Viagra 3 times a week December 2007 to stimulate blood flow
Began using Osbon Erec-Aid Esteem manual pump for therapy mid-February 2008
Will probably begin using bimix injections in addition to Viagra and pump in May 2008


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1464
   Posted 4/18/2008 12:27 PM (GMT -6)   
Hey Danman,

You are on the right track. We are all different and have to experiment to find the right dose. I think that docs have not had personal experience with these drugs and sometimes don't realize they don't work like an anti-biotic.

Good luck...

Jim
Age 73. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + 1000 mg L-Arginine + .03 cc Trimix = Excellent Results
PSAs from  1/3/07 - 1/17/08 0.00. 
Next PSA test on 7/17/08
"Patience is essential, attitude is everything."
 
 

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