Stage 3 and 4 Guys! Study about adjuvant therapies!

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 9/15/2008 4:58 PM (GMT -7)   
I have been seeing some new faces, too many, over the last couple months that have been diagnosed with advanced disease (locally or metastatic).  A lot of positive margin guys.  I am sorry about your pathologies, I am one of you.  I am approaching my second year living with the "bad" pathology.  But I am doing well and will have a battery of tests this Wednesday followed by another Lupron shot.  I will post those results here as soon as I get them.  When I found out about my condition I decided to be very "online" about my disease.  Many of you veterans have probably heard my story way too much.  For 6 months I moderated this forum and I am now into prostate cancer advocacy groups.  There are many big time advocates at TNPCIL and I have learned quite a bit from them.  When you guys post something new or informational, I try to see if I can go to some sites by these folks and get detailed information to supplement your posts.  The most contraversial stage in prostate cancer is stage 3.  Stage 4 means HT, RT, and its pretty straight forward.  Stage 3 is almost the same except that many doctors don't explain what all the options are.  That surprises me.  Even if one treatment to another won't always have difinitive results, you should still be offered all of the options.  I was lucky, all of my staff stated their position, and in many cases, as expected, recommended their compitency.  But through the net I found that my odds were improved by using a combination of adjuvant therapies.  It wasn't a lot, but hey, if it was shown to help I was doing it.  I stopped at adjuvant Taxotere because of my fear of neuropathy.  I love being a musician and I didn't want to lose the fingers...OK, back on topic.  There are studies that show adjuvant versus salvage treatments are working better.
 
I am posting this blog from Mike Scott at The "New" Prostate Cancer InfoLink about adjuvant treatments of advanced stage guys.  Click Here to see it!
 
I have received some Email from a couple of you, so this might be redundant to you.  Hang in there I can really be redundant! tongue
 
Tony
Age 46 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Extra Prostatic Extension (EPE)
Bilateral seminal vesicle invasion (SVI); Stage pT3b, N0, Mx
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 9 '08): <0.1 ~ Undetectable!
 
You can visit my Journey at:
 
STAY POSITIVE!
 
 


livinadream
Veteran Member


Date Joined Apr 2008
Total Posts : 1382
   Posted 9/15/2008 5:25 PM (GMT -7)   
thanks Tony I am about to check this out.
I have always been confused myself as to exactly what defines stage 3 from stage 4?

peace to you
Dale
My PSA at diagnosis was 16.3
age 46 (current)
My gleason score from prostate was 4+5=9 and from the lymph nodes was 4+4=8
I had 44 IMRT's
Casodex
Currently on Lupron
I go to The Cancer Treatment Center of America
Married with two kids
latest PSA 5-27-08 0.11
PSA July 24th, 2008 is 0.04
cancer in 4 of 6 cores
92%
80%
37%
28%
 


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 9/15/2008 5:42 PM (GMT -7)   
There are two tables floating around, actually a third that was discontinued.  My disease is the last step to stage IV in the latest updated tables (pT3c no longer exists, but some doctors still use it) 
 
Here it is from Phoenix 5:
 
Stage I prostate cancer: Cancer that is only in the prostate gland, cannot be felt during a digital rectal examination, is not visible by imaging, and causes no symptoms. It is usually found accidentally or because a blood test showed an elevated prostate-specific antigen (PSA) level. Cancer cells may be found in only one area of the prostate or they may be found in many areas of the prostate. Similar to stage A in the Whitmore-Jewett staging system.

Stage II prostate cancer: Cancer that may be found by a
needle biopsy done because a blood test showed elevated prostate-specific antigen (PSA); or cancer which may be felt in the prostate gland during a digital rectal examination, even though the cancer cells are found only in the prostate gland. Similar to stage B in the Whitmore-Jewett staging system.

Stage III prostate cancer: Cancer cells have spread outside the covering (capsule) of the prostate gland to tissues around the prostate but not to the lymph nodes. The glands that produce semen (the seminal vesicles) may have cancer cells in them. Similar to stage C in the Whitmore-Jewett staging system.

Stage IV prostate cancer: Cancer cells have spread (metastasized) to lymph nodes (near or far from the prostate gland) or to organs and tissues far away from the prostate such as the bone, liver, or lungs. Similar to stage D in the Whitmore-Jewett staging system.
Age 46 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Extra Prostatic Extension (EPE)
Bilateral seminal vesicle invasion (SVI); Stage pT3b, N0, Mx
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 9 '08): <0.1 ~ Undetectable!
 
You can visit my Journey at:
 
STAY POSITIVE!
 
 


mvesr
Veteran Member


Date Joined Apr 2007
Total Posts : 823
   Posted 9/15/2008 6:00 PM (GMT -7)   
Hi Tony

Hope you are doing well. My wife and I attended Duke's Prostate Cancer seminar this past saturday. Among the topics including discussions that were over my head about stage 3 and 4 cancer, Mike Scott addressed the group. Besides being a very interesting British Guy, he has a lot of knowedge about our problem. His view on forums and websites were very interesting.

Take care

Mika
age at dx 54 now 56
psa at dx 4.3
got the bad news 1/29/07
open surgery Duke Medical Center 5-29-07
never more than 2 pads
Tossed the pads this spring
ED still a problem
first year PSA less than zero
 


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 9/15/2008 9:35 PM (GMT -7)   

He's a great guy, Mika,
He and Arnon Krongrad are doing a great thing together by starting TNPCIL.  I knew they were going to Duke with there "ambassador" Angela Jenkins to talk about the internet and their new web site.  I have presented this internet tool to US Too here in Vegas and will bring the material again to our local US Too group.  It's funny that he's a British citizen but he, with the help of others, was largely responsible for starting the biggest advocacy group in the US (NPCC ~ National Prostate Cancer Coalition).  Mike does not have prostate cancer, but he has a flare for the cause.  You can meet him at my TNPCIL web page in my signature.

By the way, under the leadership of Skip Lockwood, the NPCC has changed its name to Zero ~ The project to end prostate cancer...But continue to support these guys, and their HW unpostable petition...(Ask me about it).

Tony


Age 46 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Extra Prostatic Extension (EPE)
Bilateral seminal vesicle invasion (SVI); Stage pT3b, N0, Mx
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 9 '08): <0.1 ~ Undetectable!
 
You can visit my Journey at:
 
STAY POSITIVE!
 
 


livinadream
Veteran Member


Date Joined Apr 2008
Total Posts : 1382
   Posted 9/16/2008 3:19 AM (GMT -7)   
Thanks for the info Tony, and yes that clarified my question about staging. I was refered to as stage 4 by my doctor and that confirms it.
Email me sometime Angela Jenkins and I are talking about a cool new project and your name was brought up. Small country we live in, isn't it?

peace to you
Dale
My PSA at diagnosis was 16.3
age 46 (current)
My gleason score from prostate was 4+5=9 and from the lymph nodes was 4+4=8
I had 44 IMRT's
Casodex
Currently on Lupron
I go to The Cancer Treatment Center of America
Married with two kids
latest PSA 5-27-08 0.11
PSA July 24th, 2008 is 0.04
cancer in 4 of 6 cores
92%
80%
37%
28%
 


divo
Veteran Member


Date Joined Jul 2008
Total Posts : 637
   Posted 9/16/2008 5:17 PM (GMT -7)   
Thanks Tony...so much. You are doing God's work here on earth....Pete is stage 4 now , I guess....although, he just had the AUS implant and hopefully that will work...Life is what it is...You have to accept what is...and forge ahead........You certainly are, and you are helping others to do the same. You are special and you have found your niche .....D
Husband Pete
dx Jan 2001 age 67 gleason 4 + 3 PSA 16.5
seed implant and conformal radiation Lupron from Jan 2001 to Jan2002
2005 Dec PSA began to rise from .5 to 8 within 6 months
Salvage surgery at MSK 9/06
Fistula operation 2/07 MSK
Many cystoscopies and ER visits with strictures
catheter for one year....Catheter taken out Sept 07..
Total Incontinence since then....
PSA .52 3/07
AUS Operation at MSK Sept 8. Dr. Sandhu
Waiting for activation October 21 2008


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 9/16/2008 11:15 PM (GMT -7)   

Diane,

You are very sweet.  If surfing and finding friends and information and sharing it is anything good, I can do that.  I have enough experience with PCa to be able to answer questions, but why just keep it stored in my head?  And besides I frequently learn from just about anyone.  Especially about the courage and compassion shown so often here.  I feel I take away so much more from HealingWell than can I give. 

Dale,

Tell Angela I said "Hi" and that I'm awaiting her call...I'll call you this week to wish you luck this weekend at your "Champions of Hope Celebration" at your website! (And also mine!).

Peace

 

Tony



Age 46 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Extra Prostatic Extension (EPE)
Bilateral seminal vesicle invasion (SVI); Stage pT3b, N0, Mx
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (May 9 '08): <0.1 ~ Undetectable!
 
You can visit my Journey at:
 
STAY POSITIVE!
 
 


RBinCountry
Regular Member


Date Joined Apr 2008
Total Posts : 270
   Posted 9/17/2008 6:41 AM (GMT -7)   
Tony,
I have visited your site and frankly got a little teary-eyed. I simply want to thank you for sharing your life. It is obvious from your remarks that you know Romans 8:28. I would further suggest that the reason behind your condition is likely to be the blessing you have become. I am also sure that your situation has drawn you closer to the Almighty. Thank you again for what you do! Blessings.

RB

Age 61
Original data - pre-operation
PSA: 5.1
T1C clinical diagnosis, Needle biopsy - 10 cores, Gleason 7 = 3+4 in 1 core (40%), 7 cores Gleason 6 = 3+3 ranging from 5% to 12%
All scans negative
Lupron administered 4/9/2008 for 4 months (with idea I would undergo external beam radiation followed by seed implants - then I changed my mind).
Robotic DiVinci surgery - Dr. Fagin (Austin) May 19th
Post operative - pathology
pT2c NX MX
Gleason 3+4
Margins - negative
Extraprostatic extension - negative
seminal vesicle invasion - uninvolved
1st Post PSA .04

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 9/28/2008 12:43 PM (GMT -7)   
Thank you RB,
We are doing well here, and I love that passage. I do find hope in it.

I am bumping this thread for my brothers who have the later stages...

Tony
Age 46 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007 @ The City of Hope
Post-Op Pathology: Gleason 4+3=7, positive margins, Extra Prostatic Extension (EPE)
Bilateral seminal vesicle invasion (SVI); Stage pT3b, N0, Mx
HT began in May, '07 with Lupron and Casodex 50mg (2 Year ADT)
IMRT radiation for 38 Treatments ending August 3, '07
Current PSA (September 17 '08): <0.1 ~ Undetectable!
 
You can visit my Journey at:
 
STAY POSITIVE!
 
 

New Topic Post Reply Printable Version
Forum Information
Currently it is Wednesday, February 21, 2018 4:00 PM (GMT -7)
There are a total of 2,931,772 posts in 321,674 threads.
View Active Threads


Who's Online
This forum has 160382 registered members. Please welcome our newest member, Suzieq28.
434 Guest(s), 7 Registered Member(s) are currently online.  Details
SteveSR, 1 day at a time, Hoagie, Garion, Saipan Paradise, Labradorite, Robertmp