Need info. on low testosterone and my PCa.

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ChrisR
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Date Joined Apr 2008
Total Posts : 814
   Posted 5/12/2008 3:00 PM (GMT -6)   
I have just been Dx with a PSA of 2.75 and Gleason 3+3=6.  I also have low testosterone of 157.  I am finding very troubling info. about this combination and my PCa might be much more aggressive then my number indicate.  I had a 52 point biopsy with 4 cores coming back at 2% to 5% involvment.  I have read there is a 40% chance of positive margins with this condition.
 
Does anyone have any knowledge about this....
 
Thanks

livinadream
Veteran Member


Date Joined Apr 2008
Total Posts : 1382
   Posted 5/12/2008 3:07 PM (GMT -6)   
Not sure I understand the question. I will tell you that my doctors told me that I had to keep my testosterone under 50 or they would put me back on Casodex. Keep in mind my cancer has spread. With a mid range gleason score like yours the target number might be higher. I am going to watch this thread to see what others comment.
Thanks for writing ChrisR and stay positive and keep the faith.

peace and love
Dale
My PSA at diagnosis was 16.3
age 46 (current)
My gleason score from prostate was 4+5=9 and from the lymph nodes was 4+4=8
I had 44 IMRT's
Casodex
Currently on Lupron
I go to The Cancer Treatment Center of America
Married with two kids
 


ChrisR
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Date Joined Apr 2008
Total Posts : 814
   Posted 5/12/2008 3:08 PM (GMT -6)   

biker90
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Date Joined Nov 2006
Total Posts : 1464
   Posted 5/12/2008 4:28 PM (GMT -6)   
Hey Chris,

I had low T for 10 or so years before PCa and was on TRT with shots. My first uro/sugeon took me off the shots before surgery and would not let me resume afterward. Over the next 3 months my T level fell to 48 and I had all the symptoms of low T again. (The whole story is in my thread whose link is in my signature.) Currently I am back on TRT and feeling great.

It seems there is disagreement in the medical world about whether T causes PCa to grow on not. (As your link shows) Luckily, I found a urologist that was not adamantly against TRT after PCa as my first uro was.

Just goes to show we have to take charge of our own recovery. Without this forum and the help of Pete and Swimom I would never have found a solution and would probably be dead.

Jim


Age 73. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + 1000 mg L-Arginine + .03 cc Trimix = Excellent Results
PSAs from  1/3/07 - 1/17/08 0.00. 
Next PSA test on 7/17/08
"Patience is essential, attitude is everything."


DanmanBob
Regular Member


Date Joined Feb 2008
Total Posts : 467
   Posted 5/12/2008 4:49 PM (GMT -6)   

Chris, why such a high probability of positive margins in your case?

Have you checked the Partin tables, which will give you the percentage chance of cancer outside the prostate, based upon statistical findings and your psa, gleason score, clinical stage from biopsy?  If not, give that a shot.

DanMan


Danman Bob, Born 1951
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14; Biopsy result - 9 of 12 sticks showed cancer
Post-op pathology stated that cancer was confined to the prostate
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of late April 2008)
100 MG Viagra 3 times a week beginning December 2007
Osbon Erec-Aid Esteem manual pump for therapy beginning mid-February 2008
30 MG papaverine/1 MG phentolamine bimix injections beginning late April 2008
Five week post-op PSA 0.2, five month post-op PSA 0.1, next test August 2008


ChrisR
Veteran Member


Date Joined Apr 2008
Total Posts : 814
   Posted 5/12/2008 4:55 PM (GMT -6)   

I found another study that said people with low T had a 40% chance of PSM after RP. 

I did not know their gleason scores either.

Another strange thing is that the Dr. that Dx me has insisted on me coming back for a follow-up

meeting and insists I bring a family member, even though I said I would not be treated by him.

I don't know what he is up to.  I will find out on Wed. this week.

 


DanmanBob
Regular Member


Date Joined Feb 2008
Total Posts : 467
   Posted 5/12/2008 5:25 PM (GMT -6)   
Chris,
 
I have low testosterone...took meds for it until I found out I had PCa....then stopped immediately.
 
I also had a gleason 9, psa 14....and fortunately no positive margins.
 
Until your post, I had never heard of a connection between low testosterone and positive margins.  Who is the source of that article, if I may ask?
 
Good luck.
Danman Bob, Born 1951
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14; Biopsy result - 9 of 12 sticks showed cancer
Post-op pathology stated that cancer was confined to the prostate
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of late April 2008)
100 MG Viagra 3 times a week beginning December 2007
Osbon Erec-Aid Esteem manual pump for therapy beginning mid-February 2008
30 MG papaverine/1 MG phentolamine bimix injections beginning late April 2008
Five week post-op PSA 0.2, five month post-op PSA 0.1, next test August 2008


ChrisR
Veteran Member


Date Joined Apr 2008
Total Posts : 814
   Posted 5/12/2008 5:28 PM (GMT -6)   

I found it on the web.   Google  low testosterone and prostate cancer. You will

find some things.

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