I have not been on Lupron as long as you but I will offer my experience thus far. I have had one shot in May 2008 and a second due in September. I will be taking the Lupron for two years total. I am in the middle of IMRT/IGRT treatments.
I still think about sex but the equipment does not respond. It gives it a try but not enough to do anything with. I am single so it has not been much of an issue.
Hot flashes. Usually after a meal and from around midnight to 5:00 am I get one every hour. A cup of coffee will trigger one as well. If sit or lie down in the late afternoon they seem to come on. I have learned that if I stand up and move about a little they seem to go away quicker. Some have been pretty intense. Similar to eating a hot pepper!
I have gained weight in spite of continuing to work out and run three times a week. I must confess that my running has gotten slower and less frequent than when I started my treatment. I think it is more the radiation than the hormoes though.
I can think of no other side effects that I would attribute to the hormones at this point. I am looking forward to the last one even though it is two years away.
One more note. Just prior to beginning my radiation and 8 weeks after the Lupron and 30 days of Casodex I tested my PSA and the reading was .82 vs 21.5 at diagnosis. I really do not know what the significance of that is other than it shows that the PCa has responded to the hormone. So, the drugs do have some effect.
Good luck to you Dale and to your family as well.
PSA 21.5 (first and only test resulted from follow up visit to emergency room for kidney stone. first time for kidney stone too)
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear
Chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.