Lupron and alcohol

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New Member

Date Joined Mar 2008
Total Posts : 5
   Posted 4/27/2008 12:31 AM (GMT -6)   
I'm hoping someone here can give me some advice. I posted a while back about my brother who has prostate cancer, and that the Lupron seemed to be driving him mad. He was sober then but last week started drinking again. I think part of the problem is the Lupron caused severe depression. Already the combo of Lupron and alcohol is REALLY intense. He's hallucinating. I'm going to try to talk to his doctor on Monday, but I'm wondering if anyone here has had any experience of Lupron mixed with alcohol. He has had severe problems with alcohol in the past, so his liver has been compromised. Is the Lupron making it worse?

Regular Member

Date Joined Apr 2008
Total Posts : 62
   Posted 4/27/2008 2:29 AM (GMT -6)   
I found this at . . .

What should I avoid while using Lupron?

There are no restrictions on food, beverages, or activities while using Lupron. Follow any special instructions given by your doctor.
After insertion of the implantable form of leuprolide (Viadur), keep the site clean and dry for 24 hours. Do not bathe or swim for 24 hours. Avoid heavy lifting and physical activity for 48 hours and avoid bumping the site for a few days. After the cut has healed, normal activity can be resumed.



Regular Member

Date Joined Apr 2008
Total Posts : 65
   Posted 4/27/2008 7:27 AM (GMT -6)   

Hi goodsister,

My husband started Lupron last month and specifically asked the doctor if it was okay to drink beer. The doctor said that it does not affect the treatment and that drinking beer is fine. I do know that one of the side-effects of the Lupron is depression and maybe your brother's drinking is a form of self-treatment for the depression. Did he have other treatments before the Lupron? Maybe his frustrations and fears are coming through with his drinking.

I will keep you and your brother in my prayers.


Karen--New York
Husbands Info:
Age of diagnosis--62
2/28/08--PSA 279   DRE--positive/rock hard
Flomax and Casadex started
Biopsy--3/7/08--187cc--Gleason 10--12 of 12 positive--Perineural and LV invasion identified
T4 bone met.--hydroureteronephrosis/right kidney
3/28/08--Lupron Inj. started
4/7/08--Zometa IV started

Regular Member

Date Joined Apr 2008
Total Posts : 62
   Posted 4/27/2008 8:47 AM (GMT -6)   

I should have mentioned that with the ZOLADEX shots I'm taking, similar treatment to Lupron, I've limited my alcohol consumption to one or two large beers, because I started to feel unwell if I drank more. However, it was not anything like hallucinating.

Good idea to talk to the doc about it. My doc insists on Liver Function Tests to make sure the hormone therapy (ZOLADEX, CASODEX, AVODART) is not causing liver damage. NO problem detected in 9-months.



Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 4/27/2008 9:22 AM (GMT -6)   
A major side effect of cancer, Lupron or no Lupron, is depression. That alone can cause one to "drown" themselves. It wanted to at first, but i am able to cope with this disease. Your brother needs a clear head to fight this disease. And starting with the doctor is a good thing. Stay with him, and try to help him back to a positive way of life...And I know about the alcoholism, had a member or two in my family, and if they don't want help, they wont accept any.

Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (1/08): <0.1
I will continue HT until May '09. 
Years in Remission (3/23/07): 1
Visit my Journey at:
Prostate Cancer Forum Moderator

New Member

Date Joined Mar 2008
Total Posts : 5
   Posted 4/27/2008 4:48 PM (GMT -6)   
Thank you all. You've reminded me that the Lupron might be damaging his already damaged liver, and that's why the alcohol is affecting him so dramatically. I hope that I can talk to his doctor tomorrow.
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