New Medication for ED

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Tim G
Veteran Member

Date Joined Jul 2006
Total Posts : 2361
   Posted 9/1/2008 1:50 PM (GMT -6)   
I want to let those who are experiencing ED know about a new medication  that we are trying.  As you may know, the only thing that has worked for us is penile injections. 
The new medication, which came out this year, is called TriMix-Gel and is injected (needle-less) into the urethra.  It worked for us sufficiently to achieve intercourse.   My urologist also suggested that it could be used in combination with any of the oral meds, which we plan to try.
I had no urethral burning or penile pain (commonly reported with the older intraurethral drug, MUSE).  I have included a link to the web site for anyone interested.  The cost is about $200 (including shipping) for 12 doses. A prescription is required.

Age 59  PSA quadrupled in 1 yr (0.6 to 2.5) 
DRE neg  1 of 12 biopsies pos (< 5%) 
Open surgery June 2006 
Organ confined pT2a  Gleason 5   
Cancer-free for 2 years  PSA's undetectable 

Regular Member

Date Joined Mar 2008
Total Posts : 203
   Posted 9/1/2008 7:14 PM (GMT -6)   
HI Tim

Good to know the info cause we are having no luck whatsoever. Do you know if alldaychemist is involved in this one yet? Its kinda steep for our budget.
Thank you!

Age 51 Kent Cindy 49
January 08 PSA 5.2 round of antibiotics went to 4.3
February 08 another round of antibiotics went to 4.2
March 17,08 had biopsy, 2 days later told cancer was on
one entire side of prostate.
Gleason 3+3
Doctor thinks its best to get the whole prostate with Perineal  Prostatectomy.
Surgery scheduled for this Thursday April 10th. Only took 1 1/2 hours. In recovery 1 hour.  Both nerves were spared.
Home 4-11. Cath out 4-22. Incision looks completly healed on the outside by 4-25.  Incontinence "a thing of the past" as of 5-28
lst PSA 0.04 June 3. YAY!!!
July 08 (3mths post op) Cialis 10 mg every other day. Right now, things are not looking so good in that department. 
Aug 08 PSA 0.04 Yay Again!!

Veteran Member

Date Joined Jul 2006
Total Posts : 686
   Posted 9/2/2008 8:08 PM (GMT -6)   


Hi Tim

I am glad to hear you have had good results with the "tri-mix-gel".  I am currently using bi-mix injections. The straight alprostadil (prostaglandin) injections were very uncomfortable for me, so I went right to the bi-mix.

What other things have you tried?  Have you used injected Caverject or injected tri-mix.  Did you have any problems with them?  The warnings included a possible vaginal burning or itching with your partner, have you noticed that as a problem?

 Has it been around for a while or is it new on the market?   Hope it continues to work well for you.

PSA up to 4.7 July 2006 , bump noted during DRE
Biopsy 10/16/06
T2A, Psa 4.7
Gleason  4+4=8  right side
DaVinci Surgery  January 2007
Post op confirms gleason 4+4=8
No extension or invasion found
No continence problems
PSA 90 day -.01  , 6 month -.01 , 9 month +.02 , 1 year +.02
Using Bi-Mix or VED 

Veteran Member

Date Joined Aug 2007
Total Posts : 1015
   Posted 9/2/2008 11:43 PM (GMT -6)   
Hi Tim,

This sounds a little like Muse in application, but in a gel.

It is very interesting.

Glad to know about it.

Thank you.

Barry ~ (a.k.a. "Idaho")


Da Vinci Surgery July 31, 2007… 54 on surgery day
PSA 4.3  Gleason 3+3=6  T2a  Confined to Prostate

1st PSA  09/11/2007  <0.04 (undetectable)

2nd PSA 12/10/2007  <0.04

3rd PSA  03/17/2008  <0.04

4th PSA  06/17/2008  <0.04

My web site:

Tim G
Veteran Member

Date Joined Jul 2006
Total Posts : 2361
   Posted 9/18/2008 8:09 PM (GMT -6)   
Sorry for my delay in replying to responses, but my dearly beloved and I have been on vacation for two weeks. 
This is a new drug and  only came on the market in 2008.  I doubt if it can be gotten at AllDayChemist. The price is  about $15 per dose.  Our insurance doesn't cover it.
What we've tried is oral meds (no), vacuum (no), Caverject (yes, but penile pain), and QuadMix injections (yes).  So far this drug has worked sufficient for intercourse.
My wife has had no burning/itching/other problems with any of the drugs we've used.
Age 59  PSA quadrupled in 1 yr (0.6 to 2.5) 
DRE neg  1 of 12 biopsies pos (< 5%) 
Open surgery June 2006 
Organ confined pT2a  Gleason 5   
Cancer-free for 2 years  PSA's undetectable 

New Member

Date Joined Oct 2008
Total Posts : 1
   Posted 10/6/2008 8:41 PM (GMT -6)   
I have been very interested in the Trimix-Gel. I asked my urologist to prescribe it and he said it was not yet "FDA approved", and would not. I also found a compounding pharmacy that mixes Freeze-Dried Trimix.

According to that site, "Federal Court Affirms Your Right To Prescribe Custom Compounded Medications--August 30, 2006 (Midland Texas) -- In a much-anticipated landmark ruling, U.S. District Court Judge Robert Junell ruled that compounding custom prescriptions from bulk ingredients based on a prescription is legal and not under the jurisdiction of the Food and Drug Administration (FDA). The FDA had argued that compounded medications are 'new unapproved drugs' and that the agency should therefore have jurisdiction over compounding pharmacies".

I have used the self-injected Trimix ($95/5ml, using 0.20ml) with some slight success, except that it is hard for me to do it once I hit a vein and had bleeding out the tip of the penis. The Trimix-Gel seems a much better choice also as it doesn't lose potency with time/temperature like the regular compounded Trimix. It can be taken on a trip at room temperature and reconstituted using the two syringes when needed. Maybe I just need to get a new urologist!

I wonder what other members have had experience with either the Trimix-Gel or Freeze Dried Trimix, would you share your thoughts?
I am a new member to the site, looks like a lot of very useful straight info from guys that "have been there, done that".
Age-62, Gleason 3+3, PSA 1.60, Biopsy 9 of 12 positive. T2B, right lobe mostly.
Now three years post-Davinci Robotic Laparoscopic Radical Prostectomy (2-22-05),
with one sided nerve-sparing. PSA <0.1 consistently. Stress incontinence (1 pad/day).
Took Cialis 10 mg every other day for about a year, but no useable stiffs.

Tim G
Veteran Member

Date Joined Jul 2006
Total Posts : 2361
   Posted 10/7/2008 1:14 AM (GMT -6)   

The ingredients in TriMix gel are approved by the FDA for ED but the actual mix itself has not yet been approved.  Physicians can prescribe it and you can get it thru a compounding pharmacy. 

My urologist, who was voted one of the top urologists in the Seattle area by other physicians, keeps up with the newest available treatments for ED and had no hestitations about prescribing it for me.


Regular Member

Date Joined Mar 2007
Total Posts : 114
   Posted 10/8/2008 1:01 PM (GMT -6)   
Hi Tim - This sounds interesting and something I will bring up with my doc at my next appointment. I have random success with oral meds, bi-mix injections work but Im just not wild about the whole process. Would you mind explaining how this works, how it is applied, how long it lasts. etc? Thanks in advance
Diagnosed 1/26/07
Stage Tc1
Gleason 6
PSA 3.8
12 samples, positive in one 15%
Biopsy - 1% involvement, no bladder neck, Gleason 3+3, Tc1
Age 51
Surgery (robotic) May 4 2007 City of Hope
Final pathology - fully contained to prostate, TC1, Gleason 3+ 3
Fully continent one month
First Post op PSA - Undetectable
Second Post Op PSA (8/22/07)- Undetectable
ED- start injections 10/06/07
3rd Post op PSA 11/7 - Undetectable

Tim G
Veteran Member

Date Joined Jul 2006
Total Posts : 2361
   Posted 10/8/2008 9:54 PM (GMT -6)   
Pete-- The gel and powder--in two syringes--are mixed just before use. It is then squirted into the urethra, massaged a little and begins working in about 10 to 20 minutes. I'd say it's good for an hour or so.

If you want the detailed instructions in PDF format, e-mail me and I'll send them to you.


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