PSA Dramatic Jump

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el paso rudy
New Member

Date Joined Apr 2008
Total Posts : 8
   Posted 5/3/2008 7:29 PM (GMT -6)   
Hey, it's been awhile since I've been on the board ... My brother-in-law says his PSA jumped from 1 to 13 in six months. Doctor did a re-test two days later, and the result was 52. Sounds like a lab error. Anyone hear or know of a similar experience. He is scheduled to have biopsy in the middle of May. I encouraged him to push doctor to hae it done as soon as possible. A 52, if real, would be a sign of advance prostate cancer. - El Paso Rudy

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 5/3/2008 7:54 PM (GMT -6)   
Hi Rudy,
Were you here under another screen name? It might be possible you were a member of another board?

Any way. I agree with your assessment. That is an extremely fast jump and I would not wait to biopsy. But that stated two weeks is pretty quick. Some would say to wait and see if this is infection, but that is a very fast rise. And it's too high to assume it is.

Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (1/08): <0.1
I will continue HT until May '09. 
Years in Remission (3/23/07): 1
Visit my Journey at:
Prostate Cancer Forum Moderator

Regular Member

Date Joined Feb 2008
Total Posts : 467
   Posted 5/3/2008 10:03 PM (GMT -6)   

Mine jumped from 1.8 to 9 in about a year, then to 14 three and one-half weeks later.  I had a biopsy done the day after the 14 results came in.  No way I was going to wait.

My urologist had a patient go from 0.4 to 30 in six months.

Danman Bob, Born 1951
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14; Biopsy result - 9 of 12 sticks showed cancer
Post-op pathology stated that cancer was confined to the prostate
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of late April 2008)
100 MG Viagra 3 times a week beginning December 2007
Osbon Erec-Aid Esteem manual pump for therapy beginning mid-February 2008
30 MG papaverine/1 MG phentolamine bimix injections beginning late April 2008
Five week post-op PSA 0.2, five month post-op PSA 0.1, next test August 2008

Veteran Member

Date Joined Apr 2008
Total Posts : 1382
   Posted 5/4/2008 9:50 AM (GMT -6)   
I to would not wait either, I had my biopsy done the day after my psa results came in and I am glad I did, granted once you know you have to deal with it, but not knowing can be worse. We are all hopeful that this could be an error or an infection, but in the event it is real, know our prayers and thoughts are with you, and thru a positive attitude many things are possible. Life is opening a new chapter, neither good nor bad in the begining, but in the end together we will make it good. Stick with us here on healing well and let us know how things go.

peace to you
My PSA at diagnosis was 16.3
age 46 (current)
My gleason score from prostate was 4+5=9 and from the lymph nodes was 4+4=8
I had 44 IMRT's
Currently on Lupron
I go to The Cancer Treatment Center of America
Married with two kids

Regular Member

Date Joined Feb 2008
Total Posts : 42
   Posted 5/4/2008 6:37 PM (GMT -6)   
My psa was 4ish, MRI was negative. Did biopsy just to rule out PCa since no symptoms and no family history;but I am glad I did. Ask your brother in law to get the biopsy done as a matter of urgency.
Dx Age 48 Nov 07
Psa 4.5, Biopsy 2/8 cores positive Gleason 3+3
No perineural or lymphovascular invasion in the biopsy specimen. Rushed to Robotic surgery Jan 08

Geason 3+3 ,10% both lobes, There is perineurial invasion
No extraprostatic spread seen , Seminal vesicles normal,Nerves spared
Cancer close to apex but margins clear T2c NXMX
Incontinence bad but in April 08- suddenly down to 1 pad
ED - started cialis once every 2 or 3 days from April but no improvement
1st post op Psa <.1 (May 08)

Regular Member

Date Joined Mar 2008
Total Posts : 66
   Posted 5/6/2008 6:23 AM (GMT -6)   
My Uncle's jumped from 2 to 8 in about 18 months. His journey is in my signature. The sooner the better for a biopsy. I felt we had to wait so long.
Father diagnosed 13 years ago @ age 63
Watchful waiting until PSA jumped from 6 to 10
Cancer found in 1 core
Gleason score 6
Seeds implanted
PSA has been low since (don't know exact numbers)
Uncle (mother's brother) age 68
PSA jump from 2 to 8 in 18 months (2/08)
DRE was normal (2/08)
Biopsy (3/08) Cancer found
Bone scan (clear) 
Fine Needle Lymph Biopsy (Positive)
Gleason Score
(2) 4 + 3
(1) 3 + 3
(4) 4 + 3
7 of 12 cores positive
Waiting for MRI and another CAT Scan before radiation
Started Casodex and Eligard

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