Anyone ever hear of anything like this? 12 years of rising PSA, 7 negative biopsies, psa now 16+

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PianoMan
Regular Member


Date Joined Feb 2007
Total Posts : 365
   Posted 6/10/2008 10:34 AM (GMT -6)   

I recently hooked up with an old friend from years back (now age 60) who told me that since 1996, when his first PSA test came back at 6, he has had seven biopsies – all negative.  The last biopsy was a week ago (again negative) and he’s now walking around with a PSA of over 16.  He’s never had a symptom.  One thing he did say (upon my asking him) was that no doctor over the years has ever put him on a course of antibiotics for 10 days or so before administering a second PSA test to rule out infection as the cause of the rise.  But could someone have prostatitis for 12 years?

I think I once read somewhere that there are glands/organs other than the prostate that can produce PSA in the blood?  Could this be what’s happening to this guy?

Any thoughts?  I’ve never heard of anything like this.  The docs said they want to see him again in six months.
Thanks!
Tom

D.O.B - 8/9/52

PSA: First ever was 9.8 in late Oct. ‘06, two weeks later, 10.1

DRE: Negative

Biopsy results 11/22/06.  Both lobes involved.  Six out of eight cores positive - from 100 percent to 90, to 60, to 50, two 20s and two zeros.

Gleason 3+3 = 6

Da Vinci Robotic RP surgery, City of Hope, Jan 12, 2007

Post surgery pathology – Organ confined, Gleason still 6, margins clear.  Volume of tumor much less than biopsy suggested.  12 percent overall.

First post-surgery PSA -- Undetectable, 2/20/07

Second post-surgery PSA -- Undetectable, 9/11/07

Third post-surgery PSA -- Undetactable, 2/15/08

Surgery for bilateral inguinal hernia repair, 4/4/08 


Pelahatchie
Regular Member


Date Joined Jul 2007
Total Posts : 86
   Posted 6/10/2008 10:50 AM (GMT -6)   
I know a guy that had a similar experience over several years and his PSA actually reached 20 before a biospy finally discovered cancer and his prostate was removed.  I believe he is doing well.
Age 45 at DX
 
DX 8/05 Gleason 5, Mayo clinic Second Opinion Gleason 6, PSA 2.8
 
Da Vinci surgery Dr. Dasari, Centennial Nashville 9/24/05
 
Pathology Report Gleason 6, 15 % on left side only very near to the edge of capsule, too close to call on margins, doc's said to watch it very closely, final decision T2A
 
PSA's have basically ranged from <.04 to .05 for two years.
 
no E.D. and no Incontinence, feel very blessed
 
PSA Nov 07 = .06
 
PSA Dec 10th 07 =.07
 
PSA Jan 4th 2008= .1
 
Started Guided IMRT on January 7th, 2008 to treat prostate bed and lymph nodes, completed on March 6th, 2008
 
PSA April 18th 2008 =.03


Doting Daughter
Veteran Member


Date Joined Aug 2007
Total Posts : 1064
   Posted 6/10/2008 11:24 AM (GMT -6)   
I know someone who had three negative biopsies before discovering his cancer. However, his PSA was not that high, but it was rising. Did you ask him how many samples were taken during the biopsies? Sometimes if the cancer is very small, it is easy to miss the area in a biopsy. Hopefully, his doctor would have looked at his history and done more tissue samples.
I will hope that it is Prostatitis. I don't think he could have Prostatitis for ten years, but I know that it does return. Keep us posted and he is lucky to have you as a friend!!
Father's Age 62 (now 63)
Original Gleason 3+4=7, Post-Op Gleason- 4+3=7,
DaVinci Surgery Aug 31, 2007
Focally Positive Right Margin, One positive node. T3a N1 M0.
Bone Scan/CT Negative (Sept. 10, 2007)
Oct. 17 PSA 0.07
Nov. 13 PSA 0.05
Casodex adm. Nov 07, Lupron beg. Dec 03, 2007 2 yrs
Radiation March 03-April 22, 2008- 8 weeks 5x a week
Praying for a cured dad. First PSA 3 months!


Co-Moderator Prostate Cancer Forum


smilingoldcoot
Regular Member


Date Joined Jan 2008
Total Posts : 338
   Posted 6/10/2008 11:34 AM (GMT -6)   

I had prostatitis several times over a 11 year period and had no symptoms.  The only reason to check was that my PSA was elevated.  It was only diagnosed by doing a lab test on semen.  I can think that it might be possible to have it for a long period of time but I ain't no doctor.

I think I would be seeking a second opinion if not already done.

Richard yeah   tongue   yeah


Retired USAF Richard & Debbie on The Shores of Toledo Bend Lake Louisiana
Biospy 1/10/08 Gleason 10, Stage T1C  8 of 12 samples positive all Less Than 5% 
U of Florida Proton Therapy Institute
5/2/2008 LUPRON & Casodex
IMRT to start 5/16/2008 for approx 4 weeks with Proton to follow for approx 4 weeks
Turn Stumbling Blocks into Steping Stones and Keep Smiling
Our Journey is on WWW.GLEASON10.COM
 


anniea
Regular Member


Date Joined May 2007
Total Posts : 234
   Posted 6/10/2008 11:06 PM (GMT -6)   

Hi Pianoman,

Ricks Dr. once told us that PSA is also produced by the adrenal glands.

 

Best Wishes to you and your friend

Diana


Rick & Diana
Age 68/ 67@ Dx
6-30-06  PSA 2.54
1-22-07  PSA 4.98
1-26-07  PSA 5.09
Diag: 2-14-07 Gleason 8 Stage T1c PSA 5.09
Bone Scan 3-1-07 Clear
3-6-07 Triple Spinal Fusion (due to old back injury)
Radical retropubic surgery 4-2-07  Post surgery Gleason 9 Stage T3a Positive margins
4-29-07 PSA 0.02
6-9-07   PSA 0.02
7-6-07   PSA 0.03
8-1-07   CT Scan & Chest X-Ray   Clean
 9-26-2007 PSA 0.07
11/1/07 PSA 0.1
11/30/07 PSA 0.12
01/31/2008 PSA 0.3
03/01/2008 PSA 0.3
04/28/08 PSA 0.6


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 6/10/2008 11:40 PM (GMT -6)   
Interesting sometimes how things flow at this site then you see what others talk about in experiences.

A customer of mine is 61. His PSA has been above 6 for ten years. Fluctuates and was even recently in double digits. He just did another PSA and is awaiting the results. His first biopsy was negative. He has declined additional ones but might be headed that way again. Small world of discussion. He will hear more in the coming days if he will biopsy again.

Tom you also mention other glands that produce PSA. This is correct information though I'm not sure exactly what the affect on PSA is. Diana mentions adrenal glands that this may be a source. Adrenal glands do produce high amounts of DHT (dihydrotestosterone) that is easily converted to testosterone by PCa cells. This is why while on HT we will usually take Casodex, a GNRH, blocker that suppresses androgens sourced from the adrenal glands, to go along with Lupron, a clinical castration drug.

It is possible that he produces a significantly larger amount of DHT in the adrenals that cause higher PSA readings. It i salso possible that his PCa has missed the needles. At some point, a more detailed biopsy should be done.

I sure wish I could go back to the days where I knew nothing about this stupid disease.! eyes

Tony


Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 9 '08): <0.1
I will continue HT until May '09. 
Years in Remission (3/23/07): 1
Visit my Journey at:
And at:
 
STAY POSITIVE!
 
Prostate Cancer Forum Moderator


PianoMan
Regular Member


Date Joined Feb 2007
Total Posts : 365
   Posted 6/11/2008 7:00 PM (GMT -6)   
Thanks to all of you for your responses.  I'll pass them along and hope they shed some light on what's going on with this guy.
Tom

D.O.B - 8/9/52

PSA: First ever was 9.8 in late Oct. ‘06, two weeks later, 10.1

DRE: Negative

Biopsy results 11/22/06.  Both lobes involved.  Six out of eight cores positive - from 100 percent to 90, to 60, to 50, two 20s and two zeros.

Gleason 3+3 = 6

Da Vinci Robotic RP surgery, City of Hope, Jan 12, 2007

Post surgery pathology – Organ confined, Gleason still 6, margins clear.  Volume of tumor much less than biopsy suggested.  12 percent overall.

First post-surgery PSA -- Undetectable, 2/20/07

Second post-surgery PSA -- Undetectable, 9/11/07

Third post-surgery PSA -- Undetactable, 2/15/08

Surgery for bilateral inguinal hernia repair, 4/4/08 

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