I am certainly no expert here, but from what I have read, seen in the Han Tables and so on......higher Gleason scores mean a higher probability of return of cancer, even if margins were deemed clean/negative.
My urologist told me a month ago that even though my PSA is considered undetectable with the measuring means used by his office, he is probably going to suggest radiation later this year....because my post-op Gleason is a 9. Even if it was an 8, he would do likewise.
Hopefully others will have more concrete information to share.
Danman Bob, Born 1951
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14; Biopsy result - 9 of 12 sticks showed cancer
Post-op pathology stated that cancer was confined to the prostate
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of late April 2008)
100 MG Viagra 3 times a week beginning December 2007
Osbon Erec-Aid Esteem manual pump for therapy beginning mid-February 2008
30 MG papaverine/1 MG phentolamine bimix injections beginning late April 2008
Five week post-op PSA 0.2, five month post-op PSA 0.1, next test August 2008