Adenocarcinoma???

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KC9AOP
Regular Member


Date Joined Jun 2008
Total Posts : 85
   Posted 7/3/2008 4:32 PM (GMT -6)   
I just got Dad's records and they state he had Adenocarcinoma. Can anyone tell me what that means??
I am age 47 - Father, Paternal Uncle and Maternal Grandfather had/have Prostate Cancer. Father 72 years old, PSA = 10.6 Gleason = 5 + 5 = 10 (very aggressive) and high involvement in all cores. Seed therapy is the only option. Father died cancer free.
6/4/08 - At physical DRE normal, PSA test returns 4.4
6/20/08 - First Urologist visit. DRE and ultrasound finds nothing conclusive. Doctor says biopsy is the only safe way to go. Prostate volume is 40 grams.


Swimom
Veteran Member


Date Joined Apr 2006
Total Posts : 1732
   Posted 7/3/2008 4:39 PM (GMT -6)   
Prostate cancer
 


KC9AOP
Regular Member


Date Joined Jun 2008
Total Posts : 85
   Posted 7/3/2008 4:50 PM (GMT -6)   
swimom said...
Prostate cancer

Nothing more than that???

It there anything more? Something about the type or aggression?

The gleasons were

5 + 5 = 10 90%
5 + 5 = 10 80%
5 + 3 = 8 90%
3 + 4 = 7 95%
5 + 3 = 8 85%
5 + 3 = 8 80%
I am age 47 - Father, Paternal Uncle and Maternal Grandfather had/have Prostate Cancer. Father 74 years old, PSA = 10.6 Gleason = 5 + 5 = 10 (very aggressive) and high involvement in all cores. Seed therapy is the only option. Father died cancer free.
6/4/08 - At physical DRE normal, PSA test returns 4.4
6/20/08 - First Urologist visit. DRE and ultrasound finds nothing conclusive. Doctor says biopsy is the only safe way to go. Prostate volume is 40 grams.
7/08 - deciding if I want stereotactic transpareneal prostate biopsy or rectal


jetguy
Veteran Member


Date Joined Sep 2006
Total Posts : 741
   Posted 7/3/2008 5:01 PM (GMT -6)   

I think that adenocarcinoma is cancer of a gland, but I'm no expert.  The prostate is a gland.  Someone smarter than I should check in soon.

Regards,

Bill


August of 2006, PSA up to 4.2 from 2.7 one year ago. 
October free and total PSA 12% free and 5.0 total.
A month, or so later, 4.7.
Late in the year decide on Image Guided IMRT.
Begin 43 treatments on January 23, 2007 and finish on March 23.
Four month post treatment PSA is 1.9.
Seven month PSA is 0.8.


Swimom
Veteran Member


Date Joined Apr 2006
Total Posts : 1732
   Posted 7/3/2008 5:02 PM (GMT -6)   
KC,

Oh my, that is a serious diagnosis. A Gleason 10 is as high as it gets for a Gleason and the % with so many cores is serious involvement. A very large portion of his prostate seems to have been infiltrated by cancer. How it never spread to other parts is a gift not to be questioned I'd say.

Swim
 


KC9AOP
Regular Member


Date Joined Jun 2008
Total Posts : 85
   Posted 7/3/2008 5:08 PM (GMT -6)   
swimom said...
KC,

Oh my, that is a serious diagnosis. A Gleason 10 is as high as it gets for a Gleason and the % with so many cores is serious involvement. A very large portion of his prostate seems to have been infiltrated by cancer. How it never spread to other parts is a gift not to be questioned I'd say.

Swim

Swim,

Dad's doctor called me today and left me his home phone to call him back. His actual home phone number!!!! I'm going to call him and get all of the info I can.

Thanks for that insight. There was a kidney scan and a bone scan done too. The kidney had a cyst and the bones were clear but had degenerative disease like arthritis. That's all. Since he was 74 there was no surgical option. His doctor, Brian J. Moran at the Chicago Prostate Center, is a specialist in a new isotope seed that really seemed to do the trick.

I feel blessed hat he is taking an interest in me. I hope this is a very early diagnosis and that I can be done with this now at age 47 instead of 74.
I am age 47 - Father, Paternal Uncle and Maternal Grandfather had/have Prostate Cancer. Father 74 years old, PSA = 10.6 Gleason = 5 + 5 = 10 (very aggressive) and high involvement in all cores. Seed therapy is the only option. Father died cancer free.
6/4/08 - At physical DRE normal, PSA test returns 4.4
6/20/08 - First Urologist visit. DRE and ultrasound finds nothing conclusive. Doctor says biopsy is the only safe way to go. Prostate volume is 40 grams.
7/08 - deciding if I want stereotactic transpareneal prostate biopsy or rectal


KC9AOP
Regular Member


Date Joined Jun 2008
Total Posts : 85
   Posted 7/3/2008 5:09 PM (GMT -6)   
swimom said...
KC,

Oh my, that is a serious diagnosis. A Gleason 10 is as high as it gets for a Gleason and the % with so many cores is serious involvement. A very large portion of his prostate seems to have been infiltrated by cancer. How it never spread to other parts is a gift not to be questioned I'd say.

Swim

BTW, I'm a religious guy so I know how it happened.. 'Nuf said
I am age 47 - Father, Paternal Uncle and Maternal Grandfather had/have Prostate Cancer. Father 74 years old, PSA = 10.6 Gleason = 5 + 5 = 10 (very aggressive) and high involvement in all cores. Seed therapy is the only option. Father died cancer free.
6/4/08 - At physical DRE normal, PSA test returns 4.4
6/20/08 - First Urologist visit. DRE and ultrasound finds nothing conclusive. Doctor says biopsy is the only safe way to go. Prostate volume is 40 grams.
7/08 - deciding if I want stereotactic transpareneal prostate biopsy or rectal


BillyMac
Veteran Member


Date Joined Feb 2008
Total Posts : 1858
   Posted 7/3/2008 6:32 PM (GMT -6)   
KC9AOP,
You may find the article at this site:
www.stjohn.org/InnerPage.aspx?Pageid=1446
explains fairly well the meaning of Gleason and stage. When a biopsy is taken a thin core is punched out of the prostate by the needle. These are done at various points in the prostate and varying lengths of tissue. The percentages you quoted are the percentage of the sample that contained tumour while the Gleason grade is an indication of the aggressiveness of the tumour within that sample. His PSA is not really high so that may indicate that it has not spread far beyond the prostate. Adenocarcinoma, as Jetguy says is cancer of a gland.
1/05 PSA----2.9 3/06-----3.2 3/07-------4.1 5/07------3.9 All negative DREs
Aged 59 when diagnosed
Biopsy 6/07----4 of 10 cores positive for Adenocarcinoma-------bummer!
Core 1 <5%, core 2----50%, core 3----60%, core 4----50%
Biopsy Pathologist's comment:
Gleason 4+3=7 (80% grade 4) Stage T2c
Neither extracapsular nor perineural invasion is identified
CT scan and Bone scan show no evidence of metastases
Da Vinci RP Aug 10th 2007
Post-op pathology:
Positive for perineural invasion and 1 small focal extension
Negative at surgical margins, negative node and negative vesicle involvement
Some 4+4=8 identified ........upgraded to Gleason 8
PSA Oct 07 <0.1 undetectable
PSA Jan 08 <0.1 undetectable
PSA April 08 <0.1 undetectable


smilingoldcoot
Regular Member


Date Joined Jan 2008
Total Posts : 338
   Posted 7/3/2008 6:55 PM (GMT -6)   

I am confused?  Your sig says dad died? You have not had a biopsy yet?

Who are the gleason scores for?

RIchard


Retired USAF Richard & Debbie on The Shores of Toledo Bend Lake Louisiana
Biospy 1/10/08 Gleason 10, Stage T1C  8 of 12 samples positive all Less Than 5% 
Jan & Feb & Mar all tests clear
MD Anderson = No surgery and No Proton only Hormone and IMRT
Contacted with Loma Linda and UFPTI in FL
Started Treatment at the U of Florida Proton Therapy Institute in April 2008
May 2, 2008 LUPRON & Casodex
IMRT to started  5/27/2008 Will get 42 treatments 25 IMRT and then 17 Proton
Turn Stumbling Blocks into Steping Stones and Keep Smiling
Our Journey is on WWW.GLEASON10.COM
 


Ken S
Regular Member


Date Joined Nov 2006
Total Posts : 120
   Posted 7/4/2008 7:36 AM (GMT -6)   
KC9AOP,

I'm confused also but if I reading between the lines correctly, these are your numbers? Is that correct?

Ken
Age 54 (2006)
PSA: 2005 - 3.2, 2006 - 3.7
Biopsy 8/06, Gleason 6 (3+3), T1c
Radical Retropubic Prostatectomy 11/3/06
Memorial Hospital, Pawtucket, RI
Post-Op Biopsy, still Gleason 6 (3+3),
T2c, right apical margin positive
CT Scan 1/07, tumor discovered on right
kidney (unrelated to PCa)
Partial Nephrectomy 3/9/07
R.I. Hospital, Providence, RI
IMRT (37 Treatments) 4/23/07 - 6/14/07
PSA: 11/07 - less then 0.01
4/08 - 0.04


smilingoldcoot
Regular Member


Date Joined Jan 2008
Total Posts : 338
   Posted 7/4/2008 6:24 PM (GMT -6)   
Those could not be his numbers if he has not even had a biopsy done!
 
I want to see more information here or I will dismiss this as a hoax.
 
Richard sad
Retired USAF Richard & Debbie on The Shores of Toledo Bend Lake Louisiana
Biospy 1/10/08 Gleason 10, Stage T1C  8 of 12 samples positive all Less Than 5% 
Jan & Feb & Mar all tests clear
MD Anderson = No surgery and No Proton only Hormone and IMRT
Contacted with Loma Linda and UFPTI in FL
Started Treatment at the U of Florida Proton Therapy Institute in April 2008
May 2, 2008 LUPRON & Casodex
IMRT to started  5/27/2008 Will get 42 treatments 25 IMRT and then 17 Proton
Turn Stumbling Blocks into Steping Stones and Keep Smiling
Our Journey is on WWW.GLEASON10.COM
 


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 7/4/2008 8:34 PM (GMT -6)   
I think the numbers and info he is using is from his deceased Dad's path and biopsy report, and his Dad died cancer free.  The poster has a 4.4 psa and no detectable anything with DRE and ultrasound and is waiting to have or is trying to decide if he wants a biopsy for himself as recommended by his doctor, considering his Dad's history of high-risk PCa.

James C.
Co-Moderator- Prostate Cancer Forum

Age 61
4/19/07 PSA 7.6, referred to Urologist, recheck 6.7
7/11/07 Biopsy- 16 core samples, size of gland around 76 cc. Staging pT2c
7/17/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/24/07 (open) Retropubic Radical Prostatectomy performed
9/26/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
10/15/07 ED- begin 50mg Viagra and Vacurect pump nightly, Fully continent
1/14/08 Caverject started/stopped, aching. 2/24/08 .5ml Bimix started-success
7/4/08 ED- Viagra, pump continues, no response- Trimix .10ml x 2 weekly continues
Post Surgery PSA's:  3 mts-0, 6 mts.-0


KC9AOP
Regular Member


Date Joined Jun 2008
Total Posts : 85
   Posted 7/7/2008 10:23 AM (GMT -6)   
James C. said...
I think the numbers and info he is using is from his deceased Dad's path and biopsy report, and his Dad died cancer free. The poster has a 4.4 psa and no detectable anything with DRE and ultrasound and is waiting to have or is trying to decide if he wants a biopsy for himself as recommended by his doctor, considering his Dad's history of high-risk PCa.

You are absolutely correct. All of the information in this thread regards my deceased father's diagnosis and course of therapy.

I'm still collecting information and saw the pathology report, therefore my question.

Thanks to all who are posting answers for me. I do appreciate all of your input and support.

It may look like I've disappeared every now and then. Life gets busy and I can't spend time on the boards consistently. Please trust that I'm here and active.

When I do my biopsy I'll be sure to post results (and update my sig).
I am age 47 - Father, Paternal Uncle and Maternal Grandfather had/have Prostate Cancer. Father 74 years old, PSA = 10.6 Gleason = 5 + 5 = 10 (very aggressive) and high involvement in all cores. Seed therapy is the only option. Father died cancer free.
6/4/08 - At physical DRE normal, PSA test returns 4.4
6/20/08 - First Urologist visit. DRE and ultrasound finds nothing conclusive. Doctor says biopsy is the only safe way to go. Prostate volume is 40 grams.
7/08 - deciding if I want stereotactic transpareneal prostate biopsy or rectal


FLHW(David E)
Regular Member


Date Joined Nov 2007
Total Posts : 201
   Posted 7/7/2008 2:54 PM (GMT -6)   
BTW - a definition of Adenocarcinoma can be found at:

http://en.wikipedia.org/wiki/Adenocarcinoma
Dx'd 2/18/05
PSA 271, bone mets, lymph node involvement
Gleason Score: 7
Current (6-30-08)
PSA: 53.40
Taxotere + Prednisone + Atrasentan
[started June 9th]
Clinical Trial:
http://www.clinicaltrials.gov/ct2/show/NCT00134056?term=prostate+AND+atrasentan&rank=2
Lupron
Personal Blog:
prostatecancerat42.blogspot.com

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