Does sex affects PSA result?

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KrisP
Regular Member


Date Joined Mar 2008
Total Posts : 162
   Posted 5/16/2008 2:28 PM (GMT -6)   
 Pardon me if this has been discussed earlier (I checked but didn't find any post relating to this). I was wondering that since the body absorbed the sperm after sex, if that would affect a PSA result. Would not want to do anything that will affect my coming PSA.

 

Kris
Biopsy done 3/2008
Pathology report: Gleason 6 (3+3), involving left lobe
DRE=15gm with indurated left base and mid prostate
Cores positive: left base medial, left base lateral, left mid medial and left mid lateral (4 of 12)
Clinical stage t2b.
Prostate Carcinorna 185
DaVinci Surgery on 4/21/2008 in Austin by Dr Randy Fagin.
Pathologist report upgraded to a Gleason 7 (3+4)
Clinical stage upgraded also to a T3a
Margins Clear


Lungman
Regular Member


Date Joined Jan 2008
Total Posts : 276
   Posted 5/16/2008 2:54 PM (GMT -6)   
PSA (prostate-specific antigen) is only produced by prostate cells, so if all of your prostate cells are gone, your PSA should theoretically drop to 0. Ideally all of the cells, malignant and normal, were removed with surgery. You should only have a detectable PSA if you have prostate cells remaining in your body. Sperm will not produce PSA.
46 you when diagnosed, now 47
Pre-Op PSA 9.9
1 of 12 cores positive, Gleason 3+3
DaVinci on 9/5/2007
Post-Op Gleason 3+6, Negative Nodes and Margins
Less than 1% of prostate involved with CA
3 Month PSA 0.01, 6 Month PSA 0.01
Incontinence resolved 9/15/2007, one day after cath removal
ED showing significant improvement, more notable over last month
with Viagra 100 mg.
Success with BiMix


KrisP
Regular Member


Date Joined Mar 2008
Total Posts : 162
   Posted 5/16/2008 4:11 PM (GMT -6)   
Hi Lungman
Thanks for your input. Guess I'm kind of confuse as to why some people who had surgery to remove the prostate with negative margins and still get a rise in PSA after a few months.
For someone who has negative margins per post surgery pathologist report, is it correct to say that the only way to have a detectable PSA is if the cancer had spread prior to the surgery?
 
Kris
 
Biopsy done 3/2008
Pathology report: Gleason 6 (3+3), involving left lobe
DRE=15gm with indurated left base and mid prostate
Cores positive: left base medial, left base lateral, left mid medial and left mid lateral (4 of 12)
Clinical stage t2b.
Prostate Carcinorna 185
DaVinci Surgery on 4/21/2008 in Austin by Dr Randy Fagin.
Pathologist report upgraded to a Gleason 7 (3+4)
Clinical stage upgraded also to a T3a
Margins Clear


DanmanBob
Regular Member


Date Joined Feb 2008
Total Posts : 467
   Posted 5/16/2008 4:32 PM (GMT -6)   

Kris,

Three possibilities that I know of...

1) Pathology report could be wrong

2) Some cancer cells outside the tissue examined could remain (not likely if margins were deemed negative)

3) Cancer returns later, which it does in a significant percentage of cases where the Gleason score was very high.  That is why, despite a good pathology report, I am likely to have radiation later this year.


Danman Bob, Born 1951
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14; Biopsy result - 9 of 12 sticks showed cancer
Post-op pathology stated that cancer was confined to the prostate
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of late April 2008)
100 MG Viagra 3 times a week beginning December 2007
Osbon Erec-Aid Esteem manual pump for therapy beginning mid-February 2008
30 MG papaverine/1 MG phentolamine bimix injections beginning late April 2008
Five week post-op PSA 0.2, five month post-op PSA 0.1, next test August 2008


positivelife
Regular Member


Date Joined Feb 2008
Total Posts : 42
   Posted 5/16/2008 4:57 PM (GMT -6)   
Hi Kris
I read somewhere in forum that sex nearer to a psa test (24 hrs) may affect psa results. But that is if you have a prostate, so not relevant if the whole prostate is removed during surgery.

If someone who has negative margins per post surgery pathologist report, I suppose if there is a psa rise it means that the cancer had spread prior to or during surgery ( microscopic spread). Sometimes a minuscule of a spread may result in a psa rise only after many months/years? after surgery. That's why we all worry just before a psa test.

I do have a question. If sperm and testosterone does not affect psa test why do people who has a detectable psa (spread) after surgery, given Hormone Therapy ( to reduce testosterone/production of sperm )?
Dx Age 48 Nov 07
PRE OP
Psa 4.5, Biopsy 2/8 cores positive Gleason 3+3
No perineural or lymphovascular invasion in the biopsy specimen.
Rushed to RRP without much research- Jan 08

POST OP
Geason 3+3 ,10% both lobes, There is perineurial invasion
No extraprostatic spread seen , Seminal vesicles normal,Nerves spared
Cancer close to apex but margins clear T2c NXMX
Incontinence pretty bad until April 08- suddenly down to 1 pad
ED - started cialis once every 2 or 3 days from April but no improvement
1st post op Psa <.1 (May 08)


Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 5/16/2008 5:04 PM (GMT -6)   
Cancer cells can escape the prostate before or during surgery. As DanamanBob said, this is more likely if the Gleason score is high. Or there may be some normal prostate cells left behind still attached to your plumbing.
 
They can then lie dormant for many years before before they start multiplying and producing detectable amounts of PSA. This is why PSA tests will be part of our lives for at least the next ten years.
 
Hormone therapy, as I understand it, does not kill the cancer cells -- it just slows down the multiplication.


Age 63. Other than cancer, in good health; BMI 20
Pre-op: No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4 of 12 cores
7 March 2008, RRP, non nerve sparing
Two nights in hospital; catheter and staples out after 7 days
Continent, no pads needed from the get-go
Post Op: Stage pT2 M- N-; clear margins and lymph nodes; Gleason 4+4=8; prostate weight: 37gm
6-week PSA: 0
No erections (of course!)
Experimenting with VED and Bimix
 

Post Edited (Piano) : 5/16/2008 4:10:20 PM (GMT-6)

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