I have just completed 1-year of Triple Hormone Blockade in July 2008, under the direction of Dr. Steven Tucker (ex Compassionate Oncology) who now practices in Singapore. Although my bone density scan was borderline I did not have any medication to treat it, except an extra 200 mg of calcium/day in a multi-vitamin.
Side effects were a muzzy head, lack of energy, somewhat enlarged breasts, mood swings, ED, loss of libido. No hot flashes as far as I could tell.
During the course of the treatment my PSA reduced from 19.6 to 0.02. After stopping the hormone medication I expect the PSA to rise. The Leibowitz/Tucker study of 185 men with PCa showed the average PSA/Testosterone over 8-years in the following graph . . .
To Eknath, I found it very interesting you had another biopsy in May 2008 which showed no cancer. I hope this is another case of "disappearing prostate cancer" after hormone therapy. I don't intend to have another biopsy myself unluss absolutely necessary. My local doc also said I was "too young" for HT, but this didn't make sense to me since there is no evidence of the long term survival advantages of the standard RP/RT treatments.
All the best,
Diagnosed: June 2007. Aged 61. PSA 19.6. DRE negative.
Biopsy: June 2007; 2 cores of 18 positive.
MRI and Bone Scan: Negative.
Pathology: 5% of 1 core, "Small focus" in another core +ve.
Gleason 3 + 3 = 6.
Clinical: PCa considered confined to prostate. Stage T1c.
Treatment: After considering RP and HD Brachy, decided on Intermittent Triple Androgen Blockade Therapy for 1-year, using ZOLADEX, CASODEX 150 mg/day, AVODART 0.5 mg/day. Start PSA 19.2 (July 2007).
Completed Intermittent TAB on 23 July 2008, continue with AVODART alone and monitor PSA every 3-months.
Current Status: PSA = 0.02 (July 2008).
PSA nadir 0.018 (June 2008).