Triple Androgen Blockade Therapy

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taiping
Regular Member


Date Joined Apr 2008
Total Posts : 62
   Posted 4/22/2008 9:34 PM (GMT -7)   
I would be glad to hear from anyone who has tried Triple Androgen Blockade Therapy (TAB) followed by finasteride maintenance (FM), as described in this 2005 ASCO abstract.
http://www.asco.org/portal/site/ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/?vgnextoid=76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=abst_detail_view&confid=37&index=y&abstractid=20271

I have been on TAB for PC for the last 9-months, under the guidance of Dr Steven Tucker who wrote the abstract with Dr. Bob Liebowitz.
My PSA has reduced from 19.2 to 0.057.
Night time urination has reduced from about 3 times a night to one time or less.
I have 3-monthly Zoladex shots, plus 150 mg/day Casodex and 0.5 mg/day Avodart (Dr. Liebowitz prefers Proscar).
Actually, I use generic Calutide (= Casodex) and Dutas (= Avodart) which are much cheaper.
Negative effects are (a) I have a muzzy head from the Casodex (b) for the first 3-months felt generally unwell (c) no erections, as to be expected (d) somewhat enlarged breasts.
I have not had significant hot flashes, but I live in a hot climate so it's difficult to tell.
My Gleason score was 3+3 = 6. DRE negative. Clinical stage T1c. Considered clinically localized PC. No symptoms. Age 61.

Regards,
Steve
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Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 4/23/2008 11:36 PM (GMT -7)   
Hi Steve,
I know some who were on this here. I'm bumping this back up to hopefully get the response you were hoping for. Stay tuned.

Tony
Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (1/08): <0.1
I will continue HT until May '09. 
Years in Remission (3/23/07): 1
Visit my Journey at:
 
STAY POSITIVE!
 
Prostate Cancer Forum Moderator


taiping
Regular Member


Date Joined Apr 2008
Total Posts : 62
   Posted 4/26/2008 7:16 PM (GMT -7)   

Thanks Tony for your input. I'm interested to hear about other folks who've tried Intermittent Triple Androgen Blockade Therapy as a first line of attack, without other radical treatments like RP, RT, or Chemo.

Intermittent TAB is usually applied for 12~13 months using ZOLADEX, CASODEX, and PROSCAR (or AVODART), and continuining with PROSCAR (or AVODART) after this period as "maintenance."

Steve

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