First injection therapy today

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BamaCoast
Regular Member


Date Joined Apr 2008
Total Posts : 39
   Posted 7/8/2008 5:57 PM (GMT -6)   
I had my first injection today by my local Urologist. He started with 5 mg's of caverject. In his words it was a low dosage but my gosh did it work for about 2 1/2 hours. Thank God he did not start any higher. He told me that I would probably experience some throbbing because it had been so long since I had an erection. The throbbing was tough. I have read on this forum were many had experience pain with caverject and switched to trimix or bimix.
 
I have another appointment Thursday to get the injection amount just right. I am thinking the dosage needs to go down. I am wondering if the throbbing will continue or is this just a side effect of caverject that will not get any better?
 
Has anyone had a similiar experience and is there a difference in pain or throbbing? If this is what caverject will continue to do then I will be talking to my Urologist Thursday about changing to something else... The results was great except for the throbbing pain. Any advice will be appreciated.
BamaCoast - Kenny & Renae
from the Gulf Coast of Alabama
Age 51
Di Vinci Robotic Surgery March 5th, 2008
by Dr. Scott Tully
PSA 3.5  Gleason 3+4= 7
Confined to Prostate
1st PSA 6-20-08 .0 negative
Dry approximately 6-15-08
 
 


41diagnosed
Regular Member


Date Joined Jun 2007
Total Posts : 176
   Posted 7/8/2008 6:43 PM (GMT -6)   
At first I was using Trimix and experienced the same. I found however I could actually fall asleep in that state so "before bed activity" helped the situation.

I did switch to Bimix and it worked wonders. However it was not quite as reliable. Then I still had the Trimix and inadvertantly used it again. And no pain. So now I can use either and both seem to work well.

I have noticed that if I use it multiple days in a row, it seems less effective than if there a 2-3 days between uses. OK, I hope that wasn't TMI!
 
42 yo. now
 
5/07 PSA 4.65 at routine physical
6/07 biopsy positive for cancer...Gleason 3+4...diagnosed at 41 y.o.
6/07-9/07 manic research and interviews with physicians across the country in search of the "right" decision.  I went to Mass General in Boston, Loma Linda, University of Chicago and Northwestern.
9/17/07 - Radical Retropubic Prostatectomy Surgery at Northwestern Memorial in Chicago by Dr. William Catalona.  Thankful the father of the PSA test was right here in Chicago.
 
Post op pathology was Gleason 3+4 with negative margins, no seminal vesicale involvement, no lymphatic or vascular invasion, bladder and urethral free and tumor volume was 5% of 27.3g.  
 
9/27/07 - Catheter removal...let the games begin...
 
12/07 - Threw out the pads.  I only had to use 1 pad per day for protection against minor drips. 
 
I started Trimix 8 weeks after surgery with success.
 
I hope someday I won't need injections, but I hope more that my PSA stays at 0 forever.
 
 
 


DanmanBob
Regular Member


Date Joined Feb 2008
Total Posts : 467
   Posted 7/8/2008 6:55 PM (GMT -6)   

PGE-1, aka alprostadil, is the ingredient in Caverject that causes aching in about 50% of the men who use it.

The same drug is found, in lesser amounts, in trimix.  More men tolerate trimix than Caverject.

Bimix, which some find not to be as consistent as the first two mentioned, does NOT contain the PGE-1/alprostadil and no one (that I have heard of) has aching from that formula.

I have both trimix and bimix and so far have had similar results with both....but with moderate aching from the trimix.



Danman Bob, Born 1951
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14; Biopsy result - 9 of 12 sticks showed cancer
Post-op pathology stated that cancer was confined to the prostate
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of late April 2008)
100 MG Viagra 3 times a week beginning December 2007
Osbon Erec-Aid Esteem manual pump for therapy beginning mid-February 2008
30 MG papaverine/1 MG phentolamine bimix injections beginning late April 2008
Five week post-op PSA 0.2, five month post-op PSA 0.1, next test August 2008


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 7/8/2008 8:01 PM (GMT -6)   
My experience has been similar to DanmanBob's.  The caverject gave me some really intense aching and throbbing, so I moved to bimix, then to trimix.  I used the same formula of the 2 bimix chemicals, but added 2.5 mcg of Prostaglandin, rather than the more usual 10 or 20 mcg, so I get a little boost from it, without the ache and throbbing from straight caverject.  So far, its working good, with little sensation of anything to tell me it is different from bimix.

James C.
Co-Moderator- Prostate Cancer Forum

Age 61
4/19/07 PSA 7.6, referred to Urologist, recheck 6.7
7/11/07 Biopsy- 16 core samples, size of gland around 76 cc. Staging pT2c
7/17/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/24/07 (open) Retropubic Radical Prostatectomy performed
9/26/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
10/15/07 ED- begin 50mg Viagra and Vacurect pump nightly, Fully continent
1/14/08 Caverject started/stopped, aching. 2/24/08 .5ml Bimix started-success
7/4/08 ED- Viagra, pump continues, no response- Trimix .10ml x 2 weekly continues
Post Surgery PSA's:  3 mts-0, 6 mts.-0


BamaCoast
Regular Member


Date Joined Apr 2008
Total Posts : 39
   Posted 7/8/2008 9:07 PM (GMT -6)   
I will talk to my Urologist Thursday about the pain and see if we can go another route. Thanks for the info.
BamaCoast - Kenny & Renae
from the Gulf Coast of Alabama
Age 51
Di Vinci Robotic Surgery March 5th, 2008
by Dr. Scott Tully
PSA 3.5  Gleason 3+4= 7
Confined to Prostate
1st PSA 6-20-08 .0 negative
Dry approximately 6-15-08
 
 


Ripandburn
Regular Member


Date Joined Aug 2007
Total Posts : 125
   Posted 7/9/2008 6:05 AM (GMT -6)   
I swear by the Bimix. After the 1st injection of Caverject in the office, I knew that I did not want to use Caverject. I insisted that the Doc write an RX for the Bimix. It will be 1 year for me on 7/16 and I use the Bimix 2x per week with no pain, and it has been 100% reliable for me. But, I think that it is important to hit the proper injection site to help with reliability. I am at less than .2 mg of Bimix right now.
52 years old
T1c 3+3=6
DaVinci July 16, 2007
largest cancer .2mm
Bladder Sling installed during prostate removal
nerve sparing with both nerve bundles intact
all cancer contained within prostate nothing near margins
11 weeks post-op - no more pads
3 PSA's all < .1 - Undetectable

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