Zometa for bones

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Jack Z
Regular Member

Date Joined Jul 2008
Total Posts : 43
   Posted 9/10/2008 4:28 PM (GMT -7)   
I visited my oncologist tday for my first shot of Lupron and while I was there he suggested that I begin Zometa since the cancer is also in my hip.
I am wondering if anyone has had experience with this drug and its +'s and -'s Look like there are lots of side effects!
Any comments will be helpful.
Male: 63
PSA: 12.5
Biopsy 7-29-08 12 cores taken. 
Biopsy Result 8/19/08 Gleason 9 (4+5), 12 of 12 positive,
CT Scan: Positive Lymph Node Involvement
Bone Scan: Positive Involvement shows in right hip
Treatment: Hormone Therapy: Casodex started 8/28/08
First Lupron Shot Scheduled 9/10/08

Regular Member

Date Joined Apr 2008
Total Posts : 65
   Posted 9/10/2008 6:14 PM (GMT -7)   

Hi Jack,

My husband used Zometa for a few months, but had to stop because of other complications with his kidneys. His oncologist had also said that Zometa was important because of bone mets and I have a friend who is a rep for the Zometa company who also speaks highly of its benefits (maybe a little biased). My husband's first treatment made him feel like he had been hit by a mac truck for about a week. The next treatment he felt bad for just a few days. The doctor had said that each time you feel less side-effects. I have read that it helps the bone rejuvinate stronger and helps to slow the progression of any cancer spread to some degree. Sorry I can't give you any long term help.

Good luck and I hope you can get some more insight.

Karen eyes

Karen--New York
Husbands Info:
Age of diagnosis--62
2/28/08--PSA 279   DRE--positive/rock hard
Flomax and Casadex started
Biopsy--3/7/08--187cc--Gleason 10--12 of 12 positive--Perineural and LV invasion identified
T4 bone met.--hydroureteronephrosis/right kidney
3/28/08--Lupron Inj. started
4/7/08--Zometa IV started
5/15/08--PSA 12
5/20/08--Tubes placed in kidneys (through back)
5/21/08--diagnosed Neuro Endocrine Prostate carcinoma
5/28-30/08--1st round Chemo
6/18-20/08--2nd round Chemo
7/2/08--blood clot--Coumadin started
7/10/08--Stop chemo--cancer not responding
7/20-24--hospitalized for some type of seizure
7/24--New chemo given-no response
8/20/08--Start Hospice

FLHW(David E)
Regular Member

Date Joined Nov 2007
Total Posts : 201
   Posted 9/10/2008 7:54 PM (GMT -7)   
I've been on it for about two years.

No real side effects, however I have them administer over 25 minutes (standard is 15),
I did this because the first treatment left me in a lot of pain. I've had no issues since
Dx'd 2/18/05
PSA 271, bone mets, lymph node involvement
Gleason Score: 7
Current (9-2-08)
PSA: 41.36
Taxotere + Prednisone + Atrasentan
[5th Treatment on September 2]
Clinical Trial:
Personal Blog:

Regular Member

Date Joined Jul 2007
Total Posts : 57
   Posted 9/11/2008 8:36 AM (GMT -7)   
My husband has no detectable bone mets but Zometa was ordered every six months due to bone density issues after a year and a half of hormone therapy.  He had the first infusion a few weeks ago.  He said he felt some slight aches and pains a few days after but no real side effects.  The clinic did mention they give the first infusion at a slower rate which is said to help. 

New Member

Date Joined Sep 2008
Total Posts : 1
   Posted 9/14/2008 10:10 PM (GMT -7)   
My other half had his first Zometa IV the 25th of August. He had a severe allergic reaction to the medication which caused him to have every side effect with 10 times the aching, fever, hive type bumps, nausea, etc. I had to rush him to doctor so they could prescribe a pain medication. That didn't help. He had dry heaves for almost 24 hours. A second trip to doctor and he was administered 1000 units of Saline Solution and a nausea medication and prescribed a different pain medication. He is just now able to get around and eat a little better. They said this happens sometimes but rarely.

He will be 72 in a few weeks.
PSA was reading 17.0
bone mets in shoulder, ribs, and lower back -
Has been on Zolodex for about a year
Casodex for 2 months.
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