Informational Links for PIN or Prostatic Intraepithelial Neoplasia A Premalignant Lesion

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KC9AOP
Regular Member


Date Joined Jun 2008
Total Posts : 85
   Posted 8/7/2008 1:01 PM (GMT -6)   
I don't see a whole lot of information out here for PIN so I thought I'd post a few links for everyone:
 

Precancerous lesions of the prostate.

Prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely pre-invasive stage of adenocarcinoma

Prostate Cancer Research Institute: PIN or Prostatic Intraepithelial Neoplasia A Premalignant Lesion

US News and World Report - Health report on PIN

Contemporary clinical management of isolated high-grade prostatic intraepithelial neoplasia

Wikipedia

Moderrn Pathology - High-grade prostatic intraepithelial neoplasia

Really neat pathology images of PIN and other male genital pathology

Washington University St. Louis - What it is and how to treat it

Clinical trials for men with PIN

What on Earth is PIN? (a 1995 article)

A Study of Pathologists' Responses in the College of American Pathologists Performance Improvement Program in Diagnostic Surgical Pathology:  http://arpa.allenpress.com/arpaonline/?request=get-document&doi=10.1043%2F0003-9985(2001)125%3C0440:HGPIN%3E2.0.CO%3B2


I am age 47 - Father, Paternal Uncle and Maternal Grandfather had/have Prostate Cancer.
Father 74 years old, PSA = 10.6 Gleason = 5 + 5 = 10 (very aggressive) and high involvement in all cores. Seed therapy is the only option. Father died cancer free.
06/04/08 - At physical DRE normal, PSA test returns 4.4
06/20/08 - First Urologist visit. DRE and ultrasound finds nothing conclusive. Doctor says biopsy is the only safe way to go. Prostate volume is 40 grams.
07/11/08 - PSA test returns 4.1. Scheduled the Stereotactic Transperineal Prostate Biopsy for 7/21
07/21/08 - Had the biopsy.  Not so bad but sore on day 2. Back to work tomorrow
07/23/08 - Pathology comes back NO CANCER DETECTED!
08/01/08 - Urologist calls and says Prostatic Intraepithelial Neoplasia ("PIN") was found in my biopsy 

Post Edited (KC9AOP) : 8/7/2008 1:06:16 PM (GMT-6)


Swimom
Veteran Member


Date Joined Apr 2006
Total Posts : 1732
   Posted 8/7/2008 2:16 PM (GMT -6)   
Many studies / journals reoprt that PIN is about 3 years ahead of "cancer" on average. Could PIN never become cancer? SURE!
The word neoplasia / neoplasm means "new growth" in Greek but. to the rest of us it means cancerous growth. I'm not wondering if, I wonder how far out until it becomes untreatable.
 


KC9AOP
Regular Member


Date Joined Jun 2008
Total Posts : 85
   Posted 8/7/2008 2:16 PM (GMT -6)   
Selmer said...
KC9AOP, Nice list of information.

I guess the next question is........other than continuing your follow up screening with your urologist, is there anything else you can do to slow, delay or halt the progression of the PIN from transforming into a Gleason 3+3 outcome?

I don't know the answer, and I'm sure if there are some steps one could take, you'd never be quite sure how any one individual would react.
Never-the-less, I suppose thats the direction I would focus my efforts on.

I see from reading there are a few places where some mixtures of certain herbs, etc are "suggested" to be beneficial, however I also see that some of those doctors doing and reporting the research also have a interest in a company that sells a commercial version of such product.

Example the Life Extension (LEF) group has a article by Aaron E. Katz who I think is well respected, but than again I really wonder if the combination he says was tested is any better than just using some of those ingredients by themselves in a really modified diet that requires no specific branded commercial formula.

http://www.lef.org/magazine/mag2007/apr2007_report_prostate_01.htm

You can read the concept but not buy into the branded product I see he sells elsewhere on the internet. I tend to avoid such "special" formulas and most supplements for that matter. There are only a few "supplements" I bother with if they are really difficult to get in a really healthy diet.
Curcumin for example. Perhaps Selenium and Vit D3 in some cases. I just think the first emphasis is on overall diet rather than some special "stew" of supplements. I'd make significant changes in my overall diet before relying mostly on special supplements

I'm thinking, but don't really know, that the same steps that "might" be beneficial for someone who doesn't have biopsied PIN, are the same steps that "might" prove beneficial for someone with PIN.

But as I always add.......all of these steps if taken, only "might" have some effect. You can never tell what might work, and even after years of doing such, you will never be certain which if any steps made any difference.
Still, if most of the changes are healthy anyway, then why not.

Keep reading and finding the best path for your situation.

Selmer.

Thanks Selmer,

I agree that a whole dietary change rather than a magic pill is much more likely to be beneficial.

From what I've read, there is no prescribed course of action to "cure" PIN. It is simply wait and watch for PCa to hit. PSA and DRE twice a year and a biopsy at least once a year until PCa is found. That's a high level of attention to early detection and I appreciate that but there is nothing preventative offered at all. In addition, current data shows that it can take 5 to 10 years for PCa to hit once PIN is found. So I'm supposed to get a biopsy every year for the next decade or so? Seems a little aimless.

Some suggested that Hormone therapy or radiation could resolve the problem, but there is no study to back up the idea.

I'm going to search harder for cures as opposed to definition of the disease. I'm contacting my oncologist to discuss PIN and to get an idea of where I can find any information on curing it and keeping me from more or less assured PCa.

Jim
I am age 47 - Father, Paternal Uncle and Maternal Grandfather had/have Prostate Cancer.
Father 74 years old, PSA = 10.6 Gleason = 5 + 5 = 10 (very aggressive) and high involvement in all cores. Seed therapy is the only option. Father died cancer free.
06/04/08 - At physical DRE normal, PSA test returns 4.4
06/20/08 - First Urologist visit. DRE and ultrasound finds nothing conclusive. Doctor says biopsy is the only safe way to go. Prostate volume is 40 grams.
07/11/08 - PSA test returns 4.1. Scheduled the Stereotactic Transperineal Prostate Biopsy for 7/21
07/21/08 - Had the biopsy.  Not so bad but sore on day 2. Back to work tomorrow
07/23/08 - Pathology comes back NO CANCER DETECTED!
08/01/08 - Urologist calls and says Prostatic Intraepithelial Neoplasia ("PIN") was found in my biopsy 


Swimom
Veteran Member


Date Joined Apr 2006
Total Posts : 1732
   Posted 8/7/2008 9:56 PM (GMT -6)   
Selmer is right about good dietary habits being of benefit in more ways than one. First, a good diet maintains healthier blood sugar levels and promotes better heart and blood pressure health. Secondly, people who maintian healthy lifestyles are more likely to have annual physicals in general. Even when we cannot alter genetics, we do tend to watch our health more closely therefore catching issues in earlier stages. The Hawthorn effect comes into play....the more we talk about improving healthy habits the more likely we are to do just that.

Swim
 

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