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Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 8/3/2008 12:57 PM (GMT -6)   
I assume that most of the old-timers don't post on this site for one reason or another and I include myself in that group. However, I made a promise to Susan (myman) that I would post one more time, about a clinical trial I am about to join, in the hope that someone else here may benefit from it.

The drug, Sprycel (generic name tasatinib) is made by Bristol-Myers Squibb (BMS). It has shown great success in chronic myelogenous leukemia (CML) patients who no longer respond to the old standard Gleevec and BMS thinks/hopes it will be effective against solid tumors and is apparently starting with hormone refractory PCa. Sprycel is a tablet which is taken at home every day and is given in conjunction with Taxotere infusions given every twenty-one days.

Wikipedia and Google speak mostly to Sprycel vs. CML, but the number of Sprycel vs. PCa links seems to be growing.

The lead doctor is John C. Araujo, MD, PhD, my doc at M.D. Anderson in Houston, but, the trial is being conducted at a number of hospitals around the country.

-Les
1/2005 Dx PSA 26.5 Gleason 7 (4+3) @Age 61
1/2005 Start Casodex and Zoladex
PSA drops to <0.01
7/2005-8/2005 5 weeks of IMRT and then HDR brachy
1/2007 Rad Oncologist orders CT scan of pelvis
because of complaints of pain in both thighs
MRI confirms pain not caused by cancer BUT
1/2007 CT scan of pelvis picks up a nodule at bottom of left lung
5/2007 CT scan of lungs shows 1/2007 nodule has grown and
there are numerous nodules on both lungs.
6/2007 Thoracic surgeon removes wedge of left lung for biopsy
6/2007 Path report says 95% chance of metastatic PCa, but she's
never seen cells like this before.
8/2007 2nd opinion at M.D. Anderson in Houston.
They confirm: mutated PCa, very rare, but seen there 2 or
3 times. Recommendation: have CT scans every 6 weeks
and watch for change. At that point start chemo and will
survive for 22 - 24 months thereafter.
PSA still undetectable, but get Lupron shot to bring T down from 27
2/2008 Trip to Houston – PSA now 0.5 and nodules larger. Lupron shot.
6/2008 Trip to Houston - Finally got results from doc. A number of lung nodules have grown, but, more important to him, is the fact that the malignant lesion on my pelvis seems to have flared up and he wants me to start chemo. He said I could wait a few months, but I told him I want to start now. He to get me signed up for a clinical trial in nearby NY.


Tim G
Veteran Member


Date Joined Jul 2006
Total Posts : 2361
   Posted 8/3/2008 2:20 PM (GMT -6)   
Les--I'm glad you posted an update at Susan's behest about the clinical trial and chemotherapy you are undergoing.  I had wondered about this since you mentioned that you would be doing this.  It sounds very hopeful and promising.  And as you write, others in a similar situation may be interested in learning more about this. Take care and hang in there...Tim

mvesr
Veteran Member


Date Joined Apr 2007
Total Posts : 823
   Posted 8/3/2008 6:11 PM (GMT -6)   
Hi Les

It is good to hear from you. I hope this works for you.

Mika
age at dx 54 now 56
psa at dx 4.3
got the bad news 1/29/07
open surgery Duke Medical Center 5-29-07
never more than 2 pads
Tossed the pads this spring
ED still a problem
first year PSA less than zero
 


Doting Daughter
Veteran Member


Date Joined Aug 2007
Total Posts : 1064
   Posted 8/3/2008 6:54 PM (GMT -6)   
Glad to see you posting again. I hope you continue to keep us posted on your progress! All the best to you as you move forward with treatment!
Father's Age 62 (now 63)
Original Gleason 3+4=7, Post-Op Gleason- 4+3=7,
DaVinci Surgery Aug 31, 2007
Focally Positive Right Margin, One positive node. T3a N1 M0.
Bone Scan/CT Negative (Sept. 10, 2007)
Oct. 17 PSA 0.07
Nov. 13 PSA 0.05
Casodex adm. Nov 07, Lupron beg. Dec 03, 2007 2 yrs
Radiation March 03-April 22, 2008- 8 weeks 5x a week
July 2, 08 PSA <.02
Praying for a cured dad.

Co-Moderator Prostate Cancer Forum


M. Kat
Veteran Member


Date Joined Jul 2006
Total Posts : 715
   Posted 8/3/2008 7:53 PM (GMT -6)   
Les, best wishes to you as you continue with another treatment! please check in again as things move along. take care, kat
Husband Jeff 56 years old diagnosed July 27, 2006
PSA 6.5, 2 positive areas in biopsy, Gleason 3+3=6
Radical Retropubic Prostatectomy August 30, 2006
pathology report - all clear - cancer gone
1st post-surgery PSA test <0.1, 2nd post-surgery PSA test <0.1, 3rd PSA <0.1
no more pads Oct 12, 2006
first "real" erection with use of pump 12/16/06
3/07 - occasional dribbles and erections with Cialis and pump
8/07 - 1 yr PSA <0.1
9/1/07 - achieved erection with Viagra - no pump!
3/08 - 18 mo PSA <0.1
switched to Levitra - works much better than Viagra & Cialis - fewer side affects


livinadream
Veteran Member


Date Joined Apr 2008
Total Posts : 1382
   Posted 8/3/2008 9:19 PM (GMT -6)   
Les I can't speak for everyone but I personally value your posts and opinions. Good luck with the upcoming trial, and please keep us posted.

peace and love
Dale
My PSA at diagnosis was 16.3
age 46 (current)
My gleason score from prostate was 4+5=9 and from the lymph nodes was 4+4=8
I had 44 IMRT's
Casodex
Currently on Lupron
I go to The Cancer Treatment Center of America
Married with two kids
latest PSA 5-27-08 0.11
PSA July 24th, 2008 is 0.04
cancer in 4 of 6 cores
92%
80%
37%
28%
 


BillyMac
Veteran Member


Date Joined Feb 2008
Total Posts : 1858
   Posted 8/3/2008 9:32 PM (GMT -6)   
Les,
Good to see you posting. My best wishes and good luck with the upcoming trial and good results from the treatment. Every little victory by each one of us, no matter how uphill our battle against this rotten disease, is a victory for us all. Maybe a little too philosophical but true nevertheless. Please keep us informed of how you go.
Bill
1/05 PSA----2.9 3/06-----3.2 3/07-------4.1 5/07------3.9 All negative DREs
Aged 59 when diagnosed
Biopsy 6/07----4 of 10 cores positive for Adenocarcinoma-------bummer!
Core 1 <5%, core 2----50%, core 3----60%, core 4----50%
Biopsy Pathologist's comment:
Gleason 4+3=7 (80% grade 4) Stage T2c
Neither extracapsular nor perineural invasion is identified
CT scan and Bone scan show no evidence of metastases
Da Vinci RP Aug 10th 2007
Post-op pathology:
Positive for perineural invasion and 1 small focal extension
Negative at surgical margins, negative node and negative vesicle involvement
Some 4+4=8 identified ........upgraded to Gleason 8
PSA Oct 07 <0.1 undetectable
PSA Jan 08 <0.1 undetectable
PSA April 08 <0.001 undetectable
PSA August 08 <.001 undetectable

Post Edited (BillyMac) : 8/4/2008 3:34:30 AM (GMT-6)


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1464
   Posted 8/4/2008 12:13 AM (GMT -6)   
Hey Les,

Yeah, its hard to post here sometimes when the condition we are dealing with does not apply to the majority of people here. However, I take solace just from staying in touch with those that have helped my so much. Its like a friendly touch and reassurance that I am not alone. But that's just me. I don't know much about how you handle your situation except that your words always strike a chord with me.

Best of luck with the trial. You never know what will work in this fight against cancer.

Jim
Age 74. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + 1000 mg L-Arginine + .03 cc Trimix = Excellent Results
PSAs from  1/3/07 - 7/17/08 0.00. 
Next PSA test on 1/28/09
Lung cancer dxed on 5/16/08.  Surgery on 6/25/08  T1N1M0 - Stage IIA  Start chemo in September 08
"Patience is essential, attitude is everything."


norskie
Regular Member


Date Joined Jan 2007
Total Posts : 376
   Posted 8/4/2008 8:15 AM (GMT -6)   
Les

Great to hear from you and just know that we are thinking about you and pulling for good sucess in the trial treatment plan. Stay in touch and good luck my friend

Norskie
norskie
Age 49, PSA 6.22 on 9-26-06
Biopsy 11-01-06, 2 of 13 cores 10% cancer, 2 other cores abnormal Up-dated 20% prostate cancerous
Gleason score 3+3=6 After Surgery Pathology report 4+3=7 a couple agressive Grade 5 cells found
Da Vinci surgery 01-09-07 UW Madison
Pathology Report- cancer 100 % capsual contained 1-18-07
1st & 2nd Post PSA Blood Test .1 and less - Undetectable
3nd Post PSA Blood Test 01-17-07 .3
March 27th PSA .4 Begin Salvage Radiation April, 14 2008
Incontenence-Pad free since end of May 07 4 1/2 months post surgery 
ED back to 95% prior to surgery - no medication required.


Paralleli
Regular Member


Date Joined Jul 2008
Total Posts : 123
   Posted 8/4/2008 11:13 AM (GMT -6)   
Les

Wishing you success in your trial, and my best wishes.
53 yrs
PSA 4.8
T1c – Gleason 3 + 3
IMRT 1/07 thru 2/07 (42 treatments)
PSA 6/07 – 0.76
PSA 12/07 – 0.36
PSA 6/08 – 0.72


Frank1205
Regular Member


Date Joined Feb 2008
Total Posts : 308
   Posted 8/4/2008 1:44 PM (GMT -6)   

Gordy,

Good luck with your trial treatment.  You shall be in my thoughts.  Please keep in touch with us through this site.

Frank

 


Diagnosed 01-08-08 @ 53 years old 
DRE normal - Bouncing PSA for 5 or more years a high of 10
2004 Biospy negative - 2008 Biopsy positive (01-08-08)
10 cores, 1 positive and at 1% of that one core
Current PSA 6 - Bone and Ct scans negative
clinicaly Staged at T1C - Gleason 3+3 = 6
Robotic Da Vinci performed March 27th, 2008
University of Chicago,5 hour surgery , 3 hour recovery
Unexpected Cardiac issues appear and disappear?
Hospital stay 30 hours - Catheter out in 7 days  normaly expected leakage - Erectile funtion back on line 9 days then off again and then back again at 4 months. Better with Viagra
Post Pathology T2C, Gleason 7, 10 % of both portions of prostate, Seminal vessels clear, fat tissue clear,Tumor on top of prostate. 1 positve margin measureing less than .5 ml at urethra and bladder..
Six week PSA < 0.1 Ya Ba Da Ba Dooooooooooo.  Put a steak on the grill Wilma!!!!
4 month PSA <.05 Gen II test.  Urologist wants to hold off on Radiation and watch PSA closely.
Leaning strongly to surveilance with PSA before Radiation. Doc says 50/50 chance of PSA re-occurence.  What happened to 90%.
Next PSA in October..
 
 
 


Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 8/5/2008 8:55 PM (GMT -6)   
Beginning of trial is now pushed back to Monday, 8/11 because blood draw is required 47 hours after start of trial, which would make it Saturday morning and office is closed on Saturday. In addition, blood draw on 7/24 is now too old, so will have new blood draw on Thursday, 8/7. Will also have echo cardiogram on 8/7. Oh, didn't I mention that an echo cardiogram is required before starting trial?

And just to make it a perfect day, we saw breast surgeon today who did biopsy on suspicious area on Carol's breast. Have to wait for Thursday, 8/7 for path report to come back, but surgeon is almost positive it's cancer.

And so it goes......

-Les
1/2005 Dx PSA 26.5 Gleason 7 (4+3) @Age 61
1/2005 Start Casodex and Zoladex
PSA drops to <0.01
7/2005-8/2005 5 weeks of IMRT and then HDR brachy
1/2007 Rad Oncologist orders CT scan of pelvis
because of complaints of pain in both thighs
MRI confirms pain not caused by cancer BUT
1/2007 CT scan of pelvis picks up a nodule at bottom of left lung
5/2007 CT scan of lungs shows 1/2007 nodule has grown and
there are numerous nodules on both lungs.
6/2007 Thoracic surgeon removes wedge of left lung for biopsy
6/2007 Path report says 95% chance of metastatic PCa, but she's
never seen cells like this before.
8/2007 2nd opinion at M.D. Anderson in Houston.
They confirm: mutated PCa, very rare, but seen there 2 or
3 times. Recommendation: have CT scans every 6 weeks
and watch for change. At that point start chemo and will
survive for 22 - 24 months thereafter.
PSA still undetectable, but get Lupron shot to bring T down from 27
2/2008 Trip to Houston – PSA now 0.5 and nodules larger. Lupron shot.
6/2008 Trip to Houston - Finally got results from doc. A number of lung nodules have grown, but, more important to him, is the fact that the malignant lesion on my pelvis seems to have flared up and he wants me to start chemo. He said I could wait a few months, but I told him I want to start now. He to get me signed up for a clinical trial in nearby NY.


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1464
   Posted 8/5/2008 11:28 PM (GMT -6)   
Hey Les,

So sorry to hear about Carol's biopsy and of course we all hope its benign. It seems like it never stops. And I'd rather got through it myself than have MaryLu get cancer.

Hoping for the best for both of you...

Jim
Age 74. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + 1000 mg L-Arginine + .03 cc Trimix = Excellent Results
PSAs from  1/3/07 - 7/17/08 0.00. 
Next PSA test on 1/28/09
Lung cancer dxed on 5/16/08.  Surgery on 6/25/08  T1N1M0 - Stage IIA  Start chemo in September 08
"Patience is essential, attitude is everything."


Tim G
Veteran Member


Date Joined Jul 2006
Total Posts : 2361
   Posted 8/5/2008 11:58 PM (GMT -6)   
I'm so sorry to hear about your wife's possible cancer, Les, on top of all you're going thru. It just doesn't let up does it.

BillyMac
Veteran Member


Date Joined Feb 2008
Total Posts : 1858
   Posted 8/6/2008 4:44 AM (GMT -6)   
Sheesh, there's got to be a whole lot of good news headed your way. You've had way more than your fair share of bad. All the good karma I can muster is headed your way.
Bill
1/05 PSA----2.9 3/06-----3.2 3/07-------4.1 5/07------3.9 All negative DREs
Aged 59 when diagnosed
Biopsy 6/07----4 of 10 cores positive for Adenocarcinoma-------bummer!
Core 1 <5%, core 2----50%, core 3----60%, core 4----50%
Biopsy Pathologist's comment:
Gleason 4+3=7 (80% grade 4) Stage T2c
Neither extracapsular nor perineural invasion is identified
CT scan and Bone scan show no evidence of metastases
Da Vinci RP Aug 10th 2007
Post-op pathology:
Positive for perineural invasion and 1 small focal extension
Negative at surgical margins, negative node and negative vesicle involvement
Some 4+4=8 identified ........upgraded to Gleason 8
PSA Oct 07 <0.1 undetectable
PSA Jan 08 <0.1 undetectable
PSA April 08 <0.001 undetectable
PSA August 08 <.001 undetectable


Every time I see an adult on a bicycle I no longer despair for the human race.
H.G.Wells


M. Kat
Veteran Member


Date Joined Jul 2006
Total Posts : 715
   Posted 8/6/2008 7:09 AM (GMT -6)   
Les and Carol, all the best to both of you.... take care, kat
Husband Jeff 56 years old diagnosed July 27, 2006
PSA 6.5, 2 positive areas in biopsy, Gleason 3+3=6
Radical Retropubic Prostatectomy August 30, 2006
pathology report - all clear - cancer gone
1st post-surgery PSA test <0.1, 2nd post-surgery PSA test <0.1, 3rd PSA <0.1
no more pads Oct 12, 2006
first "real" erection with use of pump 12/16/06
3/07 - occasional dribbles and erections with Cialis and pump
8/07 - 1 yr PSA <0.1
9/1/07 - achieved erection with Viagra - no pump!
3/08 - 18 mo PSA <0.1
switched to Levitra - works much better than Viagra & Cialis - fewer side affects
summer of 2008 - have had a few erections with no drugs! yeah!!


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 8/6/2008 9:55 AM (GMT -6)   
Gordy, here's wishing for good news for you and your wife.  Keep on hanging in there, guy.

James C.
Co-Moderator- Prostate Cancer Forum

Age 61
4/19/07 PSA 7.6, referred to Urologist, recheck 6.7
7/11/07 Biopsy- 16 core samples, size of gland around 76 cc. Staging pT2c
7/17/07 Path report: 3 of 16 PCa, 5% involved, left lobe , GS 3/3:6.
9/24/07 (open) Retropubic Radical Prostatectomy performed
9/26/07 Post-op Path Report: GS 3+3=6 Staging pT2c, 110gms, margins clear
10/15/07 ED- begin 50mg Viagra and Vacurect pump nightly, Fully continent
1/14/08 Caverject started/stopped, aching. 2/24/08 .5ml Bimix started-success
7/31/08 ED- Viagra, pump continues, no response- Trimix .10ml x 2 weekly continues
Post Surgery PSA's:  3 mts-0, 6 mts.-0, 9 mts.-0.


Frank1205
Regular Member


Date Joined Feb 2008
Total Posts : 308
   Posted 8/6/2008 11:15 AM (GMT -6)   

Gordy,

It seems you and Carol have certainly been given a disproportionate share of issues and concerns, to say it lightly.

Take care you two.

Frank

 

 


Doting Daughter
Veteran Member


Date Joined Aug 2007
Total Posts : 1064
   Posted 8/6/2008 6:34 PM (GMT -6)   
Les-
Wishing you and Carol the best in these difficult times. I will definitely be thinking of you both and hoping you both catch a break here soon. Keep us posted.
Father's Age 62 (now 63)
Original Gleason 3+4=7, Post-Op Gleason- 4+3=7,
DaVinci Surgery Aug 31, 2007
Focally Positive Right Margin, One positive node. T3a N1 M0.
Bone Scan/CT Negative (Sept. 10, 2007)
Oct. 17 PSA 0.07
Nov. 13 PSA 0.05
Casodex adm. Nov 07, Lupron beg. Dec 03, 2007 2 yrs
Radiation March 03-April 22, 2008- 8 weeks 5x a week
July 2, 08 PSA <.02
Praying for a cured dad.

Co-Moderator Prostate Cancer Forum


Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 8/6/2008 7:09 PM (GMT -6)   
Thanks from both of us for all your kind thoughts.

-Les
1/2005 Dx PSA 26.5 Gleason 7 (4+3) @Age 61
1/2005 Start Casodex and Zoladex
PSA drops to <0.01
7/2005-8/2005 5 weeks of IMRT and then HDR brachy
1/2007 Rad Oncologist orders CT scan of pelvis
because of complaints of pain in both thighs
MRI confirms pain not caused by cancer BUT
1/2007 CT scan of pelvis picks up a nodule at bottom of left lung
5/2007 CT scan of lungs shows 1/2007 nodule has grown and
there are numerous nodules on both lungs.
6/2007 Thoracic surgeon removes wedge of left lung for biopsy
6/2007 Path report says 95% chance of metastatic PCa, but she's
never seen cells like this before.
8/2007 2nd opinion at M.D. Anderson in Houston.
They confirm: mutated PCa, very rare, but seen there 2 or
3 times. Recommendation: have CT scans every 6 weeks
and watch for change. At that point start chemo and will
survive for 22 - 24 months thereafter.
PSA still undetectable, but get Lupron shot to bring T down from 27
2/2008 Trip to Houston – PSA now 0.5 and nodules larger. Lupron shot.
6/2008 Trip to Houston - Finally got results from doc. A number of lung nodules have grown, but, more important to him, is the fact that the malignant lesion on my pelvis seems to have flared up and he wants me to start chemo. He said I could wait a few months, but I told him I want to start now. He to get me signed up for a clinical trial in nearby NY.


VaFan
Regular Member


Date Joined Mar 2008
Total Posts : 203
   Posted 8/8/2008 12:58 PM (GMT -6)   
Hi Les,

I just read your post and then your wifes bad news too. I'm hoping that its just the opposite of what is expected from the biopsy. I guess there is nothing I can say except that I wish all good for both of you and I'm always thinking about y'all.
Kent got a bit of news too. Found a nodule thats not supposed to be there. Going to Colon/Rectal doctor on the 27th. Just when you think you can take a breath....
Again, please let us know how things are going.
My best
Cindy
Age 51 Kent Cindy 49
January 08 PSA 5.2 round of antibiotics went to 4.3
February 08 another round of antibiotics went to 4.2
March 17,08 had biopsy, 2 days later told cancer was on
one entire side of prostate.
Gleason 3+3
Doctor thinks its best to get the whole prostate with Perineal  Prostatectomy.
Surgery scheduled for this Thursday April 10th. Only took 1 1/2 hours. In recovery 1 hour.  Both nerves were spared.
Home 4-11. Cath out 4-22. Incision looks completly healed on the outside by 4-25.  Incontinence "a thing of the past" as of 5-28
lst PSA 0.04 June 3. YAY!!!
July 08 (3mths post op) Cialis 10 mg every other day. Right now, things are not looking so good in that department. 


Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 8/8/2008 5:23 PM (GMT -6)   
Cindy-

Nope - cancer wins again! But fortunately for us, it's small and the cells are very well differentiated. Surgery (lumpectomy) is scheduled for August 29 and then Carol undergoes 5 days of what sounds like brachytherapy - a balloon is inserted into the (now) empty space with a catheter and a radioactive seed is placed in the balloon for a given amount of time. I haven't had a chance to research the procedure yet.

It never ends, does it? Please know that Carol and I appreciate your kind words and that we've both got our fingers crossed for Kent.

On the other front - my start-of-the-clinical-trial was pushed back from yesterday to next Monday, 8/11. I've been told to bring dvds and lots of reading material. After the one hour infusion at 8 AM, they will be drawing blood hourly for 10 hours.

After a while, all that goes on with Kent, Carol, me and everyone else here starts to sound and feel surreal. It seems as though it can't really be happening to all of us. I don't know, I just don't know.

Be well and good luck on the 27th.

-Les
1/2005 Dx PSA 26.5 Gleason 7 (4+3) @Age 61
1/2005 Start Casodex and Zoladex
PSA drops to <0.01
7/2005-8/2005 5 weeks of IMRT and then HDR brachy
1/2007 Rad Oncologist orders CT scan of pelvis
because of complaints of pain in both thighs
MRI confirms pain not caused by cancer BUT
1/2007 CT scan of pelvis picks up a nodule at bottom of left lung
5/2007 CT scan of lungs shows 1/2007 nodule has grown and
there are numerous nodules on both lungs.
6/2007 Thoracic surgeon removes wedge of left lung for biopsy
6/2007 Path report says 95% chance of metastatic PCa, but she's
never seen cells like this before.
8/2007 2nd opinion at M.D. Anderson in Houston.
They confirm: mutated PCa, very rare, but seen there 2 or
3 times. Recommendation: have CT scans every 6 weeks
and watch for change. At that point start chemo and will
survive for 22 - 24 months thereafter.
PSA still undetectable, but get Lupron shot to bring T down from 27
2/2008 Trip to Houston – PSA now 0.5 and nodules larger. Lupron shot.
6/2008 Trip to Houston - Finally got results from doc. A number of lung nodules have grown, but, more important to him, is the fact that the malignant lesion on my pelvis seems to have flared up and he wants me to start chemo. He said I could wait a few months, but I told him I want to start now. He to get me signed up for a clinical trial in nearby NY.


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 8/8/2008 6:20 PM (GMT -6)   

Les,

I am very sorry to hear this.  All of of our positive thoughts for you both!

Tony

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