New here, injection question

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New Member

Date Joined Jul 2008
Total Posts : 8
   Posted 7/10/2008 1:02 AM (GMT -6)   
I just discovered this forum and it looks very interesting.
Its a year since my RP and I am getting very concerned about the complete lack of erections, even with pills. I am getting more concerned that this is not going to get better since its been nearly a year.
I do get erections with trimix, but I find them pretty painful and not easy to use in intercourse, even though they look like real erections. They seem to last for 2 hours, but are not very good.
I month ago I notices some lumps in the penis and that it was slightly bent to the left and there is a dent in it. This may have been there for months, but I thought it was just a side effect of the injections. The urologist says its a little Peronie's disease. I wonder whether this is the cause of the problem.
Any suggestions on the injections?
Anybody with an encouraging word?
I can use one.
PSA jumped from baseline of 3 to 7.6 on 1/06 at age 51
Biopsy 4/06, negative
PSA still elevated for a year
Biopsy 5/07, one core positive at 1%, Gleason 3+3
open RP on 8/30/07 at Johns Hopkins at age 52
Tumor volume "miniscule", 3+3, large prostate
No pads within 2 weeks of catheter removal, urine control not a problem
Use vacuum device to stretch out
No erections without Trimix, erections painful
5 mg Cialis daily (only started this a month ago)
Noticed raisin size lump in penis a month ago, urologist says its Peronie's disease
Very discouraged

Veteran Member

Date Joined Feb 2008
Total Posts : 1858
   Posted 7/10/2008 8:00 AM (GMT -6)   
Welcome to the forum and you have raised an often discussed thread. You'll find much valuable information here and very helpful members with a lot of sound information. Quite a lot of men (I read about 40%) using injections of trimix or Caverjet experience pain or aching. You'll find many members here have switched to bimix or at least reduced the ingredient in trimix that causes the pain. If you put either bimix or trimix in the "search site"box it will take you to many threads discussing the issues you raised. I am sure many other members will chime in as well.
1/05 PSA----2.9 3/06-----3.2 3/07-------4.1 5/07------3.9 All negative DREs
Aged 59 when diagnosed
Biopsy 6/07----4 of 10 cores positive for Adenocarcinoma-------bummer!
Core 1 <5%, core 2----50%, core 3----60%, core 4----50%
Biopsy Pathologist's comment:
Gleason 4+3=7 (80% grade 4) Stage T2c
Neither extracapsular nor perineural invasion is identified
CT scan and Bone scan show no evidence of metastases
Da Vinci RP Aug 10th 2007
Post-op pathology:
Positive for perineural invasion and 1 small focal extension
Negative at surgical margins, negative node and negative vesicle involvement
Some 4+4=8 identified ........upgraded to Gleason 8
PSA Oct 07 <0.1 undetectable
PSA Jan 08 <0.1 undetectable
PSA April 08 <0.1 undetectable

James C.
Veteran Member

Date Joined Aug 2007
Total Posts : 4463
   Posted 7/10/2008 9:30 AM (GMT -6)   
  tongue    Hi ~leucadiabeach (Dave) and Loved Ones,


Welcome   to  ~ HealingWell ~




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 Click  on  link  below for important information that will help you ~ help us!!


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Welcome ~ New Friend from all the members here... on



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Regular Member

Date Joined Feb 2008
Total Posts : 467
   Posted 7/10/2008 9:35 AM (GMT -6)   
If you have a minor case of Peyronie's, it typically would not prevent usuable erections.
I have had Peyronie's for 24 years and pre-surgery had very good erections.
Which trimix formula are you using?  What dose?  If the erections are not good enough for intercourse, have you tried a higher dose?
Bimix users report no aching.  Have you considered that option?
Good luck.
Danman Bob, Born 1951
Nerve-sparing, open prostate surgery November 13, 2007
Gleason score 9, PSA 14; Biopsy result - 9 of 12 sticks showed cancer
Post-op pathology stated that cancer was confined to the prostate
Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of late April 2008)
100 MG Viagra 3 times a week beginning December 2007
Osbon Erec-Aid Esteem manual pump for therapy beginning mid-February 2008
30 MG papaverine/1 MG phentolamine bimix injections beginning late April 2008
Five week post-op PSA 0.2, five month post-op PSA 0.1, next test August 2008

James C.
Veteran Member

Date Joined Aug 2007
Total Posts : 4463
   Posted 7/10/2008 9:39 AM (GMT -6)   
Dave, hello and welcome.  AS you probably know, it can take up to 3 years or even never for function to return.  You don't say wheter you had nerve sparing surgery, but reading your stats, I'm guessing you did and the nerves are intact but still regenerating and healing.  I am only 3 months behind and also have no response to anything but trimix.  My procedure is 50mg generic Viagra nightly, with 2000 mg of L-Arginine, and daily use of a vacuum pump mornings.  I inject with trimix twice weekly, most weeks.  The only thing I can tell you is to continue exercising those blood vessels and nerves and hopefully nature will take its course in healing and reconnecting things for you (and me).  The Pyronnes is a sad fact and result of the injections, most likely, and can be treated easily.  Consult with your doctor as to whether you should continue the injections while being treated.

James C.
Co-Moderator- Prostate Cancer Forum

Age 61
4/19/07 PSA 7.6, referred to Urologist, recheck 6.7
7/11/07 Biopsy- 16 core samples, size of gland around 76 cc. Staging pT2c
7/17/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/24/07 (open) Retropubic Radical Prostatectomy performed
9/26/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
10/15/07 ED- begin 50mg Viagra and Vacurect pump nightly, Fully continent
1/14/08 Caverject started/stopped, aching. 2/24/08 .5ml Bimix started-success
7/4/08 ED- Viagra, pump continues, no response- Trimix .10ml x 2 weekly continues
Post Surgery PSA's:  3 mts-0, 6 mts.-0

Regular Member

Date Joined Oct 2007
Total Posts : 300
   Posted 7/10/2008 2:01 PM (GMT -6)   
I had a similar situation with injections, a small lump and curvature. It was temporary for me. My Uro said that it was from injecting in the wrong area. He said not to inject if there is a lot of resistance. I did anyway and that is what happened so maybe it will go away. It took about a month and I was very concerned. Just a thought.
Age 65
Diagnosed 10/12/07
PSA 6.3
Biopsy 18 core samples, 2 positive <5%
Stage T1a Gleason 6 (3+3)
LRP  1/29/08
Gleason 7 (3+4)
1 positive margin (.3cm)
5/15/08- 1st Post-Op PSA 0.07 Undetectable

Regular Member

Date Joined Apr 2008
Total Posts : 206
   Posted 7/10/2008 10:23 PM (GMT -6)   
It does take a long time for those nerves to return to function, i am over a year post surgery (also open RP with nerve sparing ) and just in the last 3 months start seeing real improvement but still only at 80 to 90% function now , it ca take up tp 2 years to see improvement , some have their erections return after 2 years or more.
keep hoping
and good Luck
GB :-) :-)
April 2007 PSA 8.4 for last 6 months biopsy shows PC 3+3=6
June 13 2007 Nerve Sparing open RP / Dr. Christopher Johnson at St. Francis Hospital NY.
4 days later home for Fathers Day, and Catheter.
Removal of catheter 10 days later , incontinence not an issue, no pads used from the get go.
1 month PSA next to not detected

ED is a longer battle:
1 month out start using occasionally Cialis and 50MG Viagra to promote blood flow with no response.
3 months and 6 months PSA not detected
ED 6 months mark starting with VED therapy and being more aggressive with meds , in addition taking Folgard supplement daily.
April 2008 : 10 month out and start seeing some serious improvements with ED while using Meds and VED , can achieve erections, Mid nights erections almost on a regular basis , and uncontrolled 90 % erections spontaneously.
1 year visit on June 13 2008 woohoooo!!!

ED: With Viagra Usable erection for intercourse , AND AT 80% without any medications !!
Fully continent since removal of catheter.
PSA one year : 0.0 as of 6/13/ 2008 BIG Wooohoooooooooo!!!!

Regular Member

Date Joined Dec 2006
Total Posts : 357
   Posted 7/11/2008 12:05 AM (GMT -6)   
I had/have Peyronie's as well, developed post surgery and also from injections. My doctor put me on pentoxyfyline, L-arginine and daily (generic) Viagra or Levitra; I supplement this with vitamin E, which I have heard others do (my doctor said the vitamin E amounts to chicken soup for a cold, but I take it). It mostly reversed, though I think a bit of scar tissue remains.

learning to do injections properly is key, which takes practice, at least it did for me. But, having a usable erection so far outweighs the risk of Peyronie's. Also, I had pain with prostaglandin and trimix, which caused me to switch to bimix.

Prostate cancer diagnosed: May 15, 2006 (age 40)
Gleason score: pre-surgery 3+3=6; post-surgery 3+4=7
daVinci radical prostatectomy: July 25, 2006
size of tumor: approx 1.1 inches; negative margins from surgery

- number of pads/day at 3 months after surgery: 3 to 5
- number of pads/day at 4 months after surgery: 1 to 2
- number of pads/day at 6-18 months after surgery: 0 to 1

- 1st post-surgery PSA: 0 (Nov 2006); 2nd post-surgery PSA: 0 (Feb 2007); - 3rd post-surgery PSA: 0 (May 2007);
4th post-surgery PSA: 0 (June 2007); 5th post-surgery PSA: 0 (Dec 2007); 6th post-surgery PSA: 0 (June 2008)

The search for timber: took Viagra/Cialis approx. every other day, ErecAid once a day, injections. Peyronie's diagnosed 7/5/07. Now on daily Cialis, L-arginine and pentoxyfylline. Peyronies has stabilized and significantly reversed.

- PGE1 batting average: .364 (4 for 11)
- Bimix #3 batting average: .722 (13 for 18) Bimix #1 batting average (17 for 18) = .944
- Trimix batting average: .500 (1 for 2) Grand total 35 for 49 = .714

"Lost in the valley without my horses, no one can tell me what my remorse is..."

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