Prostate Cancer and Lifestyle Changes

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Tim G
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Date Joined Jul 2006
Total Posts : 2286
   Posted 6/17/2008 5:32 PM (GMT -6)   
Here's an article from a Daily Medical News service I subscribe to about change in lifestyle and its effect on prostate cancer. 
 
 

Study suggests lifestyle changes may alter genes in men with early stage prostate cancer.

Reuters (6/17, Dunham) reports, "Comprehensive lifestyle changes, including a better diet and more exercise can lead,...to swift and dramatic changes at the genetic level," according to a study published in the Proceedings of the National Academy of Sciences. Researchers followed "30 men with low-risk prostate cancer who decided against conventional medical treatment such as surgery and radiation, or hormone therapy." The patients had "three months of major lifestyle changes, including eating a diet rich in fruits, vegetables, whole grains, legumes, and soy products, moderate exercise such as walking for half an hour a day, and an hour of daily stress management methods such as meditation."

        According to U.S. News & World Report (6/16, Healy), "Associated changes in gene behavior after three months of the intervention program were based on analyzing normal prostate tissue from the before-treatment and after-treatment biopsies for levels of RNA, the molecules that translate the DNA blueprints into action." The researchers found that "[e]xpression was beneficially changed in over 500 different genes."

        The U.K.'s Telegraph (6/17, Highfield) notes that overall, about "50 disease preventing genes were upregulated, or turned on, and certain disease-promoting genes, including genes involved in prostate cancer and breast cancer, were downregulated, or turned off." This research was conducted by "Dr. Dean Ornish, founder and president of the non-profit Preventive Medicine Research Institute and clinical professor of medicine at the University of California, San Francisco." He was "[i]nspired by studies that show prostate cancer is rarer in parts of the world where people eat a predominantly low-fat plant-based diet, [and] he devised a vegan diet for patients, along with exercise." Results of this study "complement earlier work that showed that, after a year, PSA levels (a protein linked with prostate cancer) decreased in men in the group who made comprehensive lifestyle changes but increased in the comparison group."

        WebMD (6/16, DeNoon) quoted Dr. Ornish as saying, "People say, 'Oh, it is all in my genes, what can I do?' That's what I call genetic nihilism." He added that the diet followed in this study "may be an antidote to that," and "[g]enes may be our predisposition, but they are not our fate."


Johnny Canuck
Regular Member


Date Joined Jan 2008
Total Posts : 88
   Posted 6/18/2008 8:51 AM (GMT -6)   
I wonder though...
"Associated changes in gene behavior after three months of the intervention program were based on analyzing normal prostate tissue from the before-treatment and after-treatment biopsies for levels of RNA, the molecules that translate the DNA blueprints into action."
 
That speaks to potential, and to preventative strategies. I reduced my PSA using complementary medicine, but that could also just be a matter of reducing the inflammation.
 
Am I mistaken, or is the report missing data on the reaction of cancerous tissue to the diet changes? Is that covered by the actions of healthy cells staying healthy? And what percentage...all of them? I'd be wondering what the cancer looks like, as well.
 
Anyway, it's nice to know we're not forgotten...
Age: 54
Gleason Score: 3+3=6
PSA: 3.33
Biopsy:7/8 Positive
Stage: "Bulky" T1c
Prostate Size: 27cc
 
Diagnosed: December 05, 2007
Brachytherapy: February 26, 2008
68 seeds, (Iodine 125). 
 
Walk my path at:
 
 


ChrisR
Veteran Member


Date Joined Apr 2008
Total Posts : 814
   Posted 6/18/2008 11:38 AM (GMT -6)   

The problem with diet is nobody can directly tie it to a reversal or cure of a diesease.  There is a lot of good evidence that diet plays a big part in healing illness.  Even cancer.  I have a friend that was diagnosed with advanced breast cancer.  She was 30 at the time, given 6 months.  The cancer had already mets to her liver.  She went on a strick organic diet.  She is now 35.  She did do chemo and had the cancer removed.  The mets to her liver are now gone and the Dr. can't figure out why her cancer is gone.  She believes it is her diet. 

You are what you eat.....


GBINAB
Regular Member


Date Joined Apr 2008
Total Posts : 203
   Posted 6/18/2008 2:23 PM (GMT -6)   
I have read some article to that effect as well , never tried it before my open RR, i also heard or actually read of someone that took a hot pepper supplements and claims his cancer was not detectable any longer after 6 weeks!!!

A friend of mine have tried to convince me to try that HEALTHY DIET method before letting a surgeon into my body, i just did not feel completely convinced about the results, however i am sure there is some direct correlation between the 2... i elected to get mine out , BUT i do believe that my PSA that was .1 6 months post op is now at 0.0 at a year post op and i must relate it to my change of life style (eating healthier , exercise more , etc) as well as my ED progress ....there is no doubt that our body is like an engine , an if we put bad fuel in it , then it would not run smoothly, and vice versa, the only question left is to what extend it can change what is already in our body ? and ca it reverse it completely ?


Good Luck to all

GB :-) :-)
April 2007 PSA 8.4 for last 6 months biopsy shows PC 3+3=6
June 13 2007 Nerve Sparing open RP / Dr. Christopher Johnson at St. Francis Hospital NY.
4 days later home for Fathers Day, and Catheter.
Removal of catheter 10 days later , incontinence not an issue, no pads used from the get go.
1 month PSA next to not detected

ED is a longer battle:
1 month out start using occasionally Cialis and 50MG Viagra to promote blood flow with no response.
3 months and 6 months PSA not detected
ED 6 months mark starting with VED therapy and being more aggressive with meds , in addition taking Folgard supplement daily.
April 2008 : 10 month out and start seeing some serious improvements with ED while using Meds and VED , can achieve erections, Mid nights erections almost on a regular basis , and uncontrolled 90 % erections spontaneously.
1 year visit on June 13 2008 woohoooo!!!

UPDATE 1 YAER FOLLOW UP
ED: With Viagra Usable erection for intercourse , AND AT 80% without any medications !! WoooHoooo!!!!
PSA results not in yet. Fully continent since removal of catheter.
PSA one year : 0.0 as of 6/13/ 2008 BIG Wooohoooooooooo!!!!


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1464
   Posted 6/18/2008 3:53 PM (GMT -6)   
The problem with anecdotal evidence is that only the successful get their say. The dead ones don't give any input. In my opinion, letting cancer grow in my body while I experiment with diet is a death wish. The mantra that PCa is slow growing and doesn't hurt anything is, in my opinion, playing russian roullette. I couldn't sleep at night wondering if it was the slow or fast spreading type and the only way to be sure is to get a post-op pathology report.

I recently wrote a note to my family doctor expressing my extreme gratitude for his diligence in discovering my prostate cancer and lung cancer in their early stages. I had surgery to fix the prostate cancer and have 18 months of zero PSAs to show for it. I will have surgery next week to fix the lung cancer and expect years of clean scans to show for that.

Got cancer? Get rid of it!!

Jim
Age 73. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + 1000 mg L-Arginine + .03 cc Trimix = Excellent Results
PSAs from  1/3/07 - 1/17/08 0.00. 
Next PSA test on 7/17/08
"Patience is essential, attitude is everything."


GBINAB
Regular Member


Date Joined Apr 2008
Total Posts : 203
   Posted 6/18/2008 4:58 PM (GMT -6)   
I concur with Biker90,
i hav done the same an FAST i wanted it out of my body as fast as i can ...the rest i would battle with ... and i do not regret it after one year out getting a 0.0 PSA last week ... Good luck with your lung operation Biker90 my prayers are with you and i am sure you will overcome it as well .....

GB :-) :-)
April 2007 PSA 8.4 for last 6 months biopsy shows PC 3+3=6
June 13 2007 Nerve Sparing open RP / Dr. Christopher Johnson at St. Francis Hospital NY.
4 days later home for Fathers Day, and Catheter.
Removal of catheter 10 days later , incontinence not an issue, no pads used from the get go.
1 month PSA next to not detected

ED is a longer battle:
1 month out start using occasionally Cialis and 50MG Viagra to promote blood flow with no response.
3 months and 6 months PSA not detected
ED 6 months mark starting with VED therapy and being more aggressive with meds , in addition taking Folgard supplement daily.
April 2008 : 10 month out and start seeing some serious improvements with ED while using Meds and VED , can achieve erections, Mid nights erections almost on a regular basis , and uncontrolled 90 % erections spontaneously.
1 year visit on June 13 2008 woohoooo!!!

UPDATE 1 YAER FOLLOW UP
ED: With Viagra Usable erection for intercourse , AND AT 80% without any medications !!
Fully continent since removal of catheter.
PSA one year : 0.0 as of 6/13/ 2008 BIG Wooohoooooooooo!!!!


pcdave
Regular Member


Date Joined Oct 2006
Total Posts : 444
   Posted 6/19/2008 10:45 PM (GMT -6)   
Dear Jim (biker 90)

Sorry to hear that you have to undergo more surgery to keep your lungs healthy. You are a real trooper, always with strong determination to conquer any and all of life's challenges that you have been confronted with. Best of luck and all good wishes for a speedy recovery.

Dave
-69 years young!
-29 core biopsy 9/27/06 at age 68
-PSA 7.1, Stage T1c, Gleason 7 (3+4) [less than 20% in one area], Gleason 6 [less than 5% in two other areas], Negative DRE, bone scan and Endorectal MRI. 
-Completed 39 Proton radiation treatments 2/22/07-4/18/07.   
-PSA History: 7.1 pre-treatment; post treatment: 2.1 (3 mo.), 2.4 (6 mo.), 1.7 (9 mo), 1.6 (12 mo.).  Radiation oncologist said: the 3-mo. drop of 70% exceeded expectations; the slight 6-mo. bump up was not a cause for concern now; expected drop in 12-18 mo. is 75%.
-The following is a link to My Journey With Prostate Cancer -- Proton RadiationTherapy.  
 
 


Tim G
Veteran Member


Date Joined Jul 2006
Total Posts : 2286
   Posted 6/20/2008 12:03 AM (GMT -6)   
Selmer said...
However, from the response here much of the time, any suggestion that PCa and lifestyle are connected, seem to be given little value.
If I had two sons, I'd be much more focused on their lifestyle than on getting a PSA test at age 35.

I do understand the focus here, but not to the point of dismissing the value of lifestyle changes.

From reading I have done since being diagnosed, I think it is important to do both (1) Get tested early and (2) Make lifestyle changes that have been shown in numerous studies to prevent cancer, heart disease, etc.
 
I would not personally have relied on lifestyle changes alone to slow prostate cancer, but had it treated in its early stages and am slowly changing my dietary habits (I already get plenty of the right kinds of exericise) to prevent its recurrence. 

phillysub
Regular Member


Date Joined Nov 2007
Total Posts : 64
   Posted 6/20/2008 10:30 AM (GMT -6)   

I've always said, "do your research, talk to people, then you decide what treatment is right for you".

For some, the treatment could be waiting, hormones, radiation, surgery, or diet.

In my case, the urologist & surgeon both felt confident that it was contained within the capsule. Given this information, I wanted the cancer OUT! I couldn't feel at ease knowing that it was inside me - with the potential of it spreading.  

For anyone deciding on diet change as your treatment, I say, "Good luck and I really hope it works for you". 


Phillysub.

Age: 51
Last PSA before diagnosis: 2.9
Diagnosed: Oct 2007
Gleason: 3+3=6
RALP surgery: Jan 23, 2008 (Dr Costas Lallas @ Thomas Jefferson Hospital in Philadelphia)
1st Post-op appt: Feb 1, 2008 (negative margins, cancer contained within the capsule)
1st PSA post-op: May 23, 2008 - <0.1 undetectable


JCL
Regular Member


Date Joined Jul 2007
Total Posts : 242
   Posted 6/21/2008 4:56 AM (GMT -6)   
Personally I'm very skeptical about that article. Yes, eating the right foods and exercising is important and beneficial, but for 20 years before I was diagnosed I was in excellent physical shape running four times a week for 60-80 minutes, lifting weights, kept my weight within my height range, rarely ate meat, ate plenty of fruits, vegetables and grains and drank no alcohol except for one glass of wine five nights a week. It was a lifestyle I chose in part because I did not ever want to get cancer, and besides, it made me feel great. Obviously it didn't work. Although my chance for not having the cancer return is excellent, despite all of the above, I had a more aggressive cancer than what the biopsy indicated. Although I would never suggest to another brother what course of treatment to take, for me, getting the darn cancer out of my body was the only option. I had done plenty or research before I was diagnosed knowing that given my family history, PCa was an issue I was likely going to have to deal with at some point in my life (although I thought it would be in my 70s or 80s, not my late 40s), and the day my surgeon told me I had cancer I didn't have to think twice of what course of treatment to take. I told him right then and there, "I want the DaVinci, Doc. Get the darn thing out of my body. I know the risks and I'm willing to take them." Fortunately, so far, it was the right move. I continue to lead a healthy lifestyle, and I would have it no other way, but it's not a panacea.

We here were dealt a bad hand, that's for sure, but only a fool wouldn't play out his hand, and there are no fools here on this forum. Just be careful on whatever hand you play, brothers.

Jack
Biopsy: Diagnosed March 25, 2007. PSA 3.0. Gleason 6. Five of twelve samples positive with <5% each. No perineural invasion seen.
Surgery: May 21, 2007, Florida Hospital, Orlando,FL
Post-op Pathology: Upgraded to Gleason 7 (3+4), negative margins, negative capsular penetration, negative seminal vesicles, lymph nodes left intact, multifocal perinural invasion, 15% of prosate involving cancer in both lobes. T2c
Continence/Erections Out of pads at five weeks. Fully continent and can achieve erections.
Post Surgery PSA: Five tests, all <0.1
Family history: Great-great grandfather died from PC. My Father had his prostate removed at age 67 in 1997 and has had an undetectable PSA ever since. I was diagnosed at a much earlier age and had a more agressive cancer than my father. Go figure.

Post Edited (JCL) : 6/21/2008 5:07:22 AM (GMT-6)


Swimom
Veteran Member


Date Joined Apr 2006
Total Posts : 1732
   Posted 6/22/2008 7:56 AM (GMT -6)   
One of my dearest friends will endure breast cancer treatment starting with surgery on July 1. Thank the good Lord for common sense! Nancy knows we're given the tools to take care of ourselves, including timely testing and common sense. By using the tools God gave us, she found, and is now able ot treat her cancer while the diagnosis is positive.
 
Nancy is a fit woman not yet 60. She has always, I mean always, done all the right things to keep her mind body and spirit healthy. I don't recall her eating so much as a McDonalds fry, ever! It isn't nearly about lifestyle as it is about exposure and genetics. We can eat our way to perfect health and excersise till we have a body fat of 10% and it still won't do much except make us healthier for the fight. Well, low body fat won't help confused  .  Genetics most influenced my husband's cancers and probably Nancy's as well. Again, if we're all looking for that miracle, the tools have always been there. Not to sound all Sunday or anything but, our life is in his capable hands. How, when and why, we choose to use all of the tools he provides is a choice we're given. All we can do is our best. The rest is out of our hands.
 
Swim
 


corynski
Regular Member


Date Joined Apr 2008
Total Posts : 63
   Posted 6/22/2008 8:43 AM (GMT -6)   
Greetings

I agree that a lifestyle change may well be appropriate for many, and for different reasons. about the time I started recording my PSA's at age 58 I also picked up a book by Dean Ornish advocating a strict, reduced animal fats diet for heart reasons. Whether it helped with my prostate will never be known, but my PSA's stayed fairly level, bouncing around a bit, and only started shooting up when I retired and went back to a higher animal protein diet with more pork and beef. I believe the benefits I received; a lower, more stable weight (165), lower blood pressure (120/70 and down), and a lighter, healthier feeling body, made the change very beneficial.

The body certainly doesn't need all that fat and extra protein from overeating, and when it shows, it needs to go. My weight would go up to 205 and I felt fat and uncomfortable, so I'd find a good diet and drop back to around 170, and the cycle began again. A soy based diet levels off my weight, and that feels good, whatever it does for my prostate.

charley/70/east tn
_____________________________________________________________________________

Pre-Diagnostic PSA record, begun 1995 at age 58..... now 70:
1995 - 1.2, 1997 - 1.7, 1998 - 1.4, 1999 - 1.7, 2000 - 3.4, 2001 - 2.0,
2002 - 4.6 on 6/6, 4.1 on 7/24, 3.5 on 10/1 at urologist's office
2003 - 2.3, 2004 - 2.7, 2005 - 3.2 on 7/15, 2006 - no test????
2007 - 5.8 on 2/5, 5.7 on 6/16
2008 - 10.4 on 2/29, 8.8 on 4/21 --- Scheduled biopsy for 5/6/2008. On a graph, the PSA rise looks exponential, i.e. a growth function.

*****************************************************************
5/22/2008 -- Results of biopsy
4 of 12 cores show adenocarcinoma:
LLM - Gleason 3+3=6, PTI=10%, LM - Gleason 3+3=6, PTI=2%
LLA - Gleason 3+4=7, PTI=25%, LA - Gleason 3+3=6, PTI=20%
Clinical Stage: T2a
Comments:
RLB - There is focal acute prostatitis
LLM - There is focal perineural invasion
LLA - There is focal perineural invasion
Partin Table:
OC - 33%, CP - 52%, SV+ -10%, LN - 4%
No treatment selected yet.....

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